Metronidazole immediate release formulations: a fasting randomized open-label crossover bioequivalence study in healthy volunteers [0.03%]
甲硝唑普通制剂的生物等效性研究是一项健康志愿者中的随机、空腹、开放标签交叉实验
M de Freitas Silva,S G Schramm,E K Kano et al.
M de Freitas Silva et al.
Metronidazole is a BCS (Biopharmaceutics Classification System) class 1 drug, traditionally considered the choice drug in the infections treatment caused by protozoa and anaerobic microorganisms. This study aimed to evaluate bioequivalence ...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Oct;62(10):490-5. DOI:10.1055/s-0032-1321873 2012
Bioequivalence study of 2 orodispersible formulations of zolmitriptan 5 mg in healthy volunteers [0.03%]
佐米曲普坦口溶片5mg两种剂型的人体生物等效性研究
M Cánovas,M Canals,F Polonio et al.
M Cánovas et al.
A bioequivalence study of 2 zolmitriptan (CAS 139264-17-8) orodispersible tablet formulations was carried out in 26 healthy volunteers according to an open label, randomized, 2-period, 2-sequence, crossover, single dose and fasting conditio...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Oct;62(10):482-6. DOI:10.1055/s-0032-1321848 2012
M S Iqbal,A H Khan,M Saeed et al.
M S Iqbal et al.
The study was aimed at determination of pharmacokinetic parameters of a previously synthesized salicylidine-sulfamethoxazole-Zn(II) monohydrate in normal humans. This new derivative of sulfamethoxazole was reported to be more active and les...
Vasodilation and hypotension of CZ454, an analogue of lacidipine through inhibiting extracellular calcium influx [0.03%]
新型二氢吡啶类钙拮抗剂CZ454的扩血管及降压作用与抑制细胞外钙内流有关
L-X Zhang,S-Q Zhang,Y-X Cao
L-X Zhang
The aim of this study was to evaluate the effects of an analogue of lacidipine, CZ454 in in vitro and in vivo. The isometric tension of Sprague-Dawley rat arterial ring segments was recorded by a myography system. Intracellular calcium of v...
Paracetamol (acetaminophen) - a popular and widely used nonopioid analgesic [0.03%]
对乙酰氨基酚（扑热息痛）：一种流行的非阿片类镇痛药
U Klotz
U Klotz
For several decades paracetamol has proven its clinical efficacy and safety in the treatment of various acute and chronic pain states. Whereas its pharmacokinetic properties (high oral bioavailability, good penetration into the brain, relat...
Design and synthesis of novel 3-(4-chlorophenyl)-2-(3-substituted propyl thio) quinazolin-4-(3H)-ones as a new class of H1-antihistaminic agents [0.03%]
一类新型的3-(4-氯苯基)-2-(3-取代丙基硫)-喹唑啉-4-(3H)-酮类H₁抗组胺剂的设计和合成研究
V Alagarsamy,P Parthiban
V Alagarsamy
A series of novel 3-(4-chlorophenyl)-2-(3-substituted propyl) quinazolin-4-(3H)-ones have been synthesized and tested for their in vivo H1-antihistaminic activity on conscious guinea pigs. All the test compounds have protected the animals f...
Liquid chromatography - tandem mass spectrometry for the simultaneous quantitation of glipizide, cilostazol and its active metabolite 3, 4-dehydro-cilostazol in rat plasma: application for a pharmacokinetic study [0.03%]
用于同时定量测定大鼠血浆中格列吡嗪、西洛他唑及其活性代谢物3,4-去氢-西洛他唑的液相色谱-串联质谱法及药代动力学研究应用
T R S Satheeshmanikandan,V Sridhar,V V S Kanthikiran et al.
T R S Satheeshmanikandan et al.
A liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) method for the simultaneous quantitation of glipizide, cilostazol and 3, 4-dehydro-cilostazol in rat plasma was developed and validated. Glimepride wa...
Comparative pharmacokinetics and bioequivalence of two 50 mg atenolol tablet formulations in healthy Korean male volunteers [0.03%]
两种阿替洛尔片剂在健康韩国男性受试者中的药代动力学和生物等效性比较研究
M J Chang,W G Shin
M J Chang
Atenolol is a selective β1 receptor antagonist that is available as a racemic mixture. The objective of this study was to compare the pharmacokinetics and evaluate the bioequivalence of 50 mg atenolol test and reference formulations in 24 ...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Sep;62(9):410-3. DOI:10.1055/s-0032-1314853 2012
Comparative fasting bioavailability and pharmacokinetic properties of 2 formulations of glucosamine hydrochloride in healthy Chinese adult male volunteers [0.03%]
两种盐酸葡萄糖胺制剂在中国健康男性受试者中空腹生物等效性及药代动力学研究
H Wu,M Liu,S Wang et al.
H Wu et al.
Glucosamine (CAS 66-84-2) hydrochloride is an amino monosaccharide indicated for the treatment of arthrosis, especially osteoarthritis of the knee joint. This study was conducted to assess and compare the pharmacokinetic (PK) properties, bi...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Aug;62(8):367-71. DOI:10.1055/s-0032-1312650 2012