A SIMPL Model of Phage-Bacteria Interactions Accounting for Mutation and Competition [0.03%]
一个关于噬菌体-细菌相互作用的SIMPL模型（包含变异与竞争）
Carli Peterson,Darsh Gandhi,Austin Carlson et al.
Carli Peterson et al.
Bacteriophage therapy is emerging as a promising approach; however, it remains unapproved for clinical use and is hindered by limited understanding of the complex interactions between bacterial cells and phage virions. Mathematical models provide insight into these interactions.
Aztreonam/avibactam activity against Enterobacterales from European medical centres: summary of 5 years of surveillance prior to approval for clinical use (2019-2023) [0.03%]
2019年至2023年欧洲医学中心肠杆菌目细菌对Aztreonam/Avibactam敏感性的事后监测总结（临床使用获批前五年数据）
Helio S Sader,John H Kimbrough,Marisa L Winkler et al.
Helio S Sader et al.
Objectives: To evaluate the in vitro activity of aztreonam/avibactam against Enterobacterales from European medical centres during the 5-year period prior to its approval for clinical use in Europe.
Higher clozapine concentration-to-dose ratios at week 1 after initiation are associated with increased risk of clozapine-associated fever in Japanese patients with schizophrenia [0.03%]
氯氮平浓度与剂量比率在日本首发分裂症患者治疗第1周时升高与氯氮平所致发热风险增加相关
Yuki Kikuchi,Hiroaki Tanifuji,Mutsumi Sakata et al.
Yuki Kikuchi et al.
Introduction: The clinical use of clozapine in the treatment of schizophrenia is sometimes halted due to its inflammatory side effects. However, no method has been established for preemptively identifying patients who are at high risk for these events.
First-in-human PET imaging and evaluation of melanin-targeted [18F]DMPY2 in malignant melanoma patients [0.03%]
恶性黑色素瘤患者中针对黑色素的正电子发射断层扫描成像以及[18F]DMPY2的首次人体评估研究
Yi Yang,Ming Zhou,Shuang Zhao et al.
Yi Yang et al.
Thirty-one MM patients underwent [18F]DMPY2 and/or [18F]FDG PET/CT scans to explore the clinical use in early detection of melanoma metastasis. Diagnostic performance was assessed in fifty-one LN basins of twenty-seven MM patients after surgery, comparing PET uptake with pathological results.
An Effectiveness and Tolerability of Tapentadol Nasal Spray in Low Back Pain [0.03%]
羟考酮鼻喷雾剂治疗慢性下腰痛的疗效和耐受性研究
Sunil Shetty,Shikhar Singh,Sachin Kale et al.
Sunil Shetty et al.
However, limited real-world data exist on the clinical use of tapentadol nasal spray (NS) in LBP management. This study aimed to evaluate the effectiveness and tolerability of tapentadol NS in patients with LBP.
Traumatic central cord Syndrome: An integrated neurosurgical and neurocritical care perspective [0.03%]
创伤性中央脊髓综合征：神经外科和神经重症监护的综合视角
Karol Martínez-Palacios,Andrés M Rubiano,Andreas K Demetriades et al.
Karol Martínez-Palacios et al.
Experimental and clinical investigations into intraspinal pressure (ISP), mean arterial pressure (MAP), and spinal perfusion pressure (SPP) monitoring suggest these parameters may aid in minimizing secondary injury, though their routine clinical use is not yet established.
Importance of Individualized Pressure Settings in Mechanical Insufflation-Exsufflation for Lung Volume Recruitment: A Case Report [0.03%]
个体化压力设置在机械气道往复挤捏通气肺容量招募中的作用：个案报告
Keiichi Funo,Toshio Fukutake,Ryoko Takeuchi et al.
Keiichi Funo et al.
Although the clinical use of pressure settings in MI-E varies, inspiratory pressure levels around 40 cmH₂O are sometimes applied in practice. However, such settings may result in patient discomfort and raise safety concerns.
Case Reports
Cureus. 2025 May 16;17(5):e84211. DOI:10.7759/cureus.84211 2025
The hormonal regulation of men's sexual desire, arousal, and penile erection: recommendations from the fifth international consultation on sexual medicine (ICSM 2024) [0.03%]
男性性欲、勃起功能和阴茎勃起的激素调节：第五届国际性医学咨询大会(ICSM 2024)推荐意见
Giulia Rastrelli,Leen Antonio,Serge Carrier et al.
Giulia Rastrelli et al.
Others may be important, but the clinical use is limited by issues with their measurement (ie, estradiol, dihydrotestosterone), whereas for some hormones or neuropeptides, the clinical usefulness for diagnostic and/or therapeutic purposes should still be established.
The secret life of complement: challenges and opportunities in exploring functions of the complosome in disease [0.03%]
补体的隐秘人生：探索疾病状态下补体复合物功能的挑战与机遇
Tilo Freiwald,Behdad Afzali
Tilo Freiwald
Current complement-targeting therapeutics for clinical use almost exclusively target the complement system in circulation.
Gene Therapy with covalently-closed-end AAV vector for Spinal Muscular Atrophy [0.03%]
用于治疗脊髓性肌萎缩症的基因疗法用共价封闭端腺相关病毒载体
Haolin Duan,Ciliu Zhang,Zhongliang Zhang et al.
Haolin Duan et al.
These early data provide preliminary evidence for clinical use of cceAAV vectors, though further validation in larger cohorts is warranted. Copyright © 2025. Published by Elsevier Inc.
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