Hypoxanthine activates PI3K/AKT pathway and lipid metabolism, hallmarks in breast cancer metastasis [0.03%]
次黄嘌呤通过激活磷脂酰肌醇三磷酸激酶/蛋白激酶B信号途径和脂质代谢，促进乳腺癌的转移
Sarra B Shakartalla,Amal Bouzid,Alaa M Altaie et al.
Sarra B Shakartalla et al.
Metastasis is the primary cause of death in women with breast cancer, which ranks among the most prevalent malignant diseases. Recently, we identified the significant metastatic role of hypoxanthine (HYP) in cancer cells. HYP is a naturally...
Association of High-Density Lipoprotein Cholesterol-Based Inflammatory Markers with MASLD and Significant Liver Fibrosis in US Adults: Insights from NHANES 2017-2020 [0.03%]
美国成年人中基于高密度脂蛋白胆固醇的炎症标志物与MASLD和显著肝纤维化的关联：来自NHANES 2017-2020的见解
Shuangzhen Jia,Xiaolin Ye,Yan Kong et al.
Shuangzhen Jia et al.
Background: Systemic inflammation and lipid metabolism disturbances are important hallmarks of the onset and progression of metabolic dysfunction-associated steatotic liver disease (MASLD).
Amanda S Mondschein,Mathieu R DiPersio,Julia Zajaceskowski et al.
Amanda S Mondschein et al.
Myelin defects and PMP2 upregulation suggest that altered lipid metabolism contributes to neuropathy progression.
Bicuculline ameliorates metabolic dysfunction-associated steatotic liver disease by inhibiting the nuclear factor-kappa B pathway and reducing lipid accumulation [0.03%]
bicuculline通过抑制核因子-κB通路和减少脂质积累来改善与代谢功能障碍相关的肝脂肪变性疾病
Xiao-Mei Wang,Ze Dai,Dai-Jun Lu et al.
Xiao-Mei Wang et al.
Aim: To determine BIC's efficacy in treating MASLD by regulating lipid metabolism and suppressing hepatic inflammation via nuclear factor-kappa B (NF-κB) pathway, identifying it as a therapeutic candidate.
Bicuculline ameliorates metabolic dysfunction-associated steatotic liver disease by inhibiting the nuclear factor-kappa B pathway and reducing lipid accumulation [0.03%]
bicuculline通过抑制核因子-κb通路和减少脂质积累来改善与代谢功能障碍相关的肝脂肪变性疾病
Xiao-Mei Wang,Ze Dai,Dai-Jun Lu et al.
Xiao-Mei Wang et al.
Aim: To determine BIC's efficacy in treating MASLD by regulating lipid metabolism and suppressing hepatic inflammation via nuclear factor-kappa B (NF-κB) pathway, identifying it as a therapeutic candidate.
Hepatic Lipidomics Unravels the Lipid-Lowering and Anti-Obesity Efficacy of Diacylglycerol Oil: Mechanistic Insights From High-Fat Diet-Induced Obese Mice [0.03%]
肝脏脂质组学揭示二酰甘油油的降脂和抗肥胖功效：高脂饮食诱导的小鼠肥胖模型中的机制见解
Lina Shi,Yiran Liu,Yuanyuan Yan et al.
Lina Shi et al.
Mechanistically, DAG suppressed the expression of stearoyl-CoA desaturase 1 and fatty acid synthase, while upregulating carnitine palmitoyltransferase 1, thereby enhancing hepatic lipid metabolism through dual regulation: inhibition of synthesis and promotion of catabolism and oxidation.
Identification of lipid metabolism-related marker genes in colorectal cancer [0.03%]
结直肠癌中与脂质代谢相关的标记基因识别
Bo Gao,Jitao Hu,Hao Wu et al.
Bo Gao et al.
Objective: To identify lipid metabolism associated biomarkers in colorectal cancer (CRC).
Cholesterol metabolism reprogramming in multiple myeloma: examining its specificity and impact on the immune microenvironment [0.03%]
胆固醇代谢在多发性骨髓瘤中的重新编程：考察其特异性和对免疫微环境的影响
Hongtao Teng,Feifei Wang,Hairui Liu et al.
Hongtao Teng et al.
Analyzing the correlation between immune cell proportions in the tumor microenvironment and lipid metabolism genes has unveiled potential links between cholesterol metabolism and immune responses, paving the way for precision medicine in MM.
The analysis of distinctive lipid metabolism characteristics in dry-cured beef during processing [0.03%]
干腌肉制品加工过程中脂质代谢特征分析
Huihui Fu,Jiaxin Jin,Sheng Xiao et al.
Huihui Fu et al.
Dry-cured beef (DB), CG (control group), FG (fermented group), RG (ripened group) stages were selected to analyse the key lipid metabolites using the lipid metabolism approach based on UPLC-MS/MS. We identified 301 metabolites from 13 subclasses, with 80 markedly different lipids.
Dysregulated lipid metabolism in late preterm low birth weight neonates: A case-control study on maternal lipid levels and early metabolic programming implications [0.03%]
极低体重晚产新生儿脂质代谢紊乱：一项关于母亲脂质水平和早期代谢程序影响的病例对照研究
Jing Liu,Lijuan Tang,Qi Sun et al.
Jing Liu et al.
Objectives: While low birth weight (LBW) is a recognized risk factor for adult metabolic syndrome, the unique lipid metabolic phenotype of late preterm low birth weight (LPTB-LBW) neonates-who experience dual exposures to...
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