Contribution of formulation and excipients towards enhanced permeation of curcumin [0.03%]
制剂与辅料在增强姜黄素渗透性方面的贡献
B Wahlang,D Kabra,Y B Pawar et al.
B Wahlang et al.
Curcumin (CRM) (CAS number 458-37-07), a naturally-occurring molecule, has diverse pharmacological actions. Recently our research group demonstrated that poor permeability also contributes to its poor oral bioavailability. A self nano-emuls...
A simple LC-MS/MS method for determination of magnolol in rat blood and its application in a pharmacokinetic study [0.03%]
一种简单的测定大鼠血液中Magnolol含量的LC-MS/MS方法及其在药代动力学研究中的应用
H Li,X-S Wen,W Di
H Li
A simple LC-MS/MS method was developed for determination and pharmacokinetic study of magnolol in rat blood. Blood sample pretreatment involved a one-step extraction with methanol of 100 µL blood. The chromatographic separation was carried...
Pharmacokinetics, pharmacodynamics, and tolerability of a generic formulation of exenatide: a randomized, open-label, single- and multiple-dose study in healthy Chinese volunteers [0.03%]
一项在健康中国受试者中评估艾塞那肽仿制制剂药代动力学、药效学和耐受性的随机开放标签单次及多次给药研究
S Shi,Y Liu,Z Li et al.
S Shi et al.
A randomized, open-label, dose-escalating study was designed to assess the pharmacokinetics, pharmacodynamics and tolerability of single and multiple subcutaneous administrations of exenatide in 24 healthy Chinese volunteers. The effects of...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Feb;62(2):75-82. DOI:10.1055/s-0031-1295484 2012
Design, synthesis and evaluation of novel benzimidazoles, benzothiazoles and benzofurans incorporating pyrazole moiety as antiangiogenic agents [0.03%]
一类新型含吡唑类苯并咪唑、苯并噻唑和苯并呋喃衍生物的抗血管新生剂的设计、合成与活性研究
S M Rida,A M Youssef,M H Badr et al.
S M Rida et al.
Novel benzimidazoles, benzothiazoles and benzofurans incorporating pyrazole moiety have been synthesized and screened for their antiangogenic activities, by testing their ability to inhibit human umbilical vein endothelial cell (HUVEC) prol...
Bioequivalence study of 2 orodispersible formulations of ondansetron 8 mg in healthy volunteers [0.03%]
富马酸奥曲肽缓释微球注射剂在中国健康受试者体内的药代动力学研究及与瑞士进口商品化奥曲肽的生物等效性研究：I期临床试验报告
M Cánovas,J Rios,G Domenech et al.
M Cánovas et al.
This study was designed to compare the rate and extent of absorption of 2 oral formulations of ondansetron (CAS 99614-02-5) 8 mg orodispersible tablets in healthy volunteers. 22 subjects were administered ondansetron orodispersible tablets ...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Feb;62(2):59-62. DOI:10.1055/s-0031-1295488 2012
The pharmacological profile and clinical use of mesalazine (5-aminosalicylic acid) [0.03%]
美沙拉秦(5-氨基水杨酸)的药理学特点及其临床应用
U Klotz
U Klotz
For more than 30 years mesalazine (5-aminosalicylic acid; 5-ASA) has been used for the treatment of chronic inflammatory bowel disease (IBD) especially in ulcerative colitis (UC). During this time various rectal and oral formulations have b...
Reversal of oxidative stress by histamine H₃ receptor-ligands in experimental models of schizophrenia [0.03%]
组胺H₃受体配体逆转精神分裂症模型中的氧化应激损伤
D Mahmood,R Khanam,K K Pillai et al.
D Mahmood et al.
Schizophrenia (SCZ) is a debilitating disorder afflicting around 1% of the world population. Recent literature reveals oxidative injuries contribute enormously to the pathophysiology of SCZ alongside other psychopathological disturbances. H...
Synthesis, in-vitro anticancer screening and radiosensitizing evaluation of some new N-(quinoxalin-2-yl)benzenesulfonamide derivatives [0.03%]
新N-（喹唑啉-2-基）苯磺酰胺衍生物的合成、体外抗癌筛选及增敏评价
M M Ghorab,F A Ragab,H I Heiba et al.
M M Ghorab et al.
The objective of this work is to synthesize and investigate the anticancer activity of a new series of sulfaquinoxaline derivatives by incorporating biologically active moieties (thiourethane, thiazole, imidazole, imidazopyrimidine, imidazo...
Effect of gemfibrozil on the pharmacokinetics of mitiglinide in rats [0.03%]
吉非罗齐对米格列奈药代动力学的影响研究(英文)
L Jin,Q Cao
L Jin
A sensitive and specific method was developed and validated for the determination of mitiglinide in plasma using LC-MS/MS. The effect of gemfibrozil on the pharmacokinetics of orally administered mitiglinide in rats was investigated. The va...
Bioequivalence of two misoprostol tablets in healthy Chinese female volunteers: a single-dose, two-period, double crossover study [0.03%]
两种米索前列醇片在中国健康女性受试者中的生物等效性单剂量、两周期双交叉试验
J Huang,R Chen,R Li et al.
J Huang et al.
Objective: To assess the bioequivalence of a new generic formulation of misoprostol (CAS 59122-46-2) 0.2 mg tablets (test) and the available branded tablet (reference) for the requirement of state regulatory criteria and ...
Randomized Controlled Trial
Arzneimittel-Forschung. 2012 Jan;62(1):35-9. DOI:10.1055/s-0031-1295426 2012