Comparative in vitro dissolution and in vivo bioequivalence of 2 pentoxifylline sustained release formulations [0.03%]
两种平消福林缓释制剂的体外溶出比较及体内生物等效性研究
P Zakeri-Milani,S Ghanbarzadeh,H Valizadeh
P Zakeri-Milani
Pentoxifylline is a xanthine derivative that is indicated for the treatment of patients with intermittent claudication on the basis of chronic occlusive arterial disease of the limbs. In the present study, prior to the in vivo study, an in ...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Jul;62(7):335-9. DOI:10.1055/s-0032-1312600 2012
Synthesis and Biological Activities of Some 1,3-Benzoxazol-2(3H)-One Derivatives as Anti-Quorum Sensing Agents [0.03%]
一类1,3-苯并恶唑-2(3h)-酮衍生物的合成及其抑菌作用
A M Miandji,S Ulusoy,Y Dündar et al.
A M Miandji et al.
The novel phenylpropiophenone derivates induced relaxation of isolated rat aorta [0.03%]
新型茋类衍生物苯丙苯酮对大鼠主动脉环的舒张作用
B Ivković,S Vladimirov,R Novaković et al.
B Ivković et al.
Our aim was to define how different chemical properties of newly developed phenylpropiophenone derivates (PhPds) influenced their potency and efficacy to relax rat aorta. A contribution of ion channels in the PhPds and propafenone mechanism...
S Almeida,P Pedroso,A Filipe et al.
S Almeida et al.
Escitalopram, CAS registry number 128196-01-0 is an orally administrated selective serotonin reuptake inhibitor (SSRI).The objective of this trial was to assess bioequivalence between an escitalopram formulation manufactured by Grupo Tecnim...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Jul;62(7):307-12. DOI:10.1055/s-0032-1309042 2012
Effect of triptolide on progesterone production from cultured rat granulosa cells [0.03%]
三粒脂对培养大鼠颗粒细胞孕酮生成的影响
J Zhang,Z Jiang,X Mu et al.
J Zhang et al.
Triptolide(CAS 38748-32-2), a major active component of Tripterygium wilfordii Hook F (TWHF), is known to have multiple pharmacological activities. However, studies have also shown that triptolide is highly disrupt to the reproductive syste...
Synthesis and biological activities of some 1,3-benzoxazol-2(3H)-one derivatives as anti-quorum sensing agents [0.03%]
一类1,3-苯并恶唑-2(3H)-酮衍生物的合成及其抗群体感应活性研究
A M Miandji,S Ulusoy,Y Dündar et al.
A M Miandji et al.
Antibiotics are commonly used to treat microbial infections. Due to misuse or large-scale use of antibiotics, many pathogens have gained resistance which makes antibiotic treatments ineffective. The discovery that many bacteria use quorum s...
In vitro and in vivo evaluation of Triptolide-loaded pluronic P105 polymeric micelles [0.03%]
三氧化二砷载药Pluronic P105聚meric胶束的体内外评价研究
H Li,X-S Wen,W Di
H Li
Thin film method was applied successfully to prepare Triptolide (TP)-loaded micelles system. With a dynamic light scattering sizer and a transmission electron microscopy, it was shown that the TP-loaded micelles had a mean size of 84.3±6.4...
Anti-nociceptive and anti-inflammatory effects of cyanocobalamin (vitamin B12) against acute and chronic pain and inflammation in mice [0.03%]
氰钴胺素(B12维生素)对小鼠急性及慢性疼痛和炎症的镇痛和抗炎作用
H Hosseinzadeh,S A Moallem,M Moshiri et al.
H Hosseinzadeh et al.
In this study, the anti-nociceptive and anti-inflammatory effects of cyanocobalamin (Vit B12) against acute and chronic pain and inflammation were evaluated in mice. Vit B12 (0.87, 1 and 1.77 mg/kg) were injected intraperitoneally. The anti...
Randomized double-blind study: wound-healing effects of a Symphytum herb extract cream (Symphytum×uplandicum Nyman) in children [0.03%]
随机双盲研究：Symphytum草药提取物软膏（Symphytum×uplandicum Nyman）对儿童伤口愈合的影响
M Barna,A Kucera,M Hladíkova et al.
M Barna et al.
The wound healing effects of the topically applied preparation Traumaplant® containing a concentrate (10% active ingredient) from the aerial parts of medicinal comfrey (Symphytum × uplandicum Nyman) were examined in a randomized, controll...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Jun;62(6):285-9. DOI:10.1055/s-0032-1308981 2012
Pharmacokinetics and cardiovascular effect of etoricoxib in the absence or presence of St. John's Wort in rats [0.03%]
番木鳖苷单成分和圣约翰草复方制剂在大鼠体内的药动学及心血管效应研究
M A Radwan,N A A Baky,I Zaghloul et al.
M A Radwan et al.
The effect of chronic administration of etoricoxib (EXB), in the absence or presence of St. John's Wort (SJW), on its pharmacokinetic parameters and blood pressure was investigated in rats.Rats were divided into 3 groups, each group receive...