Formulation and comparative bioavailability of 2 ciprofloxacin sustained release tablets [0.03%]
两规格环丙沙星缓释片的处方工艺及生物等效性研究
A N Zaid,A Qaddomi,S Khammash
A N Zaid
The aim of this study is to formulate and evaluate the quality of ciprofloxacin (CAS number: 85721-33-1) sustained release tablet (Ciprocare®XR) 1 000 mg ciprofloxacin (test formulation) by comparing its pharmacokinetic parameters with Cip...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Jul;62(7):319-23. DOI:10.1055/s-0032-1311609 2012
Intersex effect of lamotrigine on the pharmacokinetic parameters of CDRI-97/78, a novel trioxane antimalarial compound, in rats [0.03%]
拉莫三嗪对大鼠CDRI-97/78新型三氧烷类抗疟药物药动学参数的性别依赖性影响
H N Kushwaha,N Gautam,A Misra et al.
H N Kushwaha et al.
Reports regarding drug toxicity and adverse events resulting from coadministration of multiple drugs are increasing at an alarming rate. CDRI-97/78 is an 1,2,4-trioxane antimalarial agent under development which gets metabolized to the in v...
Pharmacokinetic equivalence of Taxotere and SID530, a novel docetaxel formulation containing hydroxypropyl-beta-cyclodextrin in monkeys [0.03%]
一种含有羟丙基-β-环糊精的多西他赛新制剂(SID530)与泰索帝在猴体内的药代动力学等同性研究
T K Kim,H H Yoo,E J Kim et al.
T K Kim et al.
SID530 is a new parenteral formulation of docetaxel containing hydroxypropyl-beta-cyclodextrin (HP-β-CD). In this study, a comparative pharmacokinetic study of 2 docetaxel parenteral solutions, SID530 and Taxotere, was carried out. In a cr...
Molecular combination of the dopamine and serotonin scaffolds yield in novel antipsychotic drug candidates - characterization by in vivo experiments [0.03%]
多巴胺和五羟色胺支架的分子组合产生新型抗精神病药物候选者-通过体内实验表征
M Schulze,O Siol,D Robaa et al.
M Schulze et al.
Serotonin and dopamine play an important role in the aetiology of schizophrenia. Combination of the structural scaffolds of both neurotransmitters in a single molecule lead to aromatic [d,g]-bisannelated azecine derivatives, which have been...
Determination of norcantharidin in mouse tissues by liquid chromatography coupled to tandem mass spectrometry and its tissue distribution study [0.03%]
液相色谱-串联质谱法测定蟾毒灵及其组织分布研究
R Zhang,J Wang,G Yuan et al.
R Zhang et al.
The purpose of this study is to determine the concentrations of norcantharidin (CAS NO: 5442-12-6) in mouse tissues and investigate its tissue distribution after intragastric administration of disodium norcantharidate solution. A highly sen...
Synthesis and anticonvulsant activity of some 2/3-benzoylaminopropionanilide derivatives [0.03%]
茋衍生物的合成及其抗惊厥活性研究
S Uysal,U Calis,Z Soyer
S Uysal
In this study, the synthesis and anticonvulsant properties of sixteen 2/3-benzoylaminopropionanilide derivatives were described. Molecular design of the compounds has been based on the modification of lacosamide which is a functionalized am...
Phase IV study comparing diurnal glycemic profile following the administration of 2 NPH plus regular human DNA recombinant insulin regimens in type 1 diabetes mellitus (T1DM) adult patients [0.03%]
一项在1型糖尿病成人患者中比较两次注射重组人DNA正规胰岛素(NPH)+正规人胰岛素与两次注射正规人胰岛素(NPH)+正规人胰岛素的Ⅳ期研究：对日间血糖谱的影响
E C Feleder,G A Yerino,E K Halabe et al.
E C Feleder et al.
Intensive insulin therapy (IIT) based on multiple daily injections of long plus rapid-acting insulin has been demonstrated to reduce mortality and morbidity associated with chronic hyperglycemia in T1DM patients. The objective of this study...
Clinical Trial
Arzneimittel-Forschung. 2012 Jun;62(6):267-73. DOI:10.1055/s-0032-1306274 2012
Physiological, pathophysiological and therapeutic impact of the enteric serotonergic system [0.03%]
肠血清素能系统的生理、病理生理和治疗作用
G J Molderings
G J Molderings
Serotonin (5-hydroxytryptamine, 5-HT) induces various effects in the central nervous system, cardiovascular system and gastrointestinal tract. The response depends primarily on the nature of the 5-HT receptors involved. In the light of the ...
Novel brain targeting prodrugs of naproxen based on dimethylamino group with various linkages [0.03%]
基于二甲氨基的各种连接的新型脑靶向萘普生前药
Q Zhang,Z Liang,L Y Chen et al.
Q Zhang et al.
As a preventive and treatment drug for Alzheimer's disease (AD), naproxen's clinical application is hampered by its limited distribution in the brain. To increase the delivery of naproxen across the blood-brain barrier (BBB), 3 prodrugs (P1...
Relative bioavailability of two 5-mg montelukast sodium chewable tablets: a single dose, randomized, open-label, 2-period crossover comparison in healthy korean adult male volunteers [0.03%]
两种5毫克孟鲁司特钠咀嚼片相对生物利用度的比较：一项针对健康成年男性志愿者的单剂量、随机开放标签、两周期交叉对比试验
H T Kim,Y-K Song,S D Lee et al.
H T Kim et al.
Montelukast sodium, cysteinyl leukotriene receptor 1 specific antagonist, has been marketed in Korea for the treatment of bronchial asthma and allergic rhinitis. The aim of this study was to compare the pharmacokinetics and relative bioavai...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Mar;62(3):123-7. DOI:10.1055/s-0031-1298004 2012