Techno-economic analysis of dynamic, end-to-end optimal pharmaceutical campaign manufacturing using PharmaPy [0.03%]
使用PharmaPy进行动态端到端最优制药工艺制造的技术经济分析
Daniel Casas-Orozco,Daniel Laky,Vivian Wang et al.
Daniel Casas-Orozco et al.
Increased interest in the pharmaceutical industry to transition from batch to continuouos manufacturing motivates the use of digital frameworks that allow systematic comparison of candidate process configurations. This paper evaluates the t...
Sachit G Nagella,Sho C Takatori
Sachit G Nagella
We study the transport phenomena of colloidal particles embedded within a moving array of obstacles that mimics a dynamic, time-varying porous material. While colloidal transport in an array of stationary obstacles ("passive" porous media) ...
Closed-loop modeling of central and intrinsic cardiac nervous system circuits underlying cardiovascular control [0.03%]
心血管控制的中心和固有心脏神经系统的闭环建模
Michelle M Gee,Abraham M Lenhoff,James S Schwaber et al.
Michelle M Gee et al.
The baroreflex is a multi-input, multi-output control physiological system that regulates blood pressure by modulating nerve activity between the brainstem and the heart. Existing computational models of the baroreflex do not explictly inco...
Modeling Heterogeneous Bacterial Populations Exposed to Antibiotics: The Logistic-Dynamics Case [0.03%]
暴露于抗生素的异质性细菌群体的建模：逻辑动态模型案例
Pratik R Bhagunde,Michael Nikolaou,Vincent H Tam
Pratik R Bhagunde
In typical in vitro tests for clinical use or development of antibiotics, samples from a bacterial population are exposed to an antibiotic at various concentrations. The resulting data can then be used to build a mathematical model suitable...
Electrified methane steam reforming on a washcoated SiSiC foam for low-carbon hydrogen production [0.03%]
等离子体促进甲烷蒸汽重整制氢研究
Lei Zheng,Matteo Ambrosetti,Daniele Marangoni et al.
Lei Zheng et al.
In view of largely available renewable electricity as a green future resource, here we report the electrification of a Rh/Al2O3 washcoated SiSiC foam for methane steam reforming (MSR). We show that, thanks to the suitable bulk resistivity o...
Flow physics of planar bistable fluidic oscillator with backflow limbs [0.03%]
具有回流臂的平面双稳态流体振子的流动物理现象
Ketan Madane,Chirag Khalde,Ajinkya Pandit et al.
Ketan Madane et al.
Fluidic oscillators (FOs) are used in a variety of applications, including process control and process intensification. Despite the simple design and operation of FOs, the fluid dynamics of FOs exhibit rich complexities. The inherently unst...
Seren Hamsici,Gokhan Gunay,Handan Acar
Seren Hamsici
Aggregation of otherwise soluble proteins into amyloid structures is a hallmark of many disorders, such as Alzheimer's and Parkinson's disease. There is an increasing evidence that the small aggregations, instead of ordered fibrillar aggreg...
Unraveling the biosynthesis of penicillenols by genome mining PKS-NRPS gene clusters in Penicillium citrinum [0.03%]
通过基因组挖掘来解析黄青霉中Penicillenol的生物合成通路
Qiuyue Nie,Shuqi Guo,Xue Gao
Qiuyue Nie
Penicillenols belong to the family of tetramic acids with anticancer and antibacterial activities. Here, we report the discovery of the biosynthetic gene cluster (pnc) for penicillenol A1 and E in Penicillium citrinum ATCC9849 by genome min...
Multiple insights call for revision of modern thermodynamic models to account for structural fluctuations in water [0.03%]
多重见解呼吁修订现代热力学模型以解释水中的结构波动
Evangelos Tsochantaris,Aswin V Muthachikavil,Baoliang Peng et al.
Evangelos Tsochantaris et al.
Modern thermodynamic models incorporate the concept of association (hydrogen bonding) and they can describe very satisfactorily many properties of water containing mixtures. They have not been successful in representing water's anomalous pr...
Surfactant Interactions and Solvent Phase Solubility Modulate Small Molecule Release from Emulsion Electrospun Fibers [0.03%]
表面活性剂相互作用和溶剂相溶解度调节乳液电纺纤维中的小分子释放
Pamela M Johnson,Justin M Lehtinen,Jennifer L Robinson
Pamela M Johnson
Emulsion electrospinning provides a tunable system for the development of porous scaffolds for controlled, localized drug delivery in tissue engineering applications. This study aimed to elucidate the role of model drug interactions with em...