Discovery of 2-Pyrazolylpyrimidinone Derivatives as New SPOP Inhibitors for Renal Cell Carcinoma Therapy
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E3 ligase speckle-type POZ protein (SPOP) is a potential therapeutic target in clear-cell renal cell carcinoma (ccRCC). However, small-molecule inhibitors targeting SPOP are rarely reported. Here, we identified DDO-4033 as a potent SPOP inhibitor through virtu... ...
