The preventive oral supplementation of a selenium nanoparticle-enriched probiotic increases the immune response and lifespan of 4T1 breast cancer bearing mice [0.03%]
富硒纳米粒子益生菌的预防性补充可增强4T1乳腺癌小鼠的免疫反应和延长其寿命
M H Yazdi,M Mahdavi,E Kheradmand et al.
M H Yazdi et al.
The immunomodulatory effects of lactic acid bacteria have been demonstrated previously. In this study, a Lactobacillus plantarum strain was selected and enriched with selenium nanoparticles for use as a new immunomodulating agent in a breas...
Ibudilast, a phosphodiesterase inhibitor, in combination with low-dose aspirin potently inhibits guinea pig carotid artery thrombosis without extending bleeding time and causing gastric mucosal injury [0.03%]
一种磷酸二酯酶抑制剂伊布利特联合小剂量阿司匹林可强力抑制颊猴颈动脉血栓形成，并具有不出血和不损伤胃粘膜的优点
S Matsuzawa,K Hoshina,S Sueyoshi et al.
S Matsuzawa et al.
A combination of low-dose aspirin (ASA) and a phosphodiesterase inhibitor has been clinically tried for the secondary prevention of atherothrombotic diseases. The in vivo antithrombotic property of ibudilast (CAS 50847-11-5), a phosphodiest...
CYP2C9*3(1075A>C), MDR1 G2677T/A and MDR1 C3435T are determinants of inter-subject variability in fluvastatin pharmacokinetics in healthy Chinese volunteers [0.03%]
在中国健康志愿者中，CYP2C9*3(1075A>C)，MDR1 G2677T/A 和 MDR1 C3435T 是氟伐他汀药动学的个体间差异决定因素
Q Zhou,Z-r Ruan,H Yuan et al.
Q Zhou et al.
To evaluate the impact of single-nucleotide polymorphisms (SNPs) in CYP2C9, MDR1, SLCO1B1 and ABCG2 on the pharmacokinetics of fluvastatin in Chinese participants.A pharmacokinetic study of fluvastatin (single dose 40 mg) was conducted in 1...
The inhibition of monoamine oxidase by 8-(2-phenoxyethoxy)caffeine analogues [0.03%]
8-(2-苯氧乙基)-咖啡因类似物的单胺氧化酶抑制作用
B Strydom,J J Bergh,J P Petzer
B Strydom
Previous studies have documented that substituted 8-oxycaffeines act as inhibitors of human monoamine oxidase (MAO) B. A particularly potent inhibitor among the reported compounds was 8-(2-phenoxyethoxy)caffeine with an IC50 value of 0.383 ...
Development and validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous determination of acrivastine and pseudoephedrine in human plasma and its application in pharmacokinetics [0.03%]
用于人体血浆中阿司维林和伪麻黄碱的同时检测的液相色谱-串联质谱法的开发与验证及其在药代动力学中的应用
J-C He,E-F Feng,M Liu et al.
J-C He et al.
A specific, sensitive and accurate liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed for the simultaneous determination of acrivastine and pseudoephedrine in human plasma samples. Plasma samples were proces...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Oct;62(10):449-56. DOI:10.1055/s-0032-1314877 2012
Bioequivalence of lamotrigine 50-mg tablets in healthy male volunteers: a randomized, single-dose, 2-period, 2-sequence crossover study [0.03%]
拉莫三嗪50毫克片剂的人体生物等效性试验：健康男性志愿者单剂量双周期双序交叉试验
S Perez-Lloret,L Olmos,F de Mena et al.
S Perez-Lloret et al.
OBEJCTIVE: To compare the bioavailability of two 50-mg lamotrigine dispersible tablet formulations (Epilepax®, Ivax-TEVA Argentina Laboratories, Argentina, as a test formulation, and Lamictal®, GlaxoSmithKline, UK, as a reference formulat...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Oct;62(10):470-6. DOI:10.1055/s-0032-1321859 2012
Pharmacokinetics and bioequivalence of 2 tablet formulations of olanzapine in healthy Chinese volunteers: a randomized, open-label, single-dose study [0.03%]
奥氮平两种片剂制剂在中国健康志愿者中的药代动力学和生物等效性：一项随机、开放标记、单次给药研究
Q Chen,M-q Zhang,Y Liu et al.
Q Chen et al.
Olanzapine is a widely used agent for the treatment of schizophrenia.The aim of this study was to evaluate bioequivalence of two 10-mg tablet formulations of olanzapine following single oral dose in adult male volunteers.This was a randomiz...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Nov;62(11):508-12. DOI:10.1055/s-0032-1323659 2012
Synthesis and pharmacological investigation of 5-substituted-3-methylsulfanyl-1H-pyrazole-4-carboxylic acid ethyl esters as new analgesic and anti-inflammatory agents [0.03%]
一类新型镇痛抗炎药——5-取代-3-甲硫基-1H-吡唑-4-羧酸乙酯的合成及药理学研究
P D Gokulan,B Jayakar,V Alagarsamy et al.
P D Gokulan et al.
Purpose: To synthesize a new series of 5-substituted-3-methylsulfanyl-1H-pyrazole-4-carboxylic acid ethyl esters for their analgesic and anti-inflammatory activity. ...
Effects of milk casein derived tripeptides on endothelial enzymes in vitro; a study with synthetic tripeptides [0.03%]
酪蛋白三肽对内皮细胞酶活性影响的体外研究及人工合成三肽的研究
A Siltari,A S Kivimäki,P I Ehlers et al.
A Siltari et al.
In the fermentation of milk by certain lactic acid bacteria, casein is degraded into bioactive tripeptides shown to lower blood pressure in experimental animal models and in mildly hypertensive humans. This effect is suggested to result mai...
Development of a subcutaneous formulation for trastuzumab - nonclinical and clinical bridging approach to the approved intravenous dosing regimen [0.03%]
一种曲妥珠单抗皮下给药制剂的开发——非临床和临床研究连接批准的静脉给药方案的方法
B Bittner,W F Richter,F Hourcade-Potelleret et al.
B Bittner et al.
A subcutaneous (SC) formulation has been developed for the humanized monoclonal antibody (mAb) trastuzumab as an alternative to established intravenous (IV) infusion. The ready-to-use liquid SC formulation is injected as a fixed dose in app...