The Redox Paradox: Cancer's Double-Edged Sword for Malignancy and Therapy [0.03%]
氧化还原悖论：癌症促进恶性进展和治疗的双刃剑
Jyotsna Suresh Ranbhise,Manish Kumar Singh,Songhyun Ju et al.
Jyotsna Suresh Ranbhise et al.
These defenses maintain redox homeostasis and sustain oncogenic signaling, notably through the oxidative inactivation of tumor-suppressor phosphatases, such as PTEN, which drives the PI3K/AKT/mTOR pathway.
Dual-pathway inhibition of antibiotic resistance genes by ferrate (Fe(VI)): Oxidative inactivation and genetic mobility impairment in anaerobically digested sludge [0.03%]
高铁酸盐（Fe(VI)）抑制厌氧消化污泥中抗生素抗性基因的双路径作用：氧化失活和遗传迁移力抑制
Tianyi Luo,Xiaohu Dai,Yuting Zhang et al.
Tianyi Luo et al.
Antibiotic resistance genes (ARGs) and antibiotic resistant bacteria (ARB) are emerging environmental contaminants that threaten public health, highlighting the urgent need for effective control strategies. Ferrate (Fe(VI)), a strong and ec...
Copper Activates a Redox Switch to Reversibly Inhibit Glyceraldehyde-3-Phosphate Dehydrogenase [0.03%]
铜通过激活氧化还原开关可逆地抑制甘油醛-3-磷酸脱氢酶
Taylor C Outlaw,Amy T R Robison,Natalie B Schulte et al.
Taylor C Outlaw et al.
Although the anaerobic binding of Cu+ or Ag+ moderately diminishes catalytic turnover, these ions sensitize the protein to rapid and complete oxidative inactivation in the presence of oxygen. Oxidative modification of the active site cysteine, including glutathionylation, is reversible.
Pouya Sobhifar,David R Brown
Pouya Sobhifar
Loss-of-function of DJ-1 was reported to cause familial PD, and oxidative inactivation of DJ-1 has been observed in sporadic cases, suggesting that both genetic and post-translational events converge on common disease pathways.
A kinetic and spectroscopic study of tetrahydrodipicolinate N-succinyltransferase (DapD) from Serratia marcescens and its inactivation by Cu2 [0.03%]
产红恶臭单胞菌四氢吡啶酸N-琥珀酰基转移酶(DapD)的动态学和光谱研究及铜离子对其灭活作用的研究
Benjamin Hayes,Mason Zuelzke,Abigail M Smith et al.
Benjamin Hayes et al.
These data suggest Cu2+ binding to the enzyme as well as an oxidative inactivation that results in significant structural changes and denaturing.
Receptor Tyrosine Kinase Profiling Identifies Chronic Constitutive Floodgate Oxidative Signaling in Glutathione-Independent Human Mammary Luminal Progenitor Cells [0.03%]
受体酪氨酸激酶谱分析在谷胱甘肽非依赖的人类乳腺导管祖细胞中鉴定慢性组成型泛闸氧化信号
Syed Musheer Mohammed Aalam,Megan L Ritting,Hari Ps et al.
Syed Musheer Mohammed Aalam et al.
In mammary gland, phosphorylation of the antioxidant enzyme PRDX1 is selectively detected in LPs, consistent with a floodgate model of redox signaling in which transient oxidative inactivation of peroxiredoxins (PRDXs) facilitates RTK signaling under elevated intracellular reactive oxygen species conditions
The common homocystinuria-associated P1173L variant of human methionine synthase impairs reductive methylation [0.03%]
同型半胱氨酸尿症相关的常见P1173L突变型人甲基钴胺素酶甲基化功能受损
Arkajit Guha,Ruma Banerjee
Arkajit Guha
The enzyme is susceptible to oxidative inactivation and is repaired by methionine synthase reductase (MTRR) in the presence of NADPH and S-adenosylmethionine (AdoMet).
Functional Characterization of MIP_07528 of Mycobacterium indicus pranii for Tyrosine Phosphatase Activity Displays Sensitivity to Oxidative Inactivation and Plays a Role in Immunomodulation [0.03%]
Mycobacterium indicus pranii的MIP_07528蛋白具有酪氨酸磷酸酶活性并参与免疫调节且易被氧化失活
Raunak Raunak,Roopshali Rakshit,Aayush Bahl et al.
Raunak Raunak et al.
The recombinant protein exhibited distinctive kinetic properties, characterized by higher substrate affinity yet increased susceptibility to oxidative inactivation compared to its M. tuberculosis counterpart.
Enzymatic saccharification of peat polysaccharides is limited by accessibility [0.03%]
peat多糖的酶促糖化受其可及性限制
Jonas Thomsen,Signe Lett,Helle J Martens et al.
Jonas Thomsen et al.
With an iron content of 2 g/kg dry peat, oxidative inactivation of enzymes is an important factor to take into account....A high inactivation constant of 125.91 x10-3 h-1 was found for the used saccharification conditions, but the addition of catalase alleviated the oxidative inactivation and increased the glucose yield with 60% in peat pretreated at 180 °C.
Cytoglobin scavenges intracellular hydrogen peroxide and regulates redox signals in the vasculature [0.03%]
细胞球蛋白能清除血管内的氢氧自由基并调节其信号分子的活性
Frances Jourd&#x;heuil,Clinton Mathai,Le Gia Cat Pham et al.
Frances Jourd&#x;heuil et al.
In addition, the ectopic expression of cytoglobin in cultured cells limited the inhibitory effect of H2O2 on glycolysis and reversed the oxidative inactivation of the glycolytic enzyme GAPDH. Cytoglobin facilitated the reduction of the thiol-based H2O2 sensor Hyper7 after H2O2 challenge.
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