Structure, function and catalytic mechanism of the carrageenan-sulfatases from the marine bacterium Zobellia galactanivorans DsijT [0.03%]
来源于海洋细菌Zobellia galactanivorans DsijT的琼脂糖硫酸化酶结构、功能及催化机制研究
Antonin Chevenier,Mathieu Fanuel,Ekaterina Sokolova et al.
Antonin Chevenier et al.
High resolution structures of the S1_19 endo-/exo-lytic carrageenan sulfatase (ZgCgsA) in complex with oligocarrageenan products show substrate plasticity which involve enzyme and glycan conformational rearrangements.
Preparation, assay, and application of 4-fluorothreonine transaldolase from Streptomyces sp. MA37 for β-hydroxyl amino acid derivatives [0.03%]
来自动细菌MA37的4-氟苏糖酸转酮酶的制备、纯化及在β-羟基氨基酸衍生物中的应用研究
Fleurdeliz Maglangit,Hai Deng
Fleurdeliz Maglangit
It has been demonstrated that FTaseMA displays considerable substrate plasticity toward structurally diverse aldehyde acceptors, leading to the production of various βHAAs.
Identification of the mechanism for dehalorespiration of monofluoroacetate in the phylum Synergistota [0.03%]
Synergistota门中单氟乙酸脱卤呼吸作用机制的识别
Lex E X Leong,Stuart E Denman,Seungha Kang et al.
Lex E X Leong et al.
Conclusion: Identification of this unusual anaerobic fluoroacetate metabolism extends the known substrates for dehalorespiration and indicates the potential for substrate plasticity in amino acid-reducing enzymes to include xenobiotics.
Substrate Plasticity Enables Group-Selective Transmetalation: Catalytic Stereospecific Cross-Couplings of Tertiary Boronic Esters [0.03%]
底物的塑形性实现组特异性转金属化：叔硼酸酯的催化立体选择性交叉偶联反应
Hao Liang,James P Morken
Hao Liang
Activation of enantiomerically enriched tertiary alkylboronic esters with adamantyllithium generated in situ enables stereoretentive boron-to-copper transmetalation. The resulting alkylcopper species can undergo cross-coupling reactions wit...
Substrate plasticity of dehydratase SpaKC from the biosynthesis of thiosparsoamide [0.03%]
来自thiosparsoamide生物合成的去 hydrated酶SpaKC的底物塑料性
Ciji Wang,Jingxia Lu,Yingying Zhang et al.
Ciji Wang et al.
Thioamitides are a group of ribosomally synthesized and post-translationally modified peptides that possess diverse bioactivities and are usually featured by thioamide and 2-aminovinyl-cysteine (AviCys) motifs. In natural product thiosparso...
Haigang Song,Ju Ratè Fahrig-Kamarauskaitè,Emmanuel Matabaro et al.
Haigang Song et al.
The methylation of amide nitrogen atoms can improve the stability, oral availability, and cell permeability of peptide therapeutics. Chemical N-methylation of peptides is challenging. Omphalotin A is a ribosomally synthesized, macrocylic do...
An unusual metal-bound 4-fluorothreonine transaldolase from Streptomyces sp. MA37 catalyses promiscuous transaldol reactions [0.03%]
一株链霉菌来源的非常规金属结合型4-氟苏糖酸转酮酶催化多种底物的转酮反应
Linrui Wu,Ming Him Tong,Andrea Raab et al.
Linrui Wu et al.
FTaseMA displays considerable substrate plasticity to generate 4-FT as well as other β-hydroxy-α-amino acids with various functionalities at C4 position, giving the prospect of new chemo-enzymatic applications.
New insights into transport capability of sugars and its impact on growth from novel mutants of Escherichia coli [0.03%]
新型大肠杆菌突变体为糖的运输能力及其对生长的影响提供了新见解
Alma Alva,Andrea Sabido-Ramos,Adelfo Escalante et al.
Alma Alva et al.
Elucidation of the molecular and biochemical basis of sugar-transport substrate plasticity represents a consistent approach for sugar-transport system engineering for the design of efficient E. coli derivative strains with improved substrate assimilation for biotechnological purposes.
Investigation of Penicillin Binding Protein (PBP)-like Peptide Cyclase and Hydrolase in Surugamide Non-ribosomal Peptide Biosynthesis [0.03%]
丝状霉素非核糖体肽生物合成中的青霉酰多肽酶和肽环化酶及水解酶的初步研究
Yongjun Zhou,Xiao Lin,Chunmin Xu et al.
Yongjun Zhou et al.
SurE also displays considerable substrate plasticity with expanded ring or different amino acid compositions to produce different cyclopeptides, highlighting the potential of chemoenzymatic applications. Site-directed mutagenesis allowed identification of the key residues of SurE.
Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis [0.03%]
钯介导的酶活化表明糖原生成存在多相启动现象
Matthew K Bilyard,Henry J Bailey,Lluís Raich et al.
Matthew K Bilyard et al.
Careful mimicry of GYG intermediates recapitulates catalytic activity at distinct stages, which in turn allows discovery of triphasic kinetics and substrate plasticity in GYG's use of sugar substrates.
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