Véronique A Dartois,Valerie Mizrahi,Radojka M Savic et al.
Véronique A Dartois et al.
In the absence of effective patient-stratification approaches, tuberculosis (TB) treatment relies on overtreating most patients to ensure high cure rates. Shortening treatment duration without compromising efficacy is therefore high on the ...
Second-Line Anti-Tuberculosis Therapy in MDR-TB Children: Time to Move Beyond One-Size-Fits-All! [0.03%]
儿童耐多药结核病二线治疗：是时候超越“一刀切”疗法了！
Kalyana Prabhakaran,Jagdish Prasad Goyal
Kalyana Prabhakaran
Exploring factors influencing the health-related quality of life of tuberculosis patients: a WHOQOL-BREF-based study [0.03%]
基于WHOQOL-BREF的结核病患者生命质量影响因素研究
Surabhi Panduranga Kodical,Rishabh Roy,Deekshitha Shetty et al.
Surabhi Panduranga Kodical et al.
The current study was conducted to assess the quality of life of patients receiving tuberculosis therapy and to identify the associated risk factors.
Mannosamine-Modified Poly(lactic- co-glycolic acid)-Polyethylene Glycol Nanoparticles for the Targeted Delivery of Rifapentine and Isoniazid in Tuberculosis Therapy [0.03%]
甘露胺修饰的聚乳酸-co-乙交酯-聚乙二醇纳米颗粒用于结核病治疗中利福平和异烟肼的靶向递送
Cong Peng,Haopeng Luan,Qisong Shang et al.
Cong Peng et al.
Tuberculosis, caused by Mycobacterium tuberculosis, is the leading cause of mortality attributed to a single infectious agent. Following macrophage invasion, M. tuberculosis uses various mechanisms to evade immune responses and to resist an...
Design, Fabrication, and In Vitro - In Vivo Evaluation of Surface-Engineered Pyrazinamide-Loaded Lipid Nanoparticles for Tuberculosis Therapy [0.03%]
一种用于结核病治疗的载有异烟肼的表面工程脂质纳米粒的设计、制备及体内外评价研究
Nimitt V Chokshi,Preksha Vinchhi,Shreyansh Chauhan et al.
Nimitt V Chokshi et al.
Pyrazinamide (PYZ), a nicotinamide derivative, is an essential first-line anti-TB drug. However, its dose-dependent hepatotoxicity poses a considerable challenge, accentuating the need for improved delivery approaches. The key objective of ...
Exploring spirocyclic isoquinoline-piperidine compounds in tuberculosis therapy: ADMET profiling, docking, DFT, MD simulations, and MMGBSA analysis [0.03%]
用于结核病治疗的螺环异喹啉-哌啶化合物的研究：ADMET分析、对接、DFT、MD模拟和MMGBSA分析
Sri Mounika Bellapukonda,Siva Singothu,Anuradha Singampalli et al.
Sri Mounika Bellapukonda et al.
Tuberculosis remains a global health challenge due to drug-resistant strains. MmpL3 inhibitors have emerged as promising anti-tubercular agents, and their clinical development has been hindered by poor microsomal stability. This study compu...
An unexpected case of hypothyroidism in a young female patient undergoing first-line anti-tuberculosis therapy for pulmonary tuberculosis [0.03%]
肺结核抗结核一线治疗中年轻女性患者甲状腺功能减退一例报告
Haroon Ahmed Khan,Uooja Devi,Muhammad Faheem Iqbal et al.
Haroon Ahmed Khan et al.
Hypothyroidism, once considered a rare adverse effect of anti-tuberculosis (TB) medication, is increasingly observed in patients undergoing second-line therapy for multidrug-resistant tuberculosis (MDR-TB). This study discusses a case invol...
Recent Advances in Inhibitor Development and Metabolic Targeting in Tuberculosis Therapy [0.03%]
结核病治疗中抑制剂开发及代谢靶向的近期进展
Ritu Raj Patel,Vidyasagar,Sudhir Kumar Singh et al.
Ritu Raj Patel et al.
Despite being a preventable and treatable disease, tuberculosis (TB) remained the second leading infectious cause of death globally in 2022, surpassed only by COVID-19. The death rate from TB is influenced by numerous factors that include a...
Mycobacterium tuberculosis FtsB and PerM interact via a C-terminal helix in FtsB to modulate cell division [0.03%]
结核分枝杆菌的FtsB和PerM通过FtsB末端的螺旋结构相互作用来调节细胞分裂
João Ramalheira Ferreira,Ruilan Xu,Zach Hensel
João Ramalheira Ferreira
Latent infection by Mycobacterium tuberculosis (Mtb) impedes effective tuberculosis therapy and eradication. The protein PerM is essential for chronic Mtb infections in mice and acts via the divisome protein FtsB to modulate cell division.
Primary cutaneous mixed infection with Cryptococcus uniguttulatus and Mycobacterium tuberculosis [0.03%]
原发皮肤隐球菌和结核分枝杆菌混合感染一例
Yakun Shao,Yinggai Song,Ruoning Xue et al.
Yakun Shao et al.
Following successful management of the cryptococcal infection, combination anti-M. tuberculosis therapy led to significant improvement of the cutaneous lesions.
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