Jiawen Dong,Kaitlyn M J H Dennis,Radha Venkatakrishnan et al. Jiawen Dong et al.

Despite the changing attitudes to HRT and the strong evidence base implicating estrogen deficiency in the development of MASLD, the impact of HRT on MASLD in postmenopausal women is poorly studied....In this review, we discuss the burden of MASLD in women, the effect of estrogen deficiency on the processes that drive MASLD development and progression, and explore potential sex-specific therapeutic strategies that may prevent or limit MASLD development after menopause.

Lanying Yang,You Wu,Yiyun Du et al. Lanying Yang et al.

Furtherly, steroid profiling confirmed cyp17a1-/--specific androgen and estrogen deficiency (T, 11-KT, E1, and E2), while revealing dko-specific deficiencies in DHP, cortisol, and cortisone, alongside an overaccumulation of corticosterone, highlighting paralog-specific substrate preferences.

Sukanya Phungphong,Phichaya Suthivanich,Worakan Boonhoh et al. Sukanya Phungphong et al.

Cardiac diastolic dysfunction is a hallmark of diabetic cardiomyopathy (DCM), particularly in postmenopausal women where estrogen deficiency exacerbates cardiac remodeling....These findings suggest that NLRP3 inflammasome activation under conditions of estrogen deficiency and diabetes contributes to myocardial pyroptosis and mast cell degranulation, driving cardiac remodeling in postmenopausal DCM.

Siyu-Yang,Ruibing-Sun,Liqing-Wang et al. Siyu-Yang et al.

Chronic obstructive pulmonary disease (COPD), one of the most prevalent respiratory diseases worldwide, exhibits marked gender disparities, with women disproportionately affected. Current therapeutic modalities for COPD are relatively ineff...

Wena Dantas Marcarini,Vinicius Bermond Marques,Ariane Calazans Teixeira et al. Wena Dantas Marcarini et al.

Inhibition of the renin-angiotensin system prevents vascular dysfunction induced by estrogen deficiency in rats. However, the role of aldosterone in ovarian hormone deficiency-related vascular dysfunction is unclear.

Meng Gao,Sai Zhang,Jing Zhao et al. Meng Gao et al.

Here, a rat model of F exposure (0, 25, 50, 100 mg/L in drinking water) combined with ovariectomy (OVX)-induced estrogen deficiency was established to investigate the roles of nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway in F-induced colonic damage under the state...OVX-induced estrogen deficiency exacerbated F-induced colonic barrier damage and SCFA decreased....Mechanistically, estrogen deficiency aggravated F intestinal toxicity by further inhibiting the protein expression of Nrf2 and HO-1 and upregulating Keap1 protein expression, following downregulated Bcl-2 mRNA levels and upregulated Bax and caspase-3 mRNA levels, and promoting colonic epithelial cell...These findings identify that Nrf2/HO-1 key protein disorders are involved in F-induced colonic barrier injury, and estrogen deficiency further aggravated F intestinal toxicity.

Satyajit Mohanty,Anwesha Sahu,Tuhin Mukherjee et al. Satyajit Mohanty et al.

Osteoporosis, a debilitating condition characterized by reduced bone mass and increased fracture risk, is notably influenced by estrogen deficiency and glucocorticoid treatment.

Asma Momeni,Mohammad Reza Salahshoor,Mohammadreza Afarinesh et al. Asma Momeni et al.

Conclusion: RJ may protect against estrogen deficiency and seizure-related adverse effects on hippocampal neurons in OVX rats, highlighting its potential as a beneficial dietary supplement.

Miriam Sánchez-García,Kapy León-Wu,Regina de Miguel-Ibáñez et al. Miriam Sánchez-García et al.

Primary ovarian insufficiency (POI), characterized by estrogen deficiency before the age of 40, disrupts this regulatory network, leading to adverse metabolic effects.

Yanwei Fan,Yaokun Yu,Peng Yan Yanwei Fan

Oxidative stress and inflammation lead to high bone turnover, contributing to osteoporosis caused by estrogen deficiency in postmenopausal women.