SARS-COV-2 Coronavirus Papain-like Protease PLpro as an Antiviral Target for Inhibitors of Active Site and Protein-Protein Interactions [0.03%]
靶向SARS-CoV-2冠状病毒半胱氨酸蛋白酶样蛋白酶PLpro活性位点及蛋白质相互作用的小分子抑制剂抗病毒研究
P V Ershov,E O Yablokov,Y V Mezentsev et al.
P V Ershov et al.
The papain-like protease PLpro of the SARS-CoV-2 coronavirus is a multifunctional enzyme that catalyzes the proteolytic processing of two viral polyproteins, pp1a and pp1ab. PLpro also cleaves peptide bonds between host cell proteins and ub...
Development of Medical Sensor Systems in Pulmonology Based on Electrical Impedance Measurement [0.03%]
基于电阻抗测量的肺科医疗传感器系统的发展
V Ju Mishlanov,A L Zuev,Ya V Mishlanov
V Ju Mishlanov
In order to experimentally confirm the dependence of the bioelectrical impedance on the flow rate of charged aerosol particles and the composition of bronchial secretions in small airways, the electrical impedance of an aerosol of 0.9% NaCl...
High Dose Inhalation with Gaseous Nitric Oxide in COVID-19 Treatment [0.03%]
高剂量吸入一氧化氮在治疗COVID-19中的应用
E V Pechyonkin,A V Kovrizhkin,A V Pekshev et al.
E V Pechyonkin et al.
A method of treatment of a new coronavirus infection COVID-19 in patients undergoing high flow oxygenation is proposed and technically implemented; the method is based on high-dose inhalation of gaseous nitric oxide (NO) with the patient's ...
Causal Relationship between Physiological and Pathological Processes in the Brain and in the Gastrointestinal Tract: The Brain-Intestine Axis [0.03%]
中枢和肠道病理生理过程之间的因果关系：脑肠轴
V P Reutov,E G Sorokina
V P Reutov
The brain and gastrointestinal tract are the most important organs responsible for detecting, transmitting, integrating, and responding to signals coming from the internal and external environment. A bidirectional system of neurohumoral com...
Tissue-Engineered Constructions in Biophysics, Neurology and Other Fields and Branches of Medicine [0.03%]
生物物理学，神经学和其他医学领域和分支中的组织工程构建体
V P Reutov,L A Davydova,E G Sorokina
V P Reutov
This paper describes the gangliopexy method, a method for creating a new center of local neurohumoral regulation, based on the formation of new connections discovered between the nervous system and the vascular system. The prospects for the...
The Cytostatic Action of Dinitrosyl Iron Complexes with Glutathione on Escherichia coli Cells Is Mediated by Nitrosonium Cations Released from These Complexes [0.03%]
谷胱甘肽二硝酰铁络合物对大肠杆菌细胞的细胞静止作用是由这些络合物释放的亚硝基阳离子介导的
A F Vanin,V I Telegina,V D Mikoyan et al.
A F Vanin et al.
This study demonstrates a bacteriostatic effect of binuclear dinitrosyl iron complexes with glutathione on Escherichia coli TN300 cells. It has been quantified by the colony formation assay. The bacteriostatic effect exerted by these comple...
Antiviral Activity of Nitrosonium Cations against SARS-CoV-2 on a Syrian Hamster Model [0.03%]
硝基阳离子对叙利亚金仓鼠模型中SARS-CoV-2的抗病毒作用
A V Shipovalov,A F Vanin,O V Pyankov et al.
A V Shipovalov et al.
The antiviral action of binuclear dinitrosyl iron complexes with glutathione along with diethyldithiocarbamate against the SARS-CoV-2 virus has been demonstrated on a Syrian hamster model after aerosol exposure of SARS-CoV-2-infected animal...
T M Huseynov,R T Guliyeva,S H Jafarova et al.
T M Huseynov et al.
The review considers the role that selenium plays in RNA virus infections and, in particular, COVID-19. Many RNA viruses are selenium dependent because antisense interactions arise between viral RNAs and host mRNA regions containing the sel...
Skin Microhemodynamics and Mechanisms of Its Regulation in Type 2 Diabetes Mellitus [0.03%]
2型糖尿病皮肤微循环及调节机制研究
I V Tikhonova,A A Grinevich,A V Tankanag et al.
I V Tikhonova et al.
The review presents modern ideas about peripheral microhemodynamics, approaches to the ana-lysis of skin blood flow oscillations and their diagnostic significance. Disorders of skin microhemodynamics in type 2 diabetes mellitus (DM) and the...
A L Eryomin
A L Eryomin
The first work on noogenesis as evolution of intellect was published 150 years ago. However, it was not until the 21st century that quantitation became possible for certain parameters that contribute to the understanding of the evolution of...