Dynamic ensembles of SARS-CoV-2 N-protein reveal head-to-head coiled-coil-driven oligomerization and phase separation [0.03%]
SARS-CoV-2 N蛋白动态集合体揭示了头对头的螺旋桨驱动聚类和相分离
Guillem Hernandez,Maria L Martins,Nuno P Fernandes et al.
Guillem Hernandez et al.
The SARS-CoV-2 nucleocapsid (N) protein is essential for the viral life cycle, facilitating RNA packaging, replication, and host-cell interactions. Its ability to self-assemble and undergo phase separation is critical for these functions bu...
A narrow ratio of nucleic acid to SARS-CoV-2 N-protein enables phase separation [0.03%]
适量的核糖核酸与SARS-CoV-2核蛋白可形成相分离现象
Patrick M Laughlin,Kimberly Young,Giovanni Gonzalez-Gutierrez et al.
Patrick M Laughlin et al.
SARS-CoV-2 Nucleocapsid protein (N) is a viral structural protein that packages the 30 kb genomic RNA inside virions and forms condensates within infected cells through liquid-liquid phase separation (LLPS). In both soluble and condensed fo...
A narrow ratio of nucleic acid to SARS-CoV-2 N-protein enables phase separation [0.03%]
适量的核糖核酸与SARS-CoV-2 N蛋白的比例可以实现相分离现象
Patrick M Laughlin,Kimberly Young,Giovanni Gonzalez-Gutierrez et al.
Patrick M Laughlin et al.
SARS-CoV-2 Nucleocapsid protein (N) is a viral structural protein that packages the 30kb genomic RNA inside virions and forms condensates within infected cells through liquid-liquid phase separation (LLPS). N, in both soluble and condensed ...
Intracellular Degradation of SARS-CoV-2 N-Protein Caused by Modular Nanotransporters Containing Anti-N-Protein Monobody and a Sequence That Recruits the Keap1 E3 Ligase [0.03%]
含有抗N蛋白单体和募集Keap1 E3连接酶序列的模块化纳米转运器引起的SARS-CoV-2 N蛋白的细胞内降解
Yuri V Khramtsov,Alexey V Ulasov,Tatiana N Lupanova et al.
Yuri V Khramtsov et al.
The proper viral assembly relies on both nucleic acids and structural viral proteins. Thus a biologically active agent that provides the degradation of one of these key proteins and/or destroys the viral factory could suppress viral replica...
SARS-CoV-2 N-protein induces the formation of composite α-synuclein/N-protein fibrils that transform into a strain of α-synuclein fibrils [0.03%]
SARS-CoV-2 N蛋白诱导形成α-突触核蛋白/N蛋白复合纤维，并转化为α-突触核蛋白原纤维的一种毒株
Slav A Semerdzhiev,Ine Segers-Nolten,Paul van der Schoot et al.
Slav A Semerdzhiev et al.
The presence of deposits of alpha-synuclein (αS) fibrils in the cells of the brain is a hallmark of several α-synucleinopathies, including Parkinson's disease. As most disease cases are not familial, it is likely that external factors pla...
Trace detection of SARS-CoV-2 N-protein by diamond solution-gate field-effect transistor [0.03%]
基于金刚石溶液门场效应晶体管的SARS-CoV-2 N蛋白超灵敏检测技术研究
Qianwen Zhang,Minghui Zhang,Yuxiang Du et al.
Qianwen Zhang et al.
In this study, we introduced H-terminated diamond solution-gate field-effect transistor (H-diamond SGFET) to detect trace SARS-CoV-2 N-protein, which plays an important role in replication and transcription of viral RNA. 1-Pyrenebutyric aci...
Electronic field effect detection of SARS-CoV-2 N-protein before the onset of symptoms [0.03%]
无症状期电子场效应检测SARS-CoV-2核蛋白
I Novodchuk,M Kayaharman,I Prassas et al.
I Novodchuk et al.
As part of the efforts to contain the pandemic, researchers around the world have raced to develop testing platforms to detect the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the Coronavirus disease 2019 (COVI...
Active site prediction of phosphorylated SARS-CoV-2 N-Protein using molecular simulation [0.03%]
基于分子模拟的磷酸化SARS-CoV-2 N蛋白活性位点预测
Sreenidhi Sankararaman,John Hamre rd,Fahad Almsned et al.
Sreenidhi Sankararaman et al.
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) nucleocapsid protein (N-protein) is responsible for viral replication by assisting in viral RNA synthesis and attaching the viral genome to the replicase-transcriptase complex...
Interactions between SARS-CoV-2 N-Protein and α-Synuclein Accelerate Amyloid Formation [0.03%]
SARS-CoV-2 N-蛋白与α-突触核蛋白的相互作用加速了类淀粉蛋白的形成
Slav A Semerdzhiev,Mohammad A A Fakhree,Ine Segers-Nolten et al.
Slav A Semerdzhiev et al.
First cases that point at a correlation between SARS-CoV-2 infections and the development of Parkinson's disease (PD) have been reported. Currently, it is unclear if there is also a direct causal link between these diseases. To obtain first...
Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids [0.03%]
SARS-CoV-2核蛋白与核酸共组装的构象和动力学特征
Huaying Zhao,Di Wu,Ai Nguyen et al.
Huaying Zhao et al.
Nucleocapsid (N) protein of the SARS-CoV-2 virus packages the viral genome into well-defined ribonucleoprotein particles, but the molecular pathway is still unclear. N-protein is dimeric and consists of two folded domains with nucleic acid ...
耗时 0.08876 秒，为您在
48229835
条记录里面共找到 11 篇文章 [XML]