Alternative transcription increases isoform complexity in Long Non-Coding RNAs and alters their functions in cancer [0.03%]
选择性转录增加长非编码RNA的异构体复杂性和其在癌症中的功能作用
Max Bone,Gareth J Inman
Max Bone
Transcriptional start and end variance, a less-explored aspect of lncRNA biology, is a critical determinant of isoform diversity in human RNA. While alternative splicing (AS) has been extensively studied as a mechanism of isoform generation...
Prediction and annotation of alternative transcription starts and promoter shift in the chicken genome [0.03%]
鸡基因组中可变转录起始和启动子转换的预测及注释
Valentina A Grushina,Ivan S Yevshin,Oleg A Gusev et al.
Valentina A Grushina et al.
Promoter shifting, characterized by alterations in Transcription Start Site (TSS) coordinates, is a well-documented phenomenon. The impact and statistical significance of promoter shifting can be assessed through analysis of Cap Analysis of...
DNA Methylation and Alternative Splicing Safeguard Genome and Transcriptome After a Retrotransposition Burst in Arabidopsis thaliana [0.03%]
拟南芥爆发逆转座后其基因组和转录组通过DNA甲基化和选择性拼接得以保护
Pavel Merkulov,Anastasiia Latypova,Kirill Tiurin et al.
Pavel Merkulov et al.
In some cases, ONSEN insertions provided alternative transcription start or termination sites, generating novel transcript isoforms. Genome-wide methylation analysis revealed that new ONSEN copies were efficiently and precisely targeted by DNA methylation.
Benpeng Miao,Xinlong Luo,Amina Ademovic et al.
Benpeng Miao et al.
Our results demonstrated that TE-derived alternative transcription initiation significantly enhances the variety of translated protein products, e.g., changes in the N-terminal peptide length of WNT2B caused by TE-derived transcription result in isoform-specific subcellular localization.
Kevin Vo,Sharmin Shila,Yashica Sharma et al.
Kevin Vo et al.
This complex phenomenon arises from various mechanisms, such as using alternative transcription start sites and alternative post-transcriptional processing events.
Biosurfer for systematic tracking of regulatory mechanisms leading to protein isoform diversity [0.03%]
Biosurfer系统追踪导致蛋白质异构体多样性的调节机制
Mayank Murali,Jamie Saquing,Senbao Lu et al.
Mayank Murali et al.
Using Biosurfer, we analyzed the differences in 35,082 pairs of GENCODE annotated protein isoforms, finding a majority (70%) of variable N-termini are due to the alternative transcription start sites, while only 9% arise from 5' UTR alternative splicing (AS).
Deciphering the landscape of cis-acting sequences in natural yeast transcript leaders [0.03%]
天然酵母转录本5’非翻译区的顺式作用序列的解读
Christina Akirtava,Gemma E May,C Joel McManus
Christina Akirtava
In addition, our work quantitated the effects of alternative transcription start site usage on gene expression in yeast. Thus, our study provides new quantitative insights into the roles of TL cis-acting sequences in regulating gene expression.
Rilu Feng,Roman Liebe,Hong-Lei Weng
Rilu Feng
hepatic transcription factors, such as hepatic nuclear factor 4 alpha (HNF4α) and CCAAT-enhancer binding protein α (C/EBPα), which ensure normal liver function; (2) When the expression of both HNF4α and C/EBPα in hepatocytes are disrupted by severe inflammation, retinoic acid receptor (RAR) is the alternative...transcription factor that compensates for their absence; (3) When massive hepatic necrosis occurs, a similar transcription network including FOXA2 and HNF4α, is activated as a "rescue network" in LPCs to maintain vital liver functions when hepatocytes fail, and thus ensures survival.
Comprehensive transcriptomic analysis reveals turnip mosaic virus infection and its aphid vector Myzus persicae cause large changes in gene regulatory networks and co-transcription of alternative spliced mRNAs in Arabidopsis thaliana [0.03%]
全面的转录组分析揭示了油菜花叶病毒和其蚜虫介体对基因表达调控网络及拟南芥可变剪切基因共转录的较大影响
Venura Herath,Clare L Casteel,Jeanmarie Verchot
Venura Herath
This study also shows that gene expressions are regulated through alternative pre-mRNA splicing and the use of alternative transcription start and termination sites.
Xinlu Li,XiaoJing Dong,Wen Zhang et al.
Xinlu Li et al.
Integrated scRNA-seq and transcriptomic analyses have revealed novel insights into DR pathogenesis, including alternative transcription start site events, fluctuations in cell populations, altered gene expression profiles, and critical signaling pathways within retinal cells.
耗时 0.19586 秒，为您在
48229835
条记录里面共找到 501 篇文章 [XML]