Predictors of Hypocalcemia Post Parathyroidectomy for Primary Hyperparathyroidism; a Single Center Study [0.03%]
甲状旁腺功能亢进术后低钙血症的预测因素：单中心研究
Khaled A Obeidat,Nesreen A Saadeh,Renad Msameh et al.
Khaled A Obeidat et al.
Results: Of the 116 patients studied, 57.7% developed hypocalcemia after parathyroidectomy....High preoperative alkaline phosphatase (ALP), low preoperative corrected calcium, high preoperative parathyroid (PTH), and younger age were shown to be significantly higher in patients who developed hypocalcemia after parathyroidectomy....Multivariate logistic regression showed a low preoperative corrected calcium level was an independent predictor of postoperative hypocalcemia (p = 0.036)....A high level of preoperative alkaline phosphatase was also considered an independent predictor of hypocalcemia development (OR = 1.007, 95% CI: 1.002-1.012)....Preoperative ALP and preoperative corrected calcium were shown to be independent predictors of hypocalcemia development.
Raj Roy,Abhirami Babu,Zhixing Song et al.
Raj Roy et al.
Transient hypocalcemia or hypoparathyroidism was defined as a drop in serum calcium below laboratory reference range postthyroidectomy that resolved within 6 mo....Common complications like transient hypocalcemia or hypoparathyroidism was found in 24% (95% CI: 0.2-0.3, I2 = 91%) and transient laryngeal nerve injury was 2% (95% CI: 0.01-0.02, I2 = 35%) of patients....Permanent hypocalcemia or hypoparathyroidism was found in 3% (95% CI: 0.02-0.04, I2 = 65%) patients....Conclusions: Pediatric thyroid surgery, although safe, has a high risk of transient hypocalcemia or hypoparathyroidism. Other complications remain under 3%.
Denosumab-bbdz: A Review of the Interchangeable Biosimilar for the Treatment of Osteoporosis [0.03%]
关于抗骨质疏松药物地舒单抗生物类似药的综述文章
Kaitlyn North,Brandi Dahl,KariLynn Dowling-McClay et al.
Kaitlyn North et al.
Denosumab-bbdz carries a boxed warning and Risk Evaluation and Mitigation Strategy for severe hypocalcemia in patients with advanced chronic kidney disease.Relevance to Patient Care and Clinical Practice in Comparison to Existing Drugs:Denosumab-bbdz has interchangeable status which allows substitutions
Late-onset Complications in a Chronic Proton Pump Inhibitor User: Electrolyte Abnormalities and a Diagnostic Approach [0.03%]
长期服用质子泵抑制剂患者的迟发并发症：电解质异常及诊断方法
Danielle H Tran,Jason R Fredrick,Radhika R Narla
Danielle H Tran
First, it underscores the importance of recognizing that refractory hypocalcemia and hypokalemia can often be linked to untreated hypomagnesemia so that timely diagnosis, effective management, and minimization of hospitalizations can be ensured....Second, this case highlights the unusual timing of symptomatic hypomagnesemia and subsequent hypocalcemia and hypokalemia despite years of prior PPI usage without prior known complications.
Case Reports
JCEM case reports. 2025 Jun 9;3(7):luaf125. DOI:10.1210/jcemcr/luaf125 2025
Outcomes of Hypoparathyroidism in Pregnancy: An Observational Study from a Tertiary Canadian Center [0.03%]
妊娠低甲状旁腺素血症的结局：来自加拿大三级医疗中心的一项观察性研究
Dalal S Ali,Habiba Afifi,Hajar Abu Alrob et al.
Dalal S Ali et al.
The findings suggest that nonsurgical HypoPT presents a greater risk for preterm delivery and neonatal hypocalcemia requiring NICU admission.
Giant Parathyroid Adenomas: A 28-Year Experience at a Tertiary Super-Specialty Hospital [0.03%]
巨大甲状旁腺腺瘤的外科治疗——一家三级专科医院28年的经验
Gopal Puri,Piyush Ranjan,Brijesh Kumar Singh et al.
Gopal Puri et al.
Symptomatic postoperative hypocalcemia was seen in 54 (69%), with 28 (36%) requiring intravenous calcium supplementation, and this was positively correlated with the preoperative ALP and PTH values.
Novel TRPM3 missense mutation leading to severe hypocalcemia presenting as seizures and complicated by non-sustained ventricular tachycardia: A case report [0.03%]
TRPM3新错义突变致重度低钙血症并发癫痫及非持续性室速的病例报告
Pyrus Bhellum,Shekhar Angirekula,Amit Kumar Rohila et al.
Pyrus Bhellum et al.
Diagnostic evaluation revealed severe hypocalcemia with hypomagnesemia, QT prolongation, and episodes of non-sustained ventricular tachycardia. The condition was managed with calcium and magnesium supplementation....Discussion: Hypocalcemic seizures are rare in adults and are typically associated with severe hypocalcemia and cardiovascular instability, including ventricular dysrhythmias.
Ionized calcium and ionized magnesium disturbances in dogs and cats with septic peritonitis [0.03%]
脓性腹膜炎犬和猫的离子钙及镁的变化
Chiara Debie,Laure Giberto,Stéphanie Noel et al.
Chiara Debie et al.
Ionized hypocalcemia was associated with plasma administration in dogs (p = 0.038). No significant correlation was found between iCa and iMg disturbances and length of hospitalization in dogs (respectively p = 0.62 and p = 0.62) or cats (respectively p = 0.62 and p = 0.27)....Dogs and cats with hypocalcemia were more likely to receive plasma. Mean iMg values were lower in survived dogs than dogs that did not survive.
Gitelman Syndrome in the Sixth Decade: An Atypical Presentation with Severe Electrolyte Abnormalities and Genetic Heterogeneity [0.03%]
Gitelman综合征六十年代的非典型表现及其严重的电解质紊乱和遗传异质性
Sachin Shivnitwar,Sandesh S Raut,Shubhangi Kanitkar et al.
Sachin Shivnitwar et al.
We report a case of a 60-year-old female who presented with generalized weakness, lethargy, and severe electrolyte abnormalities, including profound hyponatremia (109 mmol/L), hypokalemia (2.91 mmol/L), hypocalcemia (
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