Erratum: SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer [0.03%]
校正：SPOP通过降解致癌蛋白ZBTB3抑制子宫内膜癌
Xiaofeng Jin,Jian Wang,Qian Li et al.
Xiaofeng Jin et al.
[This corrects the article on p. 2797 in vol. 9, PMID: 31911863.]. AJCR Copyright © 2025.
Published Erratum
American journal of cancer research. 2025 Jul 25;15(7):3332-3337. DOI:10.62347/IVFL8331 2025
The RNA helicase DDX17 enhances androgen receptor stability by interacting with the E3 ubiquitin ligase SPOP in prostate cancer [0.03%]
RNA解旋酶DDX17通过与SPOP相互作用增强前列腺癌中雄激素受体的稳定性
Maierhaba Maheremu,Bowen Zheng,Haoran Wen et al.
Maierhaba Maheremu et al.
Background: Prostate cancer (PCa) is a common malignancy in men, closely associated with androgen receptor (AR) signaling, and often diagnosed with elevated prostate-specific antigen (PSA). While androgen deprivation ther...
Immune microenvironment heterogeneity characterizes biologically distinct KRASmut/SPOPmut and KRASmut/PIK3CAmut mesonephric-like adenocarcinoma subtypes revealed by integrated whole-exome and transcriptomic profiling [0.03%]
整合外显子组和转录组测序揭示具有生物特性的KRAS突变/SPOP突变和KRAS突变/PIK3CA突变的类似中肾腺癌亚型及其免疫微环境异质性特征
Jing Zeng,Qingli Li,Kemin Li et al.
Jing Zeng et al.
Objective: This study aims to uncover the molecular biology and immune microenvironment of gynecological mesonephric-like adenocarcinoma (MLA). Methods: ...
The equilibrium between two quaternary assembly states determines the activity of SPOP and its cancer mutants [0.03%]
SPOP和癌症突变体活性的两种四聚体装配状态的平衡调控
Matthew J Cuneo,Ömer Güllülü,Mohamed-Raafet Ammar et al.
Matthew J Cuneo et al.
Proteostasis is critical for preventing oncogenesis. Both activating and inactivating mutations in the ubiquitin ligase subunit SPOP result in oncogenesis in different tissues. SPOP assembles into filaments that are multivalent for substrat...
Cancer-associated SPOP mutations enlarge nuclear size and facilitate nuclear envelope rupture upon farnesyltransferase inhibitor treatment [0.03%]
与癌症相关的SPOP突变增大了细胞核的大小，并且在法尼基转移酶抑制剂处理时促进了细胞核膜破裂
Zixi Wang,Lei Li,Qi Ye et al.
Zixi Wang et al.
Nuclear size is crucial for cellular functions and often increases with malignancy. Irregular nuclei are linked to aggressive tumors, driven by genetic and epigenetic changes. However, the precise mechanisms controlling nuclear size are sti...
Integrative Multi-Omics Analysis and Experimental Validation Identify SPOP as a Prognostic Biomarker and Immune Regulator in Lung Adenocarcinoma [0.03%]
整合多组学分析和实验验证识别出SPOP是肺腺癌预后生物标志物和免疫调节因子
Yu Wang,Tao Jiang,Ziyou Lin et al.
Yu Wang et al.
Background: The speckle-type POZ protein (SPOP) has emerged as an important regulator of protein degradation in various cancers. However, the precise role of SPOP in lung adenocarcinoma (LUAD) remains unclear, particularly in relation to it...
SPOP-dependent destabilization of SYT12 in a GSK-3β-dependent manner in papillary thyroid cancer cells [0.03%]
PTC细胞中GSK-3β依赖性的SPOP介导SYT12泛素化降解
Shaocheng Zhou,Qidan Du,Limei Xu et al.
Shaocheng Zhou et al.
Synaptotagmin 12 (SYT12), a protein found to be upregulated in papillary thyroid cancer (PTC), has emerged as a potential biomarker for this malignancy. However, the mechanisms governing its expression remain poorly understood. In this stud...
Discovery of 2-Pyrazolylpyrimidinone Derivatives as New SPOP Inhibitors for Renal Cell Carcinoma Therapy [0.03%]
用于肾细胞癌治疗的新型SPOP抑制剂2-吡唑基嘧啶酮衍生物的发现
Qiong Zhang,Yangguo Zhou,Jinglong Zhao et al.
Qiong Zhang et al.
E3 ligase speckle-type POZ protein (SPOP) is a potential therapeutic target in clear-cell renal cell carcinoma (ccRCC). However, small-molecule inhibitors targeting SPOP are rarely reported. Here, we identified DDO-4033 as a potent SPOP inh...
Author Correction: The role of IGF2BP3/SPOP/c-Myc loop in paclitaxel resistance of endometrial cancer [0.03%]
作者更正：IGF2BP3/SPOP/c-Myc环路在帕利托克斯耐药子宫内膜癌中的作用
Yidong Ge,Lili Kong,Yuxuan Li et al.
Yidong Ge et al.
Published Erratum
Communications biology. 2025 Jul 4;8(1):999. DOI:10.1038/s42003-025-08406-z 2025
Erratum for the Research Article "ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication" by D. Wang et al [0.03%]
王D等关于“ATM磷酸化的SPOP有助于DNA复制过程中53BP1从染色质中排除”的研究论文勘误通知
Published Erratum
Science advances. 2025 Jun 27;11(26):eadz5386. DOI:10.1126/sciadv.adz5386 2025
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