Yunzhuo Xin,Rou Wen,Dong Song et al. Yunzhuo Xin et al.

We established a mouse model of ovalbumin (OVA)-induced allergic asthma and found that emu-miR-10a-5p alleviated pulmonary inflammation in mice with allergic asthma while inhibiting the accumulation of pulmonary M2a macrophages. emu-miR-10a-5p intervention inhibited LIF and JAK1-STAT3 signaling in the

Ya-Ru Liang,Chuan-Hsin Chang,Shiang-Yu Huang et al. Ya-Ru Liang et al.

Introduction: Asthma causes airway inflammation, leading to symptoms that impair patients' quality of life, making it a significant global public health issue. Inhaled corticosteroids (ICS) with long-acting beta-agonists ...

Mervat Kamel Kadhom,Rasha Muzahem Hatem,Khetam Ibrahim Mohammed Mervat Kamel Kadhom

BackgroundThe purpose of this research is to examine whether or not there is a connection between polymorphisms in the IL-5 and IL-9 genes and the prevalence of allergic asthma in Iraqi patients.ObjectiveTo investigate the variants in the genes rs2069812T/C (IL-5) and rs1859430 C/T (IL-9) and their association...Additionally, the allele-specific PCR method was used to identify the polymorphism distribution of rs2069812 (IL-5) and rs1859430 (IL-9).ResultsStudy participants with allergic asthma had significantly higher levels of interleukin (IL)-9 and interleukin (IL)-5 than those in the healthy subjects: 2 and...Thus, the TG genotype was associated with an increased risk of allergic asthma illness (etiologic fraction: 0.2963) and an odds ratio of 2.4074 (95% CI: 1.2462-4.6505). The patients' group also had a higher frequency of the homozygous genotype GG (65 cases vs. 54 cases in the control group)....The odds ratio for allergic asthma illness was 1.0578 (95% CI: 0.6386-1.7522), and the etiologic fraction was 0.0299, indicating that genotype GG was a risk factor.ConclusionsThese findings provide more evidence that interleukin-5 and interleukin-9 play critical roles in allergic asthma, particularly...It is clear that IL-5 and IL-9 levels directly influence allergic asthma in patients compared with healthy individuals.

Oh Seong Kwon,Kyu-Taek Hwang,Won Seok Choi et al. Oh Seong Kwon et al.

Herein, we studied the effects of BRL-50481 (BRL), a PDE7 inhibitor, in a murine model of ovalbumin (OVA)-induced allergic asthma with co-exposure to LPS. Mice were sensitized, challenged with OVA, and subsequently exposed to LPS. Mice were administered with BRL prior to the OVA challenge.

Xi Liu,Lie Zhang,Sa Li et al. Xi Liu et al.

In an OVA-induced allergic asthma model, budesonide-loaded high hydrophilic liposomes significantly alleviated symptoms while reducing dosing frequency.

Qiufen Xun,Qing Yang,Wei Wang et al. Qiufen Xun et al.

This study aimed to investigate the specific mechanisms by which GLCCI1 regulated mitochondrial dysfunction in allergic asthma mice....In an ovalbumin (OVA)-induced allergic asthma mouse model, mitochondrial dysfunction in airway epithelium was observed, characterized by reduced ATP production, decreased mtDNA copy number, ROS accumulation, and mitophagy activation (upregulated PINK1/OPTN)....In allergic asthma mice, GLCCI1 overexpression improved airway hyperresponsiveness, reduced inflammatory infiltration, restored alveolar structure, and decreased IL-4/IL-5/IL-13 levels....In summary, GLCCI1 ameliorated mitochondrial dysfunction in allergic asthma mice via the DYRK1A/FAM117B/NRF2 pathway, offering a potential therapeutic target for allergic asthma.

Joel Katan Piñeiro,Ariadna Soledad Soto,Ana Farias et al. Joel Katan Piñeiro et al.

Tolerogenic adjuvants can enhance allergy vaccine efficacy. We previously showed that intranasal administration of recombinant Toxoplasma gondii serine protease inhibitor 1 (rTgPI-1) with ovalbumin alleviates asthma symptoms in mice. This s...

Maria Elpida Christopoulou,Lilia S Panteli,John A Moisidis et al. Maria Elpida Christopoulou et al.

Methods: This retrospective cohort study analyzed medical records of 137 adults with moderate to severe allergic asthma over 12 months. Patients receiving standard of care (SoC) asthma therapy alone (GINA step 4, n = 67) were compared to those on SoC+OM-85 (n = 70).

Romina Campos-Povea,Enrique González-Madrid,Tays Troncoso-Bravo et al. Romina Campos-Povea et al.

Allergic asthma is a chronic respiratory disorder driven by a T helper type 2 (Th2)-mediated immune response that involves eosinophils and mast cell recruitment to affected tissues, eliciting inflammatory cytokines and IgE production. Typic...

Lauren A Chang,Stephen T Yeung,Prajakta Warang et al. Lauren A Chang et al.

Eosinophils are agile cells that participate in a multitude of homeostatic and inflammatory responses in the lung, ranging from allergic asthma to antiviral defense against respiratory viral infection.