[PEDIAB'AIDE: a pediatric diabetes training tool for the pharmacy team] [0.03%]
[儿科糖尿病培训工具PEDIAB'AIDE用于药学团队]
Elise Conand,Sabine Baron,Sonia Prot-Labarthe
Elise Conand
Introduction: In 2023, type 1 diabetes (T1DM) affected more than 31,000 young people under the age of 20 in France, with the number of new cases rising every year. The onset of the disease is acute and abrupt in children,...
Lactate is a prognostic marker of acute liver failure in early identification of patients susceptible to liver transplantation following acute acetaminophen poisoning [0.03%]
乳酸是急性肝功能衰竭的预后标志物，在早期识别出阿司匹林中毒后易发展为需要肝脏移植患者的指标
Masoumeh Ebrahimi Medisah,Mahdieh Sadat Badiee,Masoud Mahdavinia et al.
Masoumeh Ebrahimi Medisah et al.
Background: Acetaminophen (APAP) is the most commonly used analgesic and antipyretic drug, and its intentional or accidental overdose can lead to acute liver failure (ALF). Rapid prognosis and the selection of appropriate...
In Pursuit of Software Solutions for Pharmaceutical Regulatory Affairs: Insights and Trends [0.03%]
追索药物监管事务的软件解决方案：见解与趋势
Shrushti Sharma,Dyandevi Mathure,Shreyas Dingankar et al.
Shrushti Sharma et al.
With rapid upsurge in technology and digital tools, the existing systems including the healthcare systems, especially the pharmaceutical sector is experiencing the revolution in the flow and management of data. Use of digital tools in pharm...
[Risks associated with the implementation of a nominative unit-dose dispensing robotic system: analysis after ten years of use within a hospital pharmacy department] [0.03%]
[实施命名单位剂量机器人发药系统的风险分析：医院十年应用的药学经验]
Thiec Julie,Malet Delphine,Colombe Anne et al.
Thiec Julie et al.
Objectives: Our hospital pharmaceutical department acquired an automated drug dispensive system to secure the medication management, from the dispensation to the administration process. The aim of our study was to secure ...
ICH Q3D based elemental impurities study in an oral drug product: risk assessment according to component approach (option 2b) confirmed by finished product analysis (option 3) [0.03%]
基于ICH Q3D元素杂质研究的口服固体制剂风险评估及成品测定研究报告
Ayoub Hamidallah,Mohamed Yafout,Ibrahim Sbai El Otmani
Ayoub Hamidallah
Background: Elemental impurities (EIs) in pharmaceutical products pose potential health risks, requiring strict regulatory control. The ICH Q3D guideline outlines two approaches for assessing EIs: the component approach, ...
Synergistic Anticonvulsant Activity of Oregano, Chamomile, and Lavender via Intranasal Administration: A Dose-Response Modeling Approach [0.03%]
鼻腔给药的百里香，洋甘菊和薰衣草的协同抗惊厥活性：剂量反应建模方法
Samin Sheikholeslami,Marziyeh Amiri-Andebili,Amir Baghaei et al.
Samin Sheikholeslami et al.
Background: This short communication presents an analytical approach to evaluate the synergistic anticonvulsant effects of an herbal combination containing hydroalcoholic extracts of Origanum vulgare (oregano), Matricaria...
Release of Chlororotetracycline Hydrochloride From Novel Hydrogels Based On Crosslinked Chitosan And PVA [0.03%]
基于交联壳聚糖和PVA的新型水凝胶氯四环素盐的释放性能研究
Mohammed Amine Zitouni,Mustapha Chabane,Melkaoui Chikh
Mohammed Amine Zitouni
Hydrogels based on hydrochloride polyvinyl alcohol (PVA) containing chlortetracycline and crosslinked chitosan (CS) by Glutaraldehyde (GLA) were prepared by the freeze-thawing method and then characterized. The swelling properties and gel f...
Immunosubstitution of patients with refractory multiple myeloma treated with Teclistamab, a bispecific antibody [0.03%]
替西扎马布治疗难治多发性骨髓瘤患者的免疫替代疗法
Bros Ariane,Harel Stéphanie,Arnulf Bertrand et al.
Bros Ariane et al.
Multiple myeloma (MM) is the 2nd most common haematological malignancy in France, and its treatment has been improved in recent years by the arrival of new therapies such as CAR-T cells and bispecific antibodies. Among the latter, teclistam...
Theobromine as a Multi-Target Therapeutic Agent: Analgesic, Anti-Inflammatory, and Anti-Arthritic Potential with Network Pharmacology Insights [0.03%]
茶碱作为多靶点治疗药物的潜力：网络药理学见解下的镇痛、抗炎和抗关节炎作用
Hafiza Sara Afzal,Ambreen Malik Uttra,Sumera Qasim et al.
Hafiza Sara Afzal et al.
Objective: Inflammatory disorders, including rheumatoid arthritis (RA) and osteoarthritis, contribute significantly to global health burdens. Theobromine, a xanthine alkaloid present in cocoa, has pharmacological properti...
Unspecified Degradation Impurities Identification and Characterization in Bilastine and Montelukast tablet formulations by using UPLC and LCMS/MS: Robustness by Design Expert and Green assessment [0.03%]
基于UPLC和LCMS/MS的比拉斯汀和蒙特鲁卡斯片剂中不确定降解杂质的识别与表征：由DOE方法评估其稳健性和绿色度
Raj Kumar Kodishala,Kousrali Sayyad,Leela Prasad Kowtharapu et al.
Raj Kumar Kodishala et al.
Objectives: This study introduces a novel ultraperformance liquid chromatography (UPLC) method for the rapid, simple, and accurate detection of contaminants in bilastine (BLS) and montelukast (MTK) tablet formulations. ...