Antimicrobial therapy and outcome of septicemia patients admitted to a University Hospital in Delhi [0.03%]
德里一家大学医院收治的败血症患者的抗微生物疗法及转归情况
M S Alam,P K Pillai,P Kapur et al.
M S Alam et al.
Septicemia is a common clinical condition encountered in most of the hospitals in this region of the world. However, limited information is available in the Indian literature on antimicrobial usage in patients with suspected or proven cases...
H M Aly,M G El-Gazzar
H M Aly
The present article describes the synthesis of some novel pyrrole, pyrazolo[4,3-d]oxazole, pyrrolo[2,3-b]pyridine, 1,2,3-triazole and oxoazetidin derivatives incorporating pyrazole moiety, the structures of which were confirmed by elemental...
Development of a sensitive bioanalytical method for the quantification of lacosamide in rat plasma. Application to preclinical pharmacokinetics studies in rats [0.03%]
大鼠血浆中拉考沙胺定量的敏感生物分析方法的发展及在大鼠药代动力学研究中的应用
S Shah,S G Vasantharaju,K Arumugam et al.
S Shah et al.
A sensitive and selective high performance liquid chromatographic (HPLC) method was developed and validated for quantification of lacosamide in rat plasma. A liquid-liquid extraction procedure was optimized to extract lacosamide from rat pl...
Pharmacokinetic and bioequivalence studies of trospium chloride after a single-dose administration in healthy Chinese volunteers [0.03%]
氯特罗튬在中国健康志愿者中的药代动力学和生物等效性研究
R Zhang,G Yuan,R Li et al.
R Zhang et al.
The study aimed to compare and evaluate the bioequivalence of a new generic preparation of trospium chloride (CAS NO:10405-02-4) capsule (20 mg, test) and the available import tablet (20 mg , reference) for the requirement of state regulato...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 May;62(5):247-51. DOI:10.1055/s-0032-1304649 2012
Novel LC-MS/MS method for simultaneous quantification of KW-7158, a new drug candidate for urinary incontinence and bladder hyperactivity, and its metabolites in rat plasma: a pharmacokinetic study in male and female rats [0.03%]
一种新的用于治疗尿失禁和膀胱过度活动症的候选药物KW-7158及其代谢产物在大鼠血浆中同时定量的新LC-MS/MS方法：雄性和雌性大鼠中的药动学研究
H Maeda,K Fujita,H Kobayashi et al.
H Maeda et al.
To investigate the pharmacokinetics of KW-7158 (CAS 214763-95-8), a new drug candidate for urinary incontinence and bladder hyperactivity, in male and female rats, we developed and validated a simultaneous quantification method for KW-7158 ...
Quantification of azithromycin in human plasma by liquid chromatography tandem mass spectrometry: application to a bioequivalence study [0.03%]
液相色谱-串联质谱法测定人血浆中阿奇霉素的含量及其在生物等效性研究中的应用
B Jiang,J Chen,Z Ruan et al.
B Jiang et al.
A specific, sensitive and rapid liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method has been developed and validated for the determination of azithromycin in human plasma. After deproteinizing the pl...
The multidrug resistant modulator HZ08 reverses multidrug resistance via P-glycoprotein inhibition and apoptosis sensitization in human epidermoid carcinoma cell line KBV200 [0.03%]
多药抗性调节剂HZ08通过P-糖蛋白抑制和促凋亡作用逆转人表皮鳞状细胞癌耐药亚系KBV200的多重耐药性
Y-L Zhu,J Cen,Y-Y Zhang et al.
Y-L Zhu et al.
Previous studies have demonstrated that the multidrug resistance modulator HZ08 has a strong multidrug resistance reversal effect in vitro and in vivo by inhibiting P-glycoprotein and multidrug resistance-associated protein 1 in K562/A02 an...
Quantitative determination of pidotimod in human plasma by liquid chromatography tandem mass spectrometry: application to a bioequivalence study [0.03%]
高效液相色谱-质谱联用测定人血浆中匹多莫德的含量及其生物等效性研究
H-G Lou,Z-R Ruan,B Jiang
H-G Lou
A highly sensitive and simple LC-MS/MS method after one-step protein precipitation was developed and validated for determination of pidotimod (CAS 121808-62-6) in human plasma using dextrophan (CAS 125-73-5) as internal standard (IS). Pidot...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Feb;62(2):99-104. DOI:10.1055/s-0031-1297983 2012
C de Mey,V Dimitrova,P Lennartz et al.
C de Mey et al.
To investigate whether rapidly dissolving levetiracetam minitablets are bioequivalent to a single tablet of the same strength. 2 bioequivalence studies were carried out investigating the 1 000 mg and 1 500 mg strength of such novel medicina...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Feb;62(2):94-8. DOI:10.1055/s-0031-1297965 2012