SERCA2 gatekeeper role in aortic autophagy: targeting the Ca2+-mTOR axis to prevent aortic dissection [0.03%]
SERCA2在主动脉自噬中的门控作用：靶向Ca2+-mTOR轴以预防主动脉夹层
Lang-Tao Wang,Xun Chen,Jia-Rou Song et al.
Lang-Tao Wang et al.
We previously identified oxidative inactivation of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2 (SERCA2) at cysteine 674 (C674) as a driver of aortic smooth muscle cell (ASMC) phenotypic switching. However, its causal impact on autophagic flux and AD remains unresolved.
Fatty acid decarboxylases for sustainable linear α-olefin production: mechanisms, engineering strategies, and applications [0.03%]
脂肪酸脱羧酶在可持续生产线性α烯烃中的作用：机制、工程策略及应用
Mingyu Chen,Yupeng Wan,Mo Xian et al.
Mingyu Chen et al.
OleT is the best-resolved platform and can operate with hydrogen peroxide or with oxygen coupled to either redox proteins and NAD(P)H or small-molecule reductants, but competing decarboxylation, hydroxylation, and oxidative inactivation constrain yield.
Inactivation of SERCA2 at Cys674 induces skeletal muscle atrophy by activating the TGFβ/Smad-S100a4 axis to promote inflammation [0.03%]
Cys674位点SERCA2失活通过激活TGFβ / Smad-S100a4轴促进炎症而引起骨骼肌萎缩
Fei Nan,Siyao Liu,Shunyi Lei et al.
Fei Nan et al.
Conclusions: The oxidative inactivation of the SERCA2 C674 site constitutes a novel mechanism driving skeletal muscle atrophy.
Comprehensive characterisation of IAA inactivation pathways reveals the impact of glycosylation on auxin metabolism and plant development in Arabidopsis [0.03%]
IAA失活途径的全面表征揭示了糖基化对拟南芥生长素代谢和植物发育的影响
Rubén Casanova-Sáez,Aleš Pěnčík,Federica Brunoni et al.
Rubén Casanova-Sáez et al.
DIOXYGENASE FOR AUXIN OXIDATION1 (DAO1) and DAO2, 2-oxoglutarate and iron-dependent dioxygenases, contribute to IAA oxidative inactivation with group II GRETCHEN HAGEN3 (GH3) IAA-amido synthetases, while UDP-glycosyltransferases (UGTs) conjugate IAA to sugars.
Conformational Expansion Underlies the Evolutionary Emergence of Redox Sensitivity in Vertebrate Glucokinases [0.03%]
四膜虫核糖体的低温电子显微镜结构及其与人类80S核糖体的比较
Johanna E Papa,A Carl Whittington,Brian G Miller
Johanna E Papa
To understand the molecular and evolutionary origins of redox regulation, we characterized the sensitivity to oxidative inactivation of four extant GCKs and five ancestral GCKs produced from a recent phylogenetic analysis of the vertebrate family....We find that two invertebrate GCKs are significantly less sensitive to oxidative inactivation compared to their vertebrate counterparts.
The vacuolar tauopathy-associated mutation D395G confers redox sensitivity to p97/VCP [0.03%]
tau相关变异D395G使p97/VCP具有氧化敏感性
Smruti R Rout,Martin Kulke,Maxim A Droemer et al.
Smruti R Rout et al.
We further demonstrate that the D395G mutation sensitizes p97 to oxidative stress by enhancing C522 oxidation, thereby perturbing nucleotide binding in D2, and define the functional basis of this oxidative inactivation of p97.
Immobilization and electrochemical activation synergistically enhance activity, stability and solvent tolerance of an unspecific peroxygenase [0.03%]
固定化和电化学活化协同增强非特异性过氧化物酶的活性、稳定性和溶剂耐受性
Ulises A Zitare,Nahir A Schvarztman,Margarita Seeger et al.
Ulises A Zitare et al.
Unspecific peroxygenases (UPOs) are promising biocatalysts for selective oxyfunctionalization but are limited by low stability and oxidative inactivation by H2O2.
Papaver S-determinants trigger mitochondrially derived ROS production and disrupt energy metabolism in incompatible pollen tubes [0.03%]
神經酸觸發不親和花粉管中由線粒體衍生的ROS產生並破壞能量代謝
Ludi Wang,An-Shan Hsiao,José Carli et al.
Ludi Wang et al.
In parallel, oxidative inactivation of GAPDH inhibits glycolysis, resulting in decreased TCA cycle intermediates and providing a feedback loop to enhance mitochondrial disruption.
Small heat shock protein HSPB5 uses disorder to bind zinc with high affinity [0.03%]
小热休克蛋白HSPB5通过固有无序性结合锌离子
Maria K Janowska,Vanesa Racigh,Christoper N Woods et al.
Maria K Janowska et al.
Metallothioneins buffer zinc under basal conditions, but their re-synthesis following oxidative inactivation occurs on the timescale of hours, raising the question of how free zinc is managed in the interim.
Small heat shock protein HSPB5 uses disorder to bind zinc with high affinity [0.03%]
小热休克蛋白HSPB5通过固有无序结构结合锌离子
Maria K Janowska,Vanesa Racigh,Christoper N Woods et al.
Maria K Janowska et al.
Metallothioneins buffer zinc under basal conditions, but their re-synthesis following oxidative inactivation occurs on the scale of hours, raising the question of how free zinc is managed in the interim.
耗时 0.15936 秒，为您在
50274012
条记录里面共找到 582 篇文章 [XML]