Tumor-associated neutrophils and neutrophil extracellular traps in lung cancer: antitumor/protumor insights and therapeutic implications [0.03%]
肺癌相关的肿瘤相关中性粒细胞和中性粒细胞胞外陷阱：抗肿瘤/促肿瘤作用及治疗意义
Milad Sheervalilou,Mostafa Ghanei,Masoud Arabfard
Milad Sheervalilou
TANs exhibit both protumor and antitumor functions, either promoting lung cancer progression through enhanced tumor cell proliferation, invasion, angiogenesis, and metastasis or exerting antitumor effects by stimulating immune responses and cytotoxicity.
Interpretable deep fuzzy network-aided detection of central lymph node metastasis status in papillary thyroid carcinoma [0.03%]
基于解释性深度模糊网络的乳头状甲状腺癌中央区淋巴结转移状态检测方法研究
Wenxu Wang,Zhenyuan Ning,Jifan Zhang et al.
Wenxu Wang et al.
Purpose: The non-invasive assessment of central lymph node metastasis (CLNM) in patients with papillary thyroid carcinoma (PTC) plays a crucial role in assisting treatment decision and prognosis planning....Pathological diagnosis served as the gold standard to determine metastasis status. Clinical and morphological features of thyroid were collected as expert knowledge to guide the deep fuzzy network in predicting CLNM status.
Effects of Thymidine Phosphorylase and Sine Oculis Homeobox Homologue 1 on the Prognosis and Immune Microenvironment of Gastric Cancer [0.03%]
胸苷磷酸化酶和SIX1对胃癌预后及免疫微环境的影响研究
Miao Li,Wei Chen,Yao-Bing Chen et al.
Miao Li et al.
Objective: To investigate the combined effects of thymidine phosphorylase (TYMP) and sine oculis homeobox homologue 1 (Six1) on the tumor microenvironment and their role in promoting metastasis in gastric cancer (GC).
Development and validation of machine learning models for distant metastasis of primary hepatic carcinoma: a population-based study [0.03%]
基于人群的机器学习模型在肝细胞癌转移中的发展与验证研究
Cong Lu,Ying He,Chun-Ru Chen et al.
Cong Lu et al.
Patients with distant metastasis (PLCDM) have particularly low survival rates and are more difficult to treat....This study aims to identify risk factors associated with distant metastasis and overall survival (OS) in primary liver cancer and to determine the optimal predictive models using machine learning....Methods: We extracted data from the SEER database (Incidence-SEER Research Data, 17 Registries, Nov 2022 Sub (2000-2020)) and identified risk factors for distant metastasis using logistic regression.
The need for screening recommendations after intestinal vaginal replacement: a systematic review of the literature [0.03%]
肛肠代阴道术后筛查需求的系统评价
Catherine C Dawson-Gore,Lauren Evans,Sage Vincent et al.
Catherine C Dawson-Gore et al.
Fifty percent of patients presented with local disease (n = 8), 31% with locoregional (n = 5) and 6% with metastasis (n = 1). Treatment varied with most patients undergoing surgical resection. Survival was reported for 10 patients, half of which experienced disease recurrence.
Hypoxanthine activates PI3K/AKT pathway and lipid metabolism, hallmarks in breast cancer metastasis [0.03%]
次黄嘌呤通过激活磷脂酰肌醇三磷酸激酶/蛋白激酶B信号途径和脂质代谢，促进乳腺癌的转移
Sarra B Shakartalla,Amal Bouzid,Alaa M Altaie et al.
Sarra B Shakartalla et al.
Collectively, our results highlight the contribution of HYP to cancer cell metastasis through the PI3K/AKT pathway.
Prevalence of Level IB Metastasis in Surgically-Treated p16+ Oropharyngeal Squamous Cell Carcinoma [0.03%]
p16阳性下咽癌中IB期淋巴结转移的分布规律及其外科治疗意义
Alexander Michael,Madia Russillo,Aditi Katwala et al.
Alexander Michael et al.
Background: Surgical management of oropharyngeal p16 positive squamous cell carcinoma (p16+ OPSCC) often includes neck dissection, however the prevalence of level IB metastasis is not widely reported....Our study aims to determine the prevalence of level IB nodal metastasis in p16+ OPSCC to help determine if level IB should routinely be included in neck dissection....Methods: We assessed a 102 patient cohort of surgically treated p16+ OPSCC to determine the prevalence of level IB metastasis among patients that underwent neck dissection and TORS....No patients in this cohort were found to have metastasis to levels V or VI. Nine patients (8.8%) were found to have recurrence of any kind.
Li Jia,Lijuan Zhang,Dongjie Wang et al.
Li Jia et al.
FISH was used to detect circRAPGEF5 expression in LUAD tissues. circRAPGEF5 knockdown inhibited LUAD cell proliferation, migration, and invasion as well as tumor growth and metastasis in vivo....Collectively, our findings indicated that circRAPGEF5 facilitates LUAD progression and metastasis by stabilizing HOXC6 mRNA via HNRNPC and promoting HOXB2 transcription.
Cancer-Associated Fibroblast-Derived RIPK4 Confers Cisplatin Resistance in Gastric Cancer by Activating the PI3K/AKT Pathway [0.03%]
癌相关成纤维细胞衍生的RIPK4通过激活PI3K / AKT途径介导胃癌对顺铂的抗性
Rui Chen,Junfang Dai,Bo Wang et al.
Rui Chen et al.
Receptor Interacting Serine/Threonine Kinase 4 (RIPK4) was demonstrated to promote gastric cancer (GC) metastasis and tumorigenesis. Here, this study aimed to explore whether GC-derived CAFs affected cisplatin (DDP) resistance in GC cells via RIPK4. DDP-resistant GC cells were first established.
LncRNA SNHG14 Regulated by ZNF460 Promotes Gastric Cancer Progression and Metastasis by Targeting the miR-206/FNDC3A Axis [0.03%]
ZNF460调控的长链非编码RNA SNHG14通过靶向miR-206/FNDC3A轴促进胃癌进展和转移
Bin Liu,Tingting Lu,Guangming Zhang et al.
Bin Liu et al.
The current study investigated the functional role of long non-coding RNA SNHG14 (lncRNA SNHG14) in gastric cancer (GC) progression and its underlying mechanisms. Compared with para-carcinoma tissues, SNHG14 was upregulated in GC tissues, c...
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