Antimicrobial and cytotoxicity potential of acetamido, amino and nitrochalcones [0.03%]
乙酰氨基、氨基和硝基查尔酮的抗菌和细胞毒性潜力
T C Tristão,F Campos-Buzzi,R Corrêa et al.
T C Tristão et al.
Chalcones constitute one of the major classes of natural products belonging to the flavonoid family, and they have been reported as having a range of important therapeutic activities, including some chalcones are effective as antimicrobial ...
Microwave-assisted synthesis of 1,3-benzothiazol-2(3H)-one derivatives and analysis of their antinociceptive activity [0.03%]
微波促进1,3-苯并噻唑-2(3H)-酮衍生物的合成及其镇痛活性分析
T Onkol,Y Dündar,E Yıldırım et al.
T Onkol et al.
A rapid and efficient method was developed for synthesis of 6-acyl-1,3-benzothiazol-2(3H)-one derivatives under microwave irradiation (MWI) conditions. The reaction times were shortened compared to conventional heating. Additionally, we syn...
Development and Validation of a Liquid Chromatography-tandem Mass Spectrometry Method for the Simultaneous Determination of Acrivastine and Pseudoephedrine in Human Plasma and its Application in Pharmacokinetics [0.03%]
高效液相色谱-串联质谱法测定人血浆中阿司匹林特丁醇和伪麻黄碱的方法及应用研究
J-C He,E-F Feng,M Liu et al.
J-C He et al.
Pharmacokinetics and bioequivalence evaluation of two brands of ciprofloxacin 500 mg tablets in Iranian healthy volunteers [0.03%]
两种环丙沙星500毫克片剂的品牌在伊朗健康志愿者中的药代动力学和生物等效性评估
H Valizadeh,H Hamishehkar,S Ghanbarzadeh et al.
H Valizadeh et al.
In the present study pharmacokinetics and bioequivalence of 2 brands of ciprofloxacin 500 mg were evaluated in 24 healthy male volunteers after a single dose oral administration in an open, randomized, 2-way crossover study.Blood samples we...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Dec;62(12):566-70. DOI:10.1055/s-0032-1327571 2012
Pharmacokinetics and safety of eszopiclone in healthy Chinese volunteers [0.03%]
艾司佐匹克隆在健康中国受试者中的药代动力学和安全性研究
F Wu,X L Zhao,M J Wei et al.
F Wu et al.
The main objective of this study was to investigate the pharmacokinetic characters of eszopiclone (CAS: 138729-47-2) after single and multiple-dose oral administration in healthy adult Chinese volunteers.In single-dose study, 12 subjects we...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Dec;62(12):561-5. DOI:10.1055/s-0032-1327570 2012
Dapson in heterocyclic chemistry part VI: synthesis and molecular docking of some novel sulfonebiscompounds of expected anticancer activity [0.03%]
偶氮在杂环化学中的应用第六部分：一些具有抗癌活性的新型砜化合物的合成及分子对接研究
M M Ghorab,M S Al-Said,Y M Nissan
M M Ghorab
To discover new bioactive lead compounds for medicinal purposes, herein, sulfone biscompounds bearing dihydrothiazoles (3-9, 14, 15), acrylamide (11), thiazolidinones (12, 13, 20), thiophenes (16, 17) and benzothiophene (19) were prepared a...
Virtual screening and synthesis of new chemical scaffolds as VEGFR-2 kinase inhibitors [0.03%]
作为VEGFR-2激酶抑制剂的新化学支架的虚拟筛选和合成
M S Elsayed,M E El-Araby,R T Serya et al.
M S Elsayed et al.
VEGFR-2 tyrosine kinase inhibitors are currently receiving high interest in drug discovery process as anticancer agents. We have used virtual screening techniques in order to discover new scaffolds that can be used for developing new VEGFR-...
Synthesis and biological evaluation of a 6-aminofuro[3,2-c]pyridin-3(2H)-one series of GPR 119 agonists [0.03%]
一类G蛋白偶联受体119激动剂的合成与活性研究
M Sakairi,M Kogami,M Torii et al.
M Sakairi et al.
G protein-coupled receptor 119 (GPCR 119 (GPR119)) agonists have received considerable attention as a promising therapeutic option for treatment of type 2 diabetes mellitus. GPR119 is one of the GPCRs expressed in pancreatic islet β-cells ...
M F Zayed,R R Ayyad
M F Zayed
A series of phthalazinedione bearing substituted oxadiazole moiety derivatives X(1-7) were synthesized in good yield and evaluated for their possible anticonvulsant activity. The structures of the synthesized compounds were confirmed on the...
X-X Liu,R-J Liu,L Ding et al.
X-X Liu et al.
Background: Febuxostat is a novel non-purine selective inhibitor of xanthine oxidase developed for the management of hyperuricemia in patients with gout. ...