Associations between radiocurability and interstitial fluid pressure in human tumor xenografts without hypoxic tissue [0.03%]
乏氧组织的人肿瘤异种移植瘤中放射治愈率与间质液压力之间的关系
Einar K Rofstad,Else-Beate M Ruud,Berit Mathiesen et al.
Einar K Rofstad et al.
The aim of this preclinical study was to investigate whether tumor radiocurability may be associated with IFP through hypoxia-independent mechanisms.
Radiocurability is associated with interstitial fluid pressure in human tumor xenografts [0.03%]
放射治疗敏感性与人源肿瘤异种移植模型的间质压力有关关系
Einar K Rofstad,Jon-Vidar Gaustad,Kjetil G Brurberg et al.
Einar K Rofstad et al.
The main aims of this study were to investigate whether tumor radiocurability may be associated with IFP and, if so, to identify possible mechanisms. Human melanoma xenografts transplanted intradermally or in window chamber preparations in BALB/c nu/nu mice were used as preclinical tumor models....Therefore, the observed association between tumor radiocurability and IFP was most likely an indirect consequence of a strong relationship between IFP and the fraction of acutely hypoxic cells.
130-nm albumin-bound paclitaxel enhances tumor radiocurability and therapeutic gain [0.03%]
130nm白蛋白结合紫杉醇可增强肿瘤放疗敏感度及治疗获益
Nicole Wiedenmann,David Valdecanas,Nancy Hunter et al.
Nicole Wiedenmann et al.
Purpose: 130-nm albumin-bound paclitaxel (nab-paclitaxel) is a novel solvent-free albumin-bound paclitaxel, designed to avoid solvent-related toxicity. Nab-paclitaxel has been successfully introduced into the clinic but i...
Epidermal growth factor receptor and tumor response to radiation: in vivo preclinical studies [0.03%]
表皮生长因子受体与肿瘤放疗反应的体内实验研究
Luka Milas,Zhen Fan,Nicolaus H Andratschke et al.
Luka Milas et al.
Results: Our studies showed that high levels of EGFR were associated with decreased tumor radiocurability of murine carcinomas. The causal role of EGFR in mediating cellular resistance to RT was demonstrated by transfecting the EGFR cDNA into the cells with low levels of EGFR.
Electroporation of LPB sarcoma cells in vitro and tumors in vivo increases the radiosensitizing effect of cisplatin [0.03%]
体外和体内电穿孔递送的顺铂增敏LPB肉瘤细胞和肿瘤放射治疗效应
Simona Kranjc,Maja Cemazar,Alenka Grosel et al.
Simona Kranjc et al.
Also, the tumor radiocurability of this combined treatment was significantly enhanced, compared to irradiated tumors (enhancement factor; EF = 1.6) and to tumors treated with cisplatin and irradiation (EF = 1.4).
Poly(L-glutamic acid)-paclitaxel conjugate is a potent enhancer of tumor radiocurability [0.03%]
聚L-谷氨酸-紫杉醇共聚物可增强肿瘤放疗效果
Luka Milas,Kathryn A Mason,Nancy Hunter et al.
Luka Milas et al.
Conclusion: PG-TXL dramatically potentiated tumor radiocurability after single-dose or fractionated irradiation without affecting acute normal tissue injury.
C225 antiepidermal growth factor receptor antibody enhances tumor radiocurability [0.03%]
抗表皮生长因子受体抗体C225增敏肿瘤放射治疗作用研究
S Nasu,K K Ang,Z Fan et al.
S Nasu et al.
Conclusion: The data presented here demonstrate that C225 can increase tumor radiocurability and delay the appearance of recurrences of tumors not cured by radiation treatment.
L Milas,T Fujii,N Hunter et al.
L Milas et al.
Although gemcitabine reduced the radiation tumor control dose at all administration times used, the greatest enhancement of tumor radiocurability occurred when gemcitabine was administered 24 h before irradiation (dose modification factor of 1.54).
Repair of potentially lethal X ray damage and possible applications to clinical radiotherapy [0.03%]
修复潜在致死性X射线损伤及可能的临床放射治疗应用
R R Weichselbaum,J B Little
R R Weichselbaum
We also have examined how the repair of potentially lethal damage may alter the therapeutic ratio by altering tumor radiocurability and normal tissue tolerance.
Predicting radiocurability [0.03%]
预测放射敏感性
L J Peters,W Brock,T Johnson
L J Peters
Several predictors of tumor radiocurability are already integrated into clinical practice, e.g., tumor size, gross morphologic features (i.e., infiltrative or exophytic), histologic type, and grade. These are relatively imprecise, however, and none is specific.
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