Rapid microsphere-assisted peptide screening (MAPS) of promiscuous MHCII-binding peptides in Zika virus envelope protein [0.03%]
快速的用于寨卡病毒包膜蛋白泛MHCII结合肽筛选的微球辅助肽谱技术(MAPS)
Mason R Smith,Luke F Bugada,Fei Wen
Mason R Smith
Despite promising developments in computational tools, peptide-class II MHC (MHCII) binding predictors continue to lag behind their peptide-class I MHC counterparts. Consequently, peptide-MHCII binding is often evaluated experimentally usin...
Vapor- and Liquid-Phase Adsorption of Alcohol and Water in Silicalite-1 Synthesized in Fluoride Media [0.03%]
氟介质中合成的丝光沸石中酒精和水的气相和液相吸附性能研究
Robert F DeJaco,Matheus Dorneles de Mello,Huong Giang T Nguyen et al.
Robert F DeJaco et al.
In this work, batch-adsorption experiments and molecular simulations are employed to probe the adsorption of binary mixtures containing ethanol or a linear alkane-1,n-diol solvated in water or ethanol onto silicate-1. Since the batch-adsorp...
A data-driven optimization algorithm for differential algebraic equations with numerical infeasibilities [0.03%]
具有数值不可行性的代数微分方程的数据驱动优化算法
Burcu Beykal,Melis Onel,Onur Onel et al.
Burcu Beykal et al.
Support Vector Machines (SVMs) based optimization framework is presented for the data-driven optimization of numerically infeasible Differential Algebraic Equations (DAEs) without the full discretization of the underlying first-principles m...
Bridging 2D and 3D culture: probing impact of extracellular environment on fibroblast activation in layered hydrogels [0.03%]
从2D到3D培养：探究分层水凝胶中外源环境对成纤维细胞激活的影响
Megan E Smithmyer,Samantha E Cassel,April M Kloxin
Megan E Smithmyer
Many cell behaviors are significantly affected by cell culture geometry, though it remains unclear which geometry from two- to three-dimensional (2D to 3D) culture is appropriate for probing a specific cell function and mimicking native mic...
Directed evolution methods for overcoming trade-offs between protein activity and stability [0.03%]
用于克服蛋白质活性与稳定性之间权衡的定向进化方法
Samuel D Stimple,Matthew D Smith,Peter M Tessier
Samuel D Stimple
Engineered proteins are being widely developed and employed in applications ranging from enzyme catalysts to therapeutic antibodies. Directed evolution, an iterative experimental process composed of mutagenesis and library screening, is a p...
A Nonlinear Support Vector Machine-Based Feature Selection Approach for Fault Detection and Diagnosis: Application to the Tennessee Eastman Process [0.03%]
基于非线性支持向量机的特征选择方法在故障检测和诊断中的应用：东 TENNESSEE 工艺过程应用研究
Melis Onel,Chris A Kieslich,Efstratios N Pistikopoulos
Melis Onel
In this article, we present (1) a feature selection algorithm based on nonlinear support vector machine (SVM) for fault detection and diagnosis in continuous processes and (2) results for the Tennessee Eastman benchmark process. The present...
Jiwon Lee,Bryan S Der,Christos S Karamitros et al.
Jiwon Lee et al.
We used the molecular modeling program Rosetta to identify clusters of amino acid substitutions in antibody fragments (scFvs and scAbs) that improve global protein stability and resistance to thermal deactivation. Using this methodology, we...
Identification of the Pyranonigrin A Biosynthetic Gene Cluster by Genome Mining in Penicillium thymicola IBT 5891 [0.03%]
从Penicillium thymicola IBT 5891菌株中挖掘获得吡喃黑霉素A生物合成基因簇
Man-Cheng Tang,Yi Zou,Danielle Yee et al.
Man-Cheng Tang et al.
The Effect of Divalent Cations on the Thermostability of Type II Polyketide Synthase Acyl Carrier Proteins [0.03%]
二价阳离子对II型聚酮合酶乙酰载体蛋白热稳定性的效果研究
Marco Rivas,Valentine C Courouble,Miranda C Baker et al.
Marco Rivas et al.
The successful engineering of biosynthetic pathways hinges on understanding the factors that influence acyl carrier protein (ACP) stability and function. The stability and structure of ACPs can be influenced by the presence of divalent cati...
Multi-Model Sensor Fault Detection and Data Reconciliation: A Case Study with Glucose Concentration Sensors for Diabetes [0.03%]
多模型传感器故障检测与数据校正：以糖尿病血糖浓度传感器为例的研究
Jianyuan Feng,Iman Hajizadeh,Xia Yu et al.
Jianyuan Feng et al.
Erroneous information from sensors affect process monitoring and control. An algorithm with multiple model identification methods will improve the sensitivity and accuracy of sensor fault detection and data reconciliation (SFD&DR). A novel ...