Evaluation of Nanoparticle Tracking for Characterization of Fibrillar Protein Aggregates [0.03%]
纳米颗粒跟踪分析技术表征纤维状蛋白质聚集体性能的评估
Dennis T Yang,Xiaomeng Lu,Yamin Fan et al.
Dennis T Yang et al.
Amyloidogenesis is the process of formation of protein aggregates with fibrillar morphology. Because amyloidogenesis is linked to neurodegenerative disease, there is interest in understanding the mechanism of fibril growth. Kinetic models o...
Ryan E Cobb,Ran Chao,Huimin Zhao
Ryan E Cobb
Directed evolution, the laboratory process by which biological entities with desired traits are created through iterative rounds of genetic diversification and library screening or selection, has become one of the most useful and widespread...
Effects of 3D microwell culture on initial fate specification in human embryonic stem cells [0.03%]
三维微井培养对人体胚胎干细胞初始命运决定的影响
Cheston Hsiao,Matthew Tomai,Jeremy Glynn et al.
Cheston Hsiao et al.
Several studies have demonstrated that 3D culture systems influence human embryonic stem cell (hESC) phenotypes and fate choices. However, the effect that these microenvironmental changes have on signaling pathways governing hESC behaviors ...
Influence of the Phase State of Self-Assembling Redox Mediators on their Electrochemical Activity [0.03%]
自组装氧化还原介质的相态对其电化学活性的影响
John P E Muller,Burcu S Aytar,Yukishige Kondo et al.
John P E Muller et al.
Self-assembling redox mediators have the potential to be broadly useful in a range of interfacial electrochemical contexts because the oxidation state and state of assembly of the mediator are closely coupled. In this paper, we report an in...
Creation and Evaluation of a Single-chain Antibody Tetramer that Targets Brain Endothelial Cells [0.03%]
一种靶向脑内皮细胞的单链抗体四聚体的构建及鉴定
Xiaobin Zhang,Xin Xiang Wang,Eric V Shusta
Xiaobin Zhang
Antibodies that target and internalize into blood-brain barrier (BBB) endothelial cells offer promise as drug delivery agents. Previously, we identified a single-chain antibody (scFvA) capable of binding to the BBB. In an attempt to improve...
Insulin Release Dynamics from Poly(diethylaminoethyl methacrylate) Hydrogel Systems [0.03%]
聚（二乙基氨基乙基甲基丙烯酸酯）水凝胶系统的胰岛素释放动力学
Steve R Marek,Nicholas A Peppas
Steve R Marek
Novel glucose-sensitive systems for the release of insulin from poly(diethylaminoethyl methacrylate) (PDEAEM) micro-particles and nanoparticles decorated with glucose oxidase and catalase enzymes have been developed. The effect of polymer c...
Design of Gas-phase Synthesis of Core-Shell Particles by Computational Fluid - Aerosol Dynamics [0.03%]
计算流体-气溶胶动力学设计核壳结构颗粒的气相合成方法研究
B Buesser,S E Pratsinis
B Buesser
Core-shell particles preserve the bulk properties (e.g. magnetic, optical) of the core while its surface is modified by a shell material. Continuous aerosol coating of core TiO2 nanoparticles with nanothin silicon dioxide shells by jet inje...
Kevin D Dorfman
Kevin D Dorfman
Thermoresponsive Platforms for Tissue Engineering and Regenerative Medicine [0.03%]
温敏平台在组织工程与再生医学中的应用
Halil Tekin,Jefferson G Sanchez,Tonia Tsinman et al.
Halil Tekin et al.
ASTRO-FOLD 2.0: an Enhanced Framework for Protein Structure Prediction [0.03%]
ASTRO-FOLD 2.0：一种增强的蛋白质结构预测框架
A Subramani,Y Wei,C A Floudas
A Subramani
The three-dimensional (3-D) structure prediction of proteins, given their amino acid sequence, is addressed using the first principles-based approach ASTRO-FOLD 2.0. The key features presented are: (1) Secondary structure prediction using a...