Inter-relational dynamics of factors affecting the emergence of orphan drugs [0.03%]
影响孤儿药出现的因素的相互作用关系动力学分析
Rinchen Gensapa,Vivek Pandey,Saibal Kumar Saha et al.
Rinchen Gensapa et al.
Orphan drugs are medications that are produced for the treatment of rare diseases. As there is less number of patients, the drug manufacturing companies are not keen in producing these drugs. Due to high costs of research and development an...
[Emergence of antifungal resistance: A creeping environmental threat?] [0.03%]
[抗真菌药物耐药性的产生：一场悄无声息的环境威胁？]
Guillaume Decocq,Jean-Noël Colin,Anne-Lise Bienvenu
Guillaume Decocq
Antifungal resistance in humans is a clinical reality of increasing incidence that raises problems for patient care. In this current event, we discuss the link that can be made between the presence of antifungals in the environment and the ...
Polysaccharide-based implant drug delivery systems for precise therapy: Recent developments, and future trends [0.03%]
基于多糖的植入控释系统精准治疗：近年来的研究进展与未来趋势
Suraj Kumar,Rishabha Malviya,Sathvik Belagodu Sridhar et al.
Suraj Kumar et al.
Implantable drug delivery systems offer numerous benefits, including effective drug administration at lower concentrations, fewer side effects, and improved patient compliance. Various polymers are used for fabricating implants, with biopol...
Amorolfine hydrochloride loaded solid lipid nanoparticles: Preparation, characterization and ex vivo nail permeation study to treat onychomycosis [0.03%]
盐酸阿莫洛芬固体脂质纳米粒的制备、表征及透甲实验研究
Tasleem Ahmed,Nithya Shanthi,Arun Kumar Mahato
Tasleem Ahmed
Onychomycosis is a disease of the nail plate caused by fungi, leading to the progressive defacing of the nail. The infection requires a longer period of treatment orally and topically. The treatment with the topical route is difficult due t...
Handling and decontamination of live medications: What challenges for hospital pharmacies in France? [0.03%]
活生物制剂的处理及除污染：法国医院药房面临哪些挑战？
Adélie Riazi,Élodie Allouis,Céline Sakr et al.
Adélie Riazi et al.
Objectives: To review the literature and national practices concerning the handling and decontamination of live medications, in order to revise our local practices. ...
Ilona Béatrix,Elsa Bonnabry,Suzanne Atkinson et al.
Ilona Béatrix et al.
Context: Drug shortages impact patients from all countries. According to the Pharmaceutical Group of the European Union, most Europe countries reported a worsening of shortages in 2023. ...
Development of mesalamine loaded-fenugreek gum decorated pectin microspheres for colonic drug delivery: Ex-vivo and in-vitro characterizations [0.03%]
用于结肠药物递送的装载美沙拉秦的葫芦巴胶接枝果胶微球的开发：体外和离体表征
Pruthvi P Khamkar,Kalpeshkumar S Wagh,Sopan N Nangare et al.
Pruthvi P Khamkar et al.
Mesalamine (MES) is a preferred therapeutic agent for managing various colon disorders, including inflammatory bowel diseases (IBD). However, conventional oral dosage forms of MES face significant limitations, which reduce their effectivene...
Validation of spectrophotometric and colorimetric method for the specific quantification of sofosbuvir From luminar capsule microneedle in liver tissue through ex vivo and in vivo applications [0.03%]
体外和体内实验验证兰尼慕司胶囊微针中索夫布韦分光光度法和比色法的特异性量化
Abigael Alik Samma,Christopher Kosasi Ko,Musyfira Sahra et al.
Abigael Alik Samma et al.
An antiviral prodrug that has received regulatory approval and primarily employed in the treatment of hepatitis C is sofosbuvir (SOF). It is therefore imperative to develop advanced delivery methods for SOF in order to address existing abso...
The therapeutic potential of Ribes orientale in hypertension: Improving electrolyte balance, enhancing antioxidant activity, and modulating the muscarinic pathway [0.03%]
东方醋栗在高血压治疗中的潜力：改善电解质平衡，增强抗氧化活性和调节毒蕈碱途径
Ambreen Malik Uttra,Suhail Ahmad,Taseer Ahmad et al.
Ambreen Malik Uttra et al.
Cardiovascular diseases like hypertension require diuretics, but their effectiveness and side effects limit their use. Alternatives like Ribes orientale extract are being investigated for potential diuretic. In acute diuretic action, the ex...
The implications of the EU ban on titanium dioxide: A comprehensive review of safety concerns and alternatives [0.03%]
欧盟二氧化钛禁令的含义：安全问题及替代品的全面回顾
Varsha Pokharkar,Sejal Chandak,Rutika Pawar et al.
Varsha Pokharkar et al.
Titanium dioxide, a naturally occurring compound, has been extensively utilized across various industries such as food, pharmaceuticals, and cosmetics. In the food sector, it was commonly employed as a color and opacity enhancer under the d...