Synthesis of 2-arylpyridines by the Suzuki-Miyaura cross-coupling of PyFluor with hetero(aryl) boronic acids and esters [0.03%]
吡咯并氟化物与杂芳基硼酸和酯的suzukimiyaura交叉偶联反应合成2-芳基哒嗪类化合物
Juan Rueda-Espinosa,Dewni Ramanayake,Nicholas D Ball et al.
Juan Rueda-Espinosa et al.
The Suzuki-Miyaura cross-coupling of pyridine-2-sulfonyl fluoride (PyFluor) with hetero(aryl) boronic acids and pinacol boronic esters is reported. The reactions can be performed using Pd(dppf)Cl2 as the catalyst, at temperatures between 65...
Comparison of sample preparation methods for rare cell isolation in microfluidic devices [0.03%]
微流控器件中稀有细胞分离的样品制备方法的比较研究
Jose I Varillas,Kangfu Chen,Pablo Dopico et al.
Jose I Varillas et al.
The analysis of circulating tumor cells (CTCs) is important for cancer diagnosis and prognosis. Microfluidics has been employed for CTC analysis due to its scaling advantages and high performance. However, pre-analytical methods for CTC sam...
Ligand Substitution and Electronic Structure Studies of Bis(phosphine)Cobalt Cyclooctadiene Precatalysts for Alkene Hydrogenation [0.03%]
联芳基膦钴环辛烯配合物的配体交换和氢化烯烃性质研究
Hongyu Zhong,Megan Mohadjer Beromi,Paul J Chirik
Hongyu Zhong
Diene self-exchange reactions of the 17-electron, formally cobalt(0) cyclooctadienyl precatalyst, (R,R)-(iPrDuPhos)Co(COD) (P 2 CoCOD, (R,R)-iPrDuPhos = 1,2-bis((2R,5R)-2,5-diisopropylphospholano)benzene, COD = 1,5-cyclooctadiene) were stud...
The Bioactive Lipid (S)-Sebastenoic Acid Impacts Motility and Dispersion in Vibrio cholerae [0.03%]
生物活性脂质（S）-Sebastenoic酸对霍乱弧菌运动性和分散性的影响
Christopher J A Warner,Mauro Salinas,David Zamorano-Sánchez et al.
Christopher J A Warner et al.
Although Gram-negative bacterial pathogens continue to impart a substantial burden on global healthcare systems, much remains to be understood about aspects of basic physiology in these organisms. In recent years, cyclic-diguanylate (c-di-G...
Michael G Lancina rd,Hu Yang
Michael G Lancina rd
Existing methods of administering ocular drugs are limited in either their safety or efficiency. Nanomedicine therapies have the potential to address this deficiency by creating vehicles that can control drug biodistribution. Dendrimers are...
Modeling nuclear resonance vibrational spectroscopic data of binuclear non-heme iron enzymes using density functional theory [0.03%]
用密度泛函理论模拟双核非血红素铁酶的核共振振动光谱数据
Kiyoung Park,Edward I Solomon
Kiyoung Park
Nuclear resonance vibrational spectroscopy (NRVS) is a powerful technique that can provide geometric structural information on key reaction intermediates of Fe-containing systems when utilized in combination with density functional theory (...
Structural features of the carbon-sulfur chemical bond: a semi-experimental perspective [0.03%]
碳硫化学键的结构特征：一种半实验视角
Emanuele Penocchio,Marco Mendolicchio,Nicola Tasinato et al.
Emanuele Penocchio et al.
In this work semi-experimental and theoretical equilibrium geometries of 10 sulfur-containing organic molecules, as well as 4 oxygenated ones, are determined by means of a computational protocol based on density functional theory. The resul...
Extension and validation of the GLYCAM force field parameters for modeling glycosaminoglycans [0.03%]
糖胺聚糖建模的GLYCAM力场参数的扩展与验证
Arunima Singh,Matthew B Tessier,Kari Pederson et al.
Arunima Singh et al.
Glycosaminoglycans (GAGs) are an important class of carbohydrates that serve critical roles in blood clotting, tissue repair, cell migration and adhesion, and lubrication. The variable sulfation pattern and iduronate ring conformations in G...
Unnatural C-1 homologues of pancratistatin - Synthesis and promising biological activities [0.03%]
Pancratistatin的C-1 unnatural同系物的合成及其令人振奋的生物活性
Sergey Vshyvenko,Jon Scattolon,Tomas Hudlicky et al.
Sergey Vshyvenko et al.
Several C-1 homologues of pancratistatin and 7-deoxypancratistatin were synthesized by a phenanthrene-phenathridone oxidative recyclization strategy. The key steps involved the enzymatic dihydroxylation of bromobenzene, addition of an aryl ...
Formation of Hg(II) Tetrathiolate Complexes with Cysteine at Neutral pH [0.03%]
半胱氨酸在中性PH条件下形成Hg(II)四硫醇复合物
Thomas Warner,Farideh Jalilehvand
Thomas Warner
Mercury(II) ions precipitate from aqueous cysteine (H2Cys) solutions containing H2Cys/Hg(II) mole ratio ≥ 2.0 as Hg(S-HCys)2. In absence of additional cysteine, the precipitate dissolves at pH ~12 with the [Hg(S,N-Cys)2]2- complex dominati...