Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation [0.03%]
PYROXD1介导的人tRNA连接酶复合物抵抗氧化失活的机制基础
Luuk Loeff,Alena Kroupova,Igor Asanović et al.
Luuk Loeff et al.
The metazoan tRNA ligase complex (tRNA-LC) has essential roles in tRNA biogenesis and unfolded protein response. Its catalytic subunit RTCB contains a conserved active-site cysteine that is susceptible to metal ion-induced oxidative inactiv...
RTP801 interacts with the tRNA ligase complex and dysregulates its RNA ligase activity in Alzheimer's disease [0.03%]
RTP801与tRNA连接酶复合物相互作用并调节其RNA连接酶活性从而促进阿尔茨海默病发生发展
Genís Campoy-Campos,Julia Solana-Balaguer,Anna Guisado-Corcoll et al.
Genís Campoy-Campos et al.
RTP801/REDD1 is a stress-responsive protein overexpressed in neurodegenerative diseases such as Alzheimer's disease (AD) that contributes to cognitive deficits and neuroinflammation. Here, we found that RTP801 interacts with HSPC117, DDX1 a...
Thioredoxin regulates the redox state and the activity of the human tRNA ligase complex [0.03%]
硫氧还蛋白通过调节氧化还原状态和活性来调控人tRNA连接酶复合体
Dhaarsini Jaksch,Johanna Irnstorfer,Petra-Franziska Kalman et al.
Dhaarsini Jaksch et al.
The mammalian tRNA ligase complex (tRNA-LC) catalyzes the splicing of intron-containing pre-tRNAs in the nucleus and the splicing of XBP1 mRNA during the unfolded protein response (UPR) in the cytoplasm. We recently reported that the tRNA-L...
Alena Kroupova,Fabian Ackle,Igor Asanović et al.
Alena Kroupova et al.
RtcB enzymes are RNA ligases that play essential roles in tRNA splicing, unfolded protein response, and RNA repair. In metazoa, RtcB functions as part of a five-subunit tRNA ligase complex (tRNA-LC) along with Ddx1, Cgi-99, Fam98B, and Ashw...
The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells [0.03%]
哺乳动物tRNA连接酶复合物介导XBP1mRNA剪接并调控浆细胞中抗体的分泌
Jennifer Jurkin,Theresa Henkel,Anne Færch Nielsen et al.
Jennifer Jurkin et al.
The unfolded protein response (UPR) is a conserved stress-signaling pathway activated after accumulation of unfolded proteins within the endoplasmic reticulum (ER). Active UPR signaling leads to unconventional, enzymatic splicing of XBP1 mR...