Repeated administration of centhaquin to pregnant rats did not affect postnatal development and expression of endothelin receptors in the brain, heart or kidney of pups [0.03%]
重复给怀孕大鼠服用中quoine未能影响幼鼠出生后的发育及其脑、心或肾中的内皮素受体的表达
S Briyal,M S Lavhale,A Gulati
S Briyal
The effect of repeated administration of centhaquin to pregnant rats on postnatal development, and expression of ETA and ETB receptors was determined. Pregnant rats were treated daily with either saline or centhaquin for 2 weeks. Male rat p...
Simultaneous determination of methotrexate, dasatinib and its active metabolite N- deshydroxyethyl dasatinib in rat plasma by LC-MS/MS: method validation and application to pharmacokinetic study [0.03%]
一种同时测定大鼠血浆中甲氨蝶呤、达沙替尼及其活性代谢产物N-脱乙氧基甲基达沙替尼方法学研究及应用
S R S Thappali,K V S Varanasi,S Veeraraghavan et al.
S R S Thappali et al.
Dasatinib is a multi-kinase inhibitor that potently inhibits Bcr-Abl, Src family and platelet-derived growth factor receptor kinases. Methotrexate is an antimetabolite and antifolate drug. Clinical trials utilizing a combination of dasatini...
A parallel design study to assess the bioequivalence of generic and branded hydroxychloroquine sulfate tablets in healthy volunteers [0.03%]
健康志愿者中硫酸羟氯喹片仿制药与原研药生物等效性平行设计研究
Y-M Liu,Q Chen,M-Q Zhang et al.
Y-M Liu et al.
Hydroxychloroquine (HCQ) is a racemic 4-aminoquinoline derivative that was first introduced as an antimalarial, and subsequently applied to the treatment of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. ...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Dec;62(12):644-9. DOI:10.1055/s-0032-1329962 2012
P Ratajczak,K Kus,Z Jarmuszkiewicz et al.
P Ratajczak et al.
Alcoholism is a mental disease in the course of which depression, anxiety, and cognitive function deficits may appear, and these symptoms can be aggravated by comorbid schizophrenia.The aim of this study was to find whether spatial memory (...
Neuroprotective action and free radical scavenging activity of Guttiferone-A, a naturally occurring prenylated benzophenone [0.03%]
一种天然倍半萜苯醌衍生物 Gutteferone-A 的神经保护作用和清除自由基活性研究
Y Nuñez-Figueredo,L García-Pupo,J Ramírez-Sánchez et al.
Y Nuñez-Figueredo et al.
Reactive oxygen species (ROS) are important mediators in a number of neurodegenerative diseases and molecules capable of scavenging ROS may be a feasible strategy for protecting neuronal cells. We previously demonstrated a powerful iron-che...
H Song,F Bu,C Wei et al.
H Song et al.
A liquid chromatography-mass spectrometry method was developed, validated, and applied to the pharmacokinetic study with doses of 0.68, 2.73 and 10.92 mg/kg of ginkgolide B in beagle dogs after intravenous infusion.An aliquot of blood sampl...
LC-MS/MS method for determination of epothilone B in rat plasma and its application in pharmacokinetic study [0.03%]
大环内酯类抗生素 epoxythilon B 的药代动力学行为研究
H-M Lu,M Ye
H-M Lu
A simple LC-MS/MS method was developed for determination and pharmacokinetic study of Epothilone B in rat plasma.Plasma sample pretreatment involved a one-step liquid-liquid extraction of 100 µL plasma. The chromatographic separation was c...
In vitro dissolution and in vivo bioequivalence evaluation of two brands of isosorbide 5-mononitrate sustained release tablets [0.03%]
异山梨酯5-单硝酸盐缓释片两种品规的体外溶出及生物等效评价
Y-H Kim,K-S Choi,S-H Kam et al.
Y-H Kim et al.
The purpose of the present study was to test a sustained release-tablet newly formulated with synthetic paraffin and compare its bioequivalence to that of the Imdur® Long-Acting tablet, based on the guidelines of the Korean Food and Drug A...
Comparative Study
Arzneimittel-Forschung. 2012 Dec;62(12):576-82. DOI:10.1055/s-0032-1327614 2012
Interaction of 5-amino-1,3,4-thiadiazole-2-thiol and its violuric acid adduct with Pt(II) - crystals structures, spectroscopic properties and cytotoxic activity [0.03%]
5-氨基-1,3,4-噻二唑-2-硫醇及其与Pt(II)的紫尿酸加成物的相互作用：晶体结构、光谱性质及细胞毒活性
M Kavlakova,A Bakalova,G Momekov et al.
M Kavlakova et al.
The coordination properties of Pt(II) with 5-amino-1,3,4-thiadiazole-2-thiol [CAS 2349-67-9] (L 1 ) and its novel violurate adduct (L 2 ), both in solution and in solid state, are studied by means of conventional IR-spectroscopy, single cry...
Ketorolac tromethamine improves the analgesic effect of hyoscine butylbromide in patients with intense cramping pain from gastrointestinal or genitourinary origin [0.03%]
酮咯酸氨丁三醇可改善氢溴酸东莨菪碱对胃肠或泌尿系统痉挛性疼痛的镇痛效果
C F del Valle-Laisequilla,F J Flores-Murrieta,V Granados-Soto et al.
C F del Valle-Laisequilla et al.
The symptomatic treatment of pain associated with spasm of gastrointestinal or genitourinary origin can include the use of spasmolytic agents and/or non-steroidal anti-inflammatory drugs. However, the evidence of a superior effectiveness of...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Dec;62(12):603-8. DOI:10.1055/s-0032-1327678 2012