Structure-based analysis of heme oxygenase subtype-selective inhibition activity of tumor-initiating cell near-infrared probe: a promising therapeutic agent for metastatic lung cancer [0.03%]
基于结构的肿瘤启动细胞近红外探针亚型选择性抑制活性分析：一种有前途的转移性肺癌治疗剂
Chi-Ho Lee,Seul-Ki Mun,Ji-Hun Jang et al.
Chi-Ho Lee et al.
Recently, tumor-initiating cell near-infrared probe (TiNIR) was identified as a selective HMOX-2 inhibitor, yet its molecular mechanism and selectivity remain unexplored. This study elucidates TiNIR's HMOX-2 selective binding mechanism by integrating molecular modeling and in-vitro assays.
A transcriptional recognition site within SOS1 coding region controls salt tolerance in Arabidopsis [0.03%]
阿拉伯芥SOS1编码区内的一个转录识别位点控制其耐盐性
Kai-Kai Lu,Hong Yang,Cai-Yi Liao et al.
Kai-Kai Lu et al.
Collectively, our study identifies a transcriptional cis-element within SOS1 coding region recognized by ARF7 and ARF19 and elucidates a molecular mechanism governing ARF7 and ARF19 protein stability and SOS1 expression during plant salt stress response.
Mechanism of the Oxygen-Evolving Process in the Water-Oxidizing Complex of Photosystem II, as Revealed by Time-Resolved Infrared Spectroscopy [0.03%]
时间分辨红外光谱揭示的光系统II中水氧化复合物的氧释放机制
Kiichi Sugie,Yuki Kato,Ryo Nagao et al.
Kiichi Sugie et al.
The molecular mechanism of photosynthetic water oxidation in photosystem II was investigated, focusing on the elusive O2-evolving S3 → S0 transition using time-resolved infrared spectroscopy, supported by quantum mechanics/molecular mechanics calculations....These results highlight the key role of the hydrogen-bond network in the catalytic site in the molecular mechanism of the O2-evolving process, the slowest step in photosynthetic water oxidation.
GMPS inhibits the proliferation and migration of non-small cell lung cancer via the regulation of the DNMT 1/SERPINB2 axis [0.03%]
GMPS通过调控DNMT 1/SERPINB2轴抑制非小细胞肺癌的增殖和迁移
Tingting Guo,Lei Liu,Lingyan Zeng et al.
Tingting Guo et al.
Studies have shown that Guanosine monophosphate synthase (GMPS) may serve as a potential drug target, but its biological function and molecular mechanism in NSCLC are still unknown....The molecular mechanism of GMPS affecting the metastasis of lung cancer cells was elucidated.
Ghadah H Alshehri,Hayder M Al-Kuraishy,Huda Jaber Waheed et al.
Ghadah H Alshehri et al.
Consequently, this mini-review aims to discuss the possible molecular mechanism of TRZ in AD.
R-2-hydroxyglutarate-mediated inhibition of KDM4A compromises telomere integrity [0.03%]
R-2-羟基谷氨酸通过抑制KDM4A损害端粒的完整性
Florence Couteau,Laurence M Gagné,Karine Boulay et al.
Florence Couteau et al.
However, the precise molecular mechanism through which inhibition of αKG-dependent enzymes by R-2HG promotes gliomagenesis remains poorly understood. Here, we show that treatment with R-2HG induces cellular senescence in a p53-dependent manner.
P53-Induced Autophagy Degradation of NKX3-2 Improves Ovarian Cancer Prognosis [0.03%]
p53诱导的自噬降解NKX3-2蛋白改善卵巢癌预后
Alessandra Ferraresi,Ian Ghezzi,Amreen Salwa et al.
Alessandra Ferraresi et al.
Given the prominent role of the latter oncosuppressor in controlling DNA repair and cell death, here we investigate the molecular mechanism involved in this negative correlation in several ovarian cancer cell lines expressing different levels of the two proteins.
Accelerated Photochemical Generation of Reactive Species in Microdroplets by Humic-Like Substances: Role of the Air-Water Interface and Molecular Mechanism [0.03%]
腐殖酸类似物通过空气-水界面在纳微滴中光化学加速生成反应性物质及其分子机制研究
Longgang Chu,Haoran Yu,Xinhao Wang et al.
Longgang Chu et al.
Atmospheric humic-like substances (HULIS) are crucial components of aerosols that absorb light and produce reactive species, influencing air quality, climate change, and human health. However, most studies on the photochemical processes of ...
Effect of miR-29a-3p on renal interstitial fibrosis in diabetic kidney disease through FOXP1-mediated TGF-β1/Smad3 signaling pathway [0.03%]
miR-29a-3p通过FOXP1介导的TGF-β1/Smad3信号通路对糖尿病肾病肾间质纤维化的影响研究
Juntai Zhang,Yan Qin,Jie Liu et al.
Juntai Zhang et al.
This study is the first to propose the specific molecular mechanism of miR-29a-3p in renal interstitial cells in DKD, which provides novel targets and strategies for the clinical treatment of RIF-related DKD.
Deciphering mitochondrial dysfunction in keratoconus: Insights into ACSL4 from machine learning-based bulk and single-cell transcriptome analyses and experimental validation [0.03%]
角膜扩张症中线粒体功能障碍的解析：基于机器学习的批量和单细胞转录组分析以及ACS L4的实验验证见解
Yuchen Cai,Tianyi Zhou,Xueyao Cai et al.
Yuchen Cai et al.
These findings suggest a mitochondrial-related molecular mechanism implicated in KC pathogenesis.
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