Juan L Paris,María Vallet-Regí
Juan L Paris
Ultrasound has attracted much attention in recent years as an external stimulus capable of activating different types of nanomaterials for therapeutic application. One of the characteristics that makes ultrasound an especially appealing tri...
Cyclic β2,3-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease [0.03%]
cyclic β2,3-氨基酸可提高针对SARS-CoV-2主要蛋白酶的环状肽抑制剂的血清稳定性
Takashi Miura,Tika R Malla,Lennart Brewitz et al.
Takashi Miura et al.
Due to their constrained conformations, cyclic β2,3-amino acids (cβAA) are key building blocks that can fold peptides into compact and rigid structures, improving peptidase resistance and binding affinity to target proteins, due to their ...
Asymmetric Synthesis of 1-Tetralones Bearing A Remote Quaternary Stereocenter through Rh-Catalyzed C-C Activation of Cyclopentanones [0.03%]
通过Rh催化环戊酮的C-C活化实现远端季碳手性中心四氢萘酮的不对称合成
Shusuke Ochi,Ying Xia,Guangbin Dong
Shusuke Ochi
Herein, we describe the preparation of 1-tetralones bearing a remote quaternary stereocenter in a highly enantioselective manner. A sequence of Pd-catalyzed asymmetric 1,4-addition and Rh-catalyzed enantiospecific C-C/C-H activation deliver...
Instructed-Assembly (iA): A Molecular Process for Controlling Cell Fate [0.03%]
指令组装(iA)：一种控制细胞命运的分子过程
Hongjian He,Bing Xu
Hongjian He
Instructed-assembly (iAssembly or iA) refers to the formation of ordered superstructures of molecules as the consequence of at least one trigger event (e.g., a reaction or a ligand-receptor interaction). As a biomimetic process that transfo...
A ICHIHARA,T YAMANAKA,T MATSUMOTO
A ICHIHARA
H MAEKAWA,A ICHIHARA,T MATSUMOTO
H MAEKAWA
K FUKUI,M NAKAYAMA,A TANAKA et al.
K FUKUI et al.
MONOLAYER STUDIES OF THE INTERACTIONS BETWEEN HISTIDYL POLYPEPTIDES AND METAL IONS. II. THE EFFECTS OF COPPER, ZINC, COBALT AND CALCIUM IONS ON THE MONOLAYER PROPERTIES OF POLY-1-BENZLY-L-HISTIDINE [0.03%]
组氨酸多肽与金属离子相互作用的单分子膜研究．Ⅱ．Cu2+，Zn2+，Co2+和Ca2+对聚一苄基-l-组氨酸单层性质的影响
T YAMASHITA,T ISEMURA
T YAMASHITA