Inactivation of RhoA for Hypertension Treatment Through the TRPV4-RhoA-RhoGDI1 Axis [0.03%]
TRPV4-RhoA-RhoGDI1轴灭活RhoA以治疗高血压
Jiawen Wang,Zhen Yuan,Na Yu et al.
Jiawen Wang et al.
This inhibition notably decreased both acute and long-term blood pressure and prevented vascular remodeling in Ang II-induced hypertensive mice and spontaneously hypertensive rats. However, these antihypertensive effects were weakened in Trpv4-/- and Arhgdiaf/f Myh11-CREERT2 mice.
Activated Factor X Inhibition Ameliorates NF-κB-IL-6‒Mediated Perivascular Inflammation and Pulmonary Hypertension [0.03%]
活化因子X抑制改善NF-κB-IL-6介导的血管周围炎症和肺动脉高压
Satomi Imakiire,Keiji Kimuro,Keimei Yoshida et al.
Satomi Imakiire et al.
Methods and results: The effects of edoxaban, a selective FXa inhibitor, on hemodynamic, right ventricular (RV) hypertrophy, and vascular remodeling were evaluated in a monocrotaline (MCT)-exposed PH rat model....Daily administration of edoxaban (10 mg/kg/day, by gavage) starting from the day of MCT injection for 21 days ameliorated RVSP, TPRI, RV hypertrophy, pulmonary vascular remodeling and macrophage accumulation....Conclusions: Inhibition of FXa ameliorates NF-κB-IL-6‒mediated perivascular inflammation, pulmonary vascular remodeling and the development of PH in MCT-exposed rats, suggesting that FXa may be a potential target for the treatment of PAH.
Fucoxanthin Ameliorates Vascular Remodeling via Attenuating Oxidative Stress in Hypoxic Pulmonary Hypertension Rats [0.03%]
岩藻黄素通过减轻缺氧性肺动脉高压大鼠氧化应激来改善血管重塑
Xu Zheng,Jina Zhao,Xiaoqin Jia et al.
Xu Zheng et al.
Hypoxic pulmonary hypertension (HPH) is a fatal cardiopulmonary disease characterized by pulmonary vascular remodeling, primarily resulting from abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs). Fucoxanthin, a natural...
Modeling the coupling between stent degradation and vascular remodeling considering the effects of mechanical stimuli and geometric interaction [0.03%]
考虑机械刺激和几何相互作用影响的血管重塑与支架降解耦合建模研究
Hanbing Zhang,Shiliang Chen,Tianming Du et al.
Hanbing Zhang et al.
Background and objectives: The degradation of stents and vascular remodeling are processes involving mechanical and geometric interactions. However, in previous studies, these two processes were treated as independent....Methods: A stent degradation model that incorporates multiple corrosion factors and a vascular remodeling model that considers artery stress stimuli were first established....Based on this coupling model, we simulated stent degradation and vascular remodeling under different mechanical and geometric interaction conditions.
Molecular mechanisms and intervention approaches of heart failure (Review) [0.03%]
心力衰竭的分子机制及干预策略（综述）
Shuang Guo,Yingqing Hu,Li Ling et al.
Shuang Guo et al.
The pathological mechanisms through which cardiovascular diseases result in heart failure include myocardial fibrosis and hypertrophy, myocardial cell death, mitochondrial dysfunction, vascular remodeling and calcium dysregulation.
Reversal of cerebrovascular anomalies in a zebrafish model of vein of Galen aneurysm [0.03%]
斑马鱼静脉导管动脉瘤模型中脑血管异常的逆转
Edwige Martin-Valiente,Yao Du,Chloé Goemans et al.
Edwige Martin-Valiente et al.
By pharmacologically targeting these signaling pathways in mutant models, we restore normal fusion in existing malformations, offering potential new strategies for treating VGAMs and similar vascular remodeling disorders.
RNF213 and cardiovascular disease: a review of histopathological, genetic perspectives, and potential molecular mechanisms [0.03%]
RNF213与心血管病：病理、遗传及分子机制综述研究进展
Toshinaru Kawakami,Masamichi Ito,Takayuki Isagawa et al.
Toshinaru Kawakami et al.
Its mutation disrupts normal angiogenesis, contributing to abnormal vascular remodeling in conditions such as pulmonary hypertension and coronary artery disease.
Zinc-mediated Inhibition of Soluble Epoxide Hydrolase Promotes Pulmonary Hypertension [0.03%]
锌介导的可溶性表环氧合酶抑制剂促进肺高血压
Daniel Simoes de Jesus,Stanley Buffonge,Giancarlo Abis et al.
Daniel Simoes de Jesus et al.
Rationale: Pulmonary hypertension (PH) and vascular remodeling involve complex molecular mechanisms, with zinc and epoxyeicosatrienoic acids playing key roles....Objectives: To investigate whether zinc-mediated inhibition of soluble epoxide hydrolase contributes to the development of PH and vascular remodeling under hypoxic conditions.
Lats1/2 Are Essential for Developmental Vascular Remodeling and Biomechanical Adaptation to Shear Stress [0.03%]
Lats1/2在发育血管重塑和适应剪切应力的生物力学适应中必不可少
Mitzy A Cowdin,Tuli Pramanik,Shelby R Mohr-Allen et al.
Mitzy A Cowdin et al.
Background: Mechanical cues exerted by shear stress from blood flow remodel an initial vascular plexus into a ramifying array of large and small vessels. Hemodynamic forces trigger changes in endothelial cell (EC) gene ex...
Transmembrane Protein-184A Interacts with Syndecan-4 and Rab GTPases and Is Required to Maintain VE-Cadherin Levels [0.03%]
跨膜蛋白184A与硫酸肝素蛋白多糖4和Rab GTP酶相互作用，对于维持血管内皮细胞钙黏着蛋白的水平是必需的
Leanna M Altenburg,Stephanie H Wang,Grace O Ciabattoni et al.
Leanna M Altenburg et al.
VE-cadherin (VE-cad) membrane stability and localization regulates adhesion formation and actin cytoskeleton dynamics in angiogenesis and vascular remodeling and requires the heparan sulfate proteoglycan (HSPG), Syndecan-4 (Sdc4).
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