Drop Printing of Pharmaceuticals: Effect of Molecular Weight on PEG Coated-Naproxen/PEG3350 Solid Dispersions [0.03%]
分子量对PEG包覆的萘普生/聚乙二醇固体分散物滴打印的影响研究
Hsin-Yun Hsu,Scott Toth,Garth J Simpson et al.
Hsin-Yun Hsu et al.
Solid dispersions have been used to enhance the bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). However, the solid state phase, compositional uniformity, and scale-up problems are issues that need to be add...
Mimicking Biological Delivery Through Feedback-Controlled Drug Release Systems Based on Molecular Imprinting [0.03%]
基于分子印迹的反馈控制药物释放系统模仿生物递送
David R Kryscio,Nicholas A Peppas
David R Kryscio
Intelligent drug delivery systems (DDS) are able to rapidly detect a biological event and respond appropriately by releasing a therapeutic agent; thus, they are advantageous over their conventional counterparts. Molecular imprinting is a pr...
Evaluation of Nanoparticle Tracking for Characterization of Fibrillar Protein Aggregates [0.03%]
纳米颗粒跟踪分析技术表征纤维状蛋白质聚集体性能的评估
Dennis T Yang,Xiaomeng Lu,Yamin Fan et al.
Dennis T Yang et al.
Amyloidogenesis is the process of formation of protein aggregates with fibrillar morphology. Because amyloidogenesis is linked to neurodegenerative disease, there is interest in understanding the mechanism of fibril growth. Kinetic models o...
Ryan E Cobb,Ran Chao,Huimin Zhao
Ryan E Cobb
Directed evolution, the laboratory process by which biological entities with desired traits are created through iterative rounds of genetic diversification and library screening or selection, has become one of the most useful and widespread...
Effects of 3D microwell culture on initial fate specification in human embryonic stem cells [0.03%]
三维微井培养对人体胚胎干细胞初始命运决定的影响
Cheston Hsiao,Matthew Tomai,Jeremy Glynn et al.
Cheston Hsiao et al.
Several studies have demonstrated that 3D culture systems influence human embryonic stem cell (hESC) phenotypes and fate choices. However, the effect that these microenvironmental changes have on signaling pathways governing hESC behaviors ...
Influence of the Phase State of Self-Assembling Redox Mediators on their Electrochemical Activity [0.03%]
自组装氧化还原介质的相态对其电化学活性的影响
John P E Muller,Burcu S Aytar,Yukishige Kondo et al.
John P E Muller et al.
Self-assembling redox mediators have the potential to be broadly useful in a range of interfacial electrochemical contexts because the oxidation state and state of assembly of the mediator are closely coupled. In this paper, we report an in...
Creation and Evaluation of a Single-chain Antibody Tetramer that Targets Brain Endothelial Cells [0.03%]
一种靶向脑内皮细胞的单链抗体四聚体的构建及鉴定
Xiaobin Zhang,Xin Xiang Wang,Eric V Shusta
Xiaobin Zhang
Antibodies that target and internalize into blood-brain barrier (BBB) endothelial cells offer promise as drug delivery agents. Previously, we identified a single-chain antibody (scFvA) capable of binding to the BBB. In an attempt to improve...
Insulin Release Dynamics from Poly(diethylaminoethyl methacrylate) Hydrogel Systems [0.03%]
聚（二乙基氨基乙基甲基丙烯酸酯）水凝胶系统的胰岛素释放动力学
Steve R Marek,Nicholas A Peppas
Steve R Marek
Novel glucose-sensitive systems for the release of insulin from poly(diethylaminoethyl methacrylate) (PDEAEM) micro-particles and nanoparticles decorated with glucose oxidase and catalase enzymes have been developed. The effect of polymer c...
Design of Gas-phase Synthesis of Core-Shell Particles by Computational Fluid - Aerosol Dynamics [0.03%]
计算流体-气溶胶动力学设计核壳结构颗粒的气相合成方法研究
B Buesser,S E Pratsinis
B Buesser
Core-shell particles preserve the bulk properties (e.g. magnetic, optical) of the core while its surface is modified by a shell material. Continuous aerosol coating of core TiO2 nanoparticles with nanothin silicon dioxide shells by jet inje...
Kevin D Dorfman
Kevin D Dorfman