PLAROsomes as a Modified Liposomes Delivery System for Mimosa pudica L. Extract: Augmenting Anticancer Potential Against Prostate and Skin Cancer Cell Lines [0.03%]
改良后的脂质体递送系统PLARoSomes：含含羞草提取物的抗癌潜力增强子，用于前列腺和皮肤癌细胞系治疗
Vaishali K Gaikwad,Ravindra B Laware,Nitin Mohire et al.
Vaishali K Gaikwad et al.
Objective: PLAROsomes, a modified liposomal drug carrier system, were developed to overcome the major drawback of drug leakage in conventional liposomes. This study aimed to encapsulate Mimosa pudica L. extract (MIPA) wit...
[Pharmaceutical preparations in the management of medicine shortages at the French National Agency for Medicines and Health Products Safety] [0.03%]
[法国国家医药产品安全局管理药品短缺的药剂准备]
Martine Bouley,Brigitte Rogeau,Roseline Mazet et al.
Martine Bouley et al.
Objectives: Among the actions implemented by the French National Agency for Medicines and Health Products Safety to manage drug shortages, the use of pharmaceutical preparations can be a solution, as a relay, when feasibl...
Francis Megerlin,Gilles Bouvenot,Patrice Queneau
Francis Megerlin
Deprescribing inappropriate drug treatments is a public health issue particularly in countries with a high level of polymedication (polypharmacy). Despite the introduction of the term 'deprescribing' in France in 2002 and the clinical pract...
Ethyl Cellulose-Based In-Situ Film of Itraconazole for Enhanced Treatment of Fungal Infections [0.03%]
伊曲康唑以乙基纤维素为基础的原位薄膜增强真菌感染治疗
Lutfi Chabib,Yulianto,Putri Wulandari Resky Ananda et al.
Lutfi Chabib et al.
Objectives: Fungal infections represent a significant global health challenge, requiring effective treatments to prevent complications and improve patient outcomes. This study aimed to develop an in-situ film-forming syst...
Profilage chimio-informatique des composés phytochimiques d'Azardirachta indica en tant qu'inhibiteurs oncogènes doubles SHP2/HSP90: identification du nimbocinol, de la nimbidinine et de la margolone [0.03%]
基于化学信息学的 chinje 化合物筛选及其作为双靶点(SHP2/HSP90)抗癌抑制剂的鉴定：尼姆酚、尼宾丁和马格洛林
Oluwaseun E Agboola,Zainab A Ayinla,Oladayo Apalowo et al.
Oluwaseun E Agboola et al.
Cancer therapy faces challenges due to drug resistance and signalling pathway redundancy. Dual inhibition of SHP2 (Src homology region 2 domain-containing phosphate-2) and HSP90 (heat shock protein 90) offers a promising strategy to overcom...
The paradigm shift from Stringent Regulatory Authorities to WHO-Listed Authorities [0.03%]
从严格监管机构到世界卫生组织列出的权威机构的范式转变
Valérie Faillat
Valérie Faillat
Regulatory systems play a key role in assuring the quality, safety, and efficacy of health products. After more than 20 years of efforts on regulatory capacity improvement of the less-equipped National Regulatory Authorities, the transition...
Development and Validation of a Novel Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) Method for the Quantification of Related Substances of Vasopressin Injection: A Characterization and Comparative Analysis of Vasopressin Formulation Samples against Vasostrict (RLD) in Various Diluents [0.03%]
一种新的反相高效液相色谱法(RP-HPLC)测定加压素注射剂有关物质的方法学研究及建立：与进口原料药Vasostrict对比分析多种溶媒中加压素制剂样品的表征及比较分析
Sivaji Maganti,Suryakala Duvvuri,Prudhvi Raju Pericharla et al.
Sivaji Maganti et al.
In the present study, we developed and validated a sensitive, accurate, robust and simple RP-HPLC method for quantification of related substances of Vasopressin (VPS) injection. The development phase prioritized the optimization of waveleng...
Formulation of repurposed celecoxib-loaded nanostructured lipid carriers using Box Behnken design, its characterization, and anticancer evaluation [0.03%]
复用的塞来考昔负载纳米结构脂质载体的配方（使用Box Behnken设计）、表征及其抗癌评价
Ashwini Bhavar,Kaustubh Ajit Kolekar,Tejashree Yadav et al.
Ashwini Bhavar et al.
Objectives: The key objective of present research is to effectively treat lung cancer with repurposed celecoxib while overcoming challenges such as solubility, bioavailability, non-selectivity, and negative effects by del...
Formulation and Evaluation of a Smart Mucoadhesive Nasal Gel Containing Oregano, Chamomile, and Lavender for Seizure Control in PTZ-induced seizure models in rats [0.03%]
含有牛至、甘菊和薰衣草的智能粘膜鼻用凝胶的配方及评估：在PTZ诱导的大鼠癫痫模型中用于控制癫痫发作
Samin Sheikholeslami,Amir Baghaei,Marziyeh Amiri-Andebili et al.
Samin Sheikholeslami et al.
Background: Epilepsy is a prevalent neurological disorder characterized by recurrent seizures, affecting approximately 1% of the global population. Despite the availability of antiepileptic drugs, a significant proportion...
[The medical biologist "under the microscope" : analysis of digital images depicting laboratory medicine] [0.03%]
显微镜下的医疗生物学家：“实验室医学”数字图像分析
Bertrand Lefrère,Lionel Barrand,Jean-Louis Beaudeux
Bertrand Lefrère
In France, the practice of laboratory medicine has, over the past ten years or so, met with a certain amount of disenchantment from medical students. Despite its intricacy and importance to healthcare, the world of the clinical laboratory l...