Digital design of an integrated purification system for continuous pharmaceutical manufacturing [0.03%]
连续药物制造集成净化系统的数字设计
Inyoung Hur,Daniel Casas-Orozco,Daniel Laky et al.
Inyoung Hur et al.
In this work dynamic models of the continuous crystallization, filtration, deliquoring, washing, and drying steps are introduced, which are developed in the open-source pharmaceutical modeling tool PharmaPy. These models enable the simulati...
Mathematical modeling and digital design of an intensified filtration-washing-drying unit for pharmaceutical continuous manufacturing [0.03%]
制药连续生产中强化过滤-洗涤-干燥单元的数学建模及数字设计
Francesco Destro,Inyoung Hur,Vivian Wang et al.
Francesco Destro et al.
This paper introduces a comprehensive mathematical model of a novel integrated filter-dryer carousel system, designed for continuously filtering, washing and drying a slurry stream into a crystals cake. The digital twin includes models for ...
Reaction kinetics determination and uncertainty analysis for the synthesis of the cancer drug lomustine [0.03%]
癌症药物洛莫司汀合成反应的动力学确定及不确定度分析
Daniel Casas-Orozco,Daniel Laky,Jaron Mackey et al.
Daniel Casas-Orozco et al.
Fast and reliable model development frameworks are required to support current trends in modernization of pharmaceutical processing, promoting the use of digital platforms to assist process design and operation. In this work, we use a param...
Machine Learning Methods for Endocrine Disrupting Potential Identification Based on Single-Cell Data [0.03%]
基于单细胞数据的内分泌干扰物潜在影响识别的机器学习方法
Zahir Aghayev,Adam T Szafran,Anh Tran et al.
Zahir Aghayev et al.
Humans are continuously exposed to a variety of toxicants and chemicals which is exacerbated during and after environmental catastrophes such as floods, earthquakes, and hurricanes. The hazardous chemical mixtures generated during these eve...
Stewart Russell,Limary M Cancel,John M Tarbell et al.
Stewart Russell et al.
Water transport across the arterial endothelium is believed primarily to occur through breaks in the tight junction strands at the cell periphery between neighboring cells. Additional proteins arriving at the tight junction can close these ...
Synthesis of a novel anti-fog and high-transparent coating with high wear resistance inspired by dry rice fields [0.03%]
受干稻田启发合成一种新型高透明、抗雾化且耐磨损的涂层
Juan Xiang,Xiaoying Liu,Yan Liu et al.
Juan Xiang et al.
During the outbreak of COVID-19, the fogging of goggles was a fatal problem for doctors. At present, there are many ways to prevent fogging by adjusting surface wettability. However, the mechanical properties of most super-hydrophilic antif...
Synthetic biology strategies for synthesizing polyhydroxyalkanoates from unrelated carbon sources [0.03%]
利用合成生物学策略由不同碳源合成聚羟基脂肪酸酯类聚合物
Daniel E Agnew,Brian F Pfleger
Daniel E Agnew
Discovered in the 1920's, polyhydroxyalkanoates (PHA) are a naturally occurring class of biopolyesters that have long been touted as a renewable, biodegradable plastic alternative. Demand for sustainable products and over a half century of ...
Optimization of loop-mediated isothermal amplification (LAMP) assay for robust visualization in SARS-CoV-2 and emerging variants diagnosis [0.03%]
用于可视化SARS-CoV-2及其新出现的变异株的环介导等温扩增（LAMP）检测优化方法
Zhen Luo,Chunhong Ye,Heng Xiao et al.
Zhen Luo et al.
Loop-mediated isothermal amplification (LAMP) is widely used in detection of pathogenic microorganisms including SARS-CoV-2. However, the performance of LAMP assay needs further exploration in the emerging SARS-CoV-2 variants test. Here, we...
Harisankar Ramaswamy,Assad A Oberai,Yannis C Yortsos
Harisankar Ramaswamy
Motivated by analogies between the spread of infections and of chemical processes, we develop a model that accounts for infection and transport where infected populations correspond to chemical species. Areal densities emerge as the key var...
COVID-19: Mechanistic model calibration subject to active and varying non-pharmaceutical interventions [0.03%]
冠状病毒病(COVID-19):结合主动和动态的非药物干预进行机制模型校准
Mark J Willis,Allen Wright,Victoria Bramfitt et al.
Mark J Willis et al.
Mathematical models are useful in epidemiology to understand COVID-19 contagion dynamics. We aim to demonstrate the effectiveness of parameter regression methods to calibrate an established epidemiological model describing infection rates s...