Targeted inhibition of Ninjurin2 promotes chemosensitivity in chemoresistant gastric cancer by suppressing cancer-initiating cells [0.03%]
Ninjurin2靶向抑制通过抑制癌症起始细胞促进化学抗性胃癌的化疗敏感性
Hyo Shik Shin,Jae-Il Choi,Hye Won Chung et al.
Hyo Shik Shin et al.
Background: The combination of epirubicin, cisplatin, and 5-fluorouracil (ECF) is widely used for gastric cancer treatment. However, cancer cells can acquire chemoresistance over multiple treatment cycles, leading to recu...
Hepatocyte Ninjurin2 promotes hepatic stellate cell activation and liver fibrosis through the IGF1R/EGR1/PDGF-BB signaling pathway [0.03%]
肝细胞Ninjrin2通过IGF1R/EGR1/PDGF-BB信号通路促进肝星状细胞激活及肝纤维化
Yifan Wang,Pengyun Wang,Yubing Yu et al.
Yifan Wang et al.
Background: Liver fibrogenesis is orchestrated by the paracrine signaling interaction between several resident cell types regulating the activation of hepatic stellate cells (HSCs). However, the molecular mechanisms under...
Involvement of NINJ2 Protein in Inflammation and Blood-Brain Barrier Transmigration of Monocytes in Multiple Sclerosis [0.03%]
NINJ2蛋白在多发性硬化中单核细胞炎症及血脑屏障转位中的作用
Melissa Sorosina,Silvia Peroni,Elisabetta Mascia et al.
Melissa Sorosina et al.
Overall, our results suggest that ninjurin2 could be involved in the transmigration of immune cells into the CNS in pro-inflammatory conditions.
Spinal Ninjurin2 contributes to the neuropathic pain via NF-κB-mediated neuroinflammation in the spared sciatic nerve injury rats [0.03%]
脊髓NINJ2通过NF-κB介导的剩余坐骨神经损伤大鼠的感觉神经炎症参与神经痛产生
Hai-Ming Guo,Yu Zhang,Yan Zhang et al.
Hai-Ming Guo et al.
Object: Ninjurin2 (nerve injury induced protein 2, NINJ2) is a molecule which mediates cell-to-cell and cell-to-extracellular matrix interactions in the nervous system. Clinical study shows NINJ2 is associated with the de...
Li-Na Zhou,Ping Li,Shang Cai et al.
Li-Na Zhou et al.
Ninjurin2 (Ninj2) is an adhesion protein expressed in neurons and glial cells. The current study tested its expression and potential functions in human glioma. We show that Ninj2 mRNA and protein levels are significantly upregulated in huma...
Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide [0.03%]
丁烯酸四正辛酯活化Keap1-Nrf2信号通路保护神经元细胞免受过氧化氢的损伤
Hua Liu,Yu Feng,Min Xu et al.
Hua Liu et al.
Results: In SH-SY5Y neuronal cells and primary murine neurons, OI activated Nrf2 signaling, causing Keap1-Nrf2 disassociation, Nrf2 protein stabilization and nuclear translocation, as well as expression of Nrf2-regulated genes (HO1, NQO1 and GCLC) and ninjurin2 (Ninj2).
Association of serum Ninjurin2 levels with neurologic damage and postherpetic neuralgia occurrence: an observational cohort study in chinese herpeszoster patients [0.03%]
Ninjurin2蛋白血清水平与水痘-带状疱疹病毒感染神经损伤及后遗神经痛发生关系的观察型队列研究
Guozhuan Zhang,Yingjiao Sun,Lei Wang et al.
Guozhuan Zhang et al.
Objectives: Postherpetic neuralgia(PHN) is the most common complication of herpeszoster (HZ) infection. The study aimed to explore whether serum Ninjurin2 (for nerve injury-induced protein 2, NINJ2), a novel neurologic da...
Jingjing Wang,Jingjing Fa,Pengyun Wang et al.
Jingjing Wang et al.
Moreover, we found the expression of ninjurin2 is upregulated in LPS stimulated HUVECs and mouse aorta, and it can regulate LPS-induced endothelial activation and the adhesion of monocytes to endothelial cells. We also found that NINJ2 can regulate NF-κB and c-jun through interacting with TLR4....In conclusion, our study suggests that ninjurin2 is a novel regulator of endothelia inflammation and activation through TLR4 signaling pathways, and these data provided new insights into the mechanisms between NINJ2 and atherosclerosis.
Association between genetic variant on chromosome 12p13 and stroke survival and recurrence: a one year prospective study in Taiwan [0.03%]
位于第12号染色体短臂1区3带的基因变异与台湾地区一年期前瞻性缺血性脑卒中患者生存及复发的关系：一项为期一年的前瞻性研究
Yi-Chen Hsieh,Sudha Seshadri,Wen-Ting Chung et al.
Yi-Chen Hsieh et al.
These SNPs are close to the ninjurin2 gene which may alter the risk of stroke by affecting brain response to ischemic injury.
Multicenter Study
Journal of biomedical science. 2012 Jan 3;19(1):1. DOI:10.1186/1423-0127-19-1 2012
Genetic polymorphisms of a novel vascular susceptibility gene, Ninjurin2 (NINJ2), are associated with a decreased risk of Alzheimer's disease [0.03%]
新颖的血管易感基因NINJ2的遗传多态性与阿尔茨海默病发病风险降低有关
Kun-Pei Lin,Shih-Yuan Chen,Liang-Chuan Lai et al.
Kun-Pei Lin et al.
Background: Accumulated evidences have shown that vascular risk factors, e.g., hypertension, diabetes mellitus and hyperlipidemia, may be related to the risk of dementia. This study investigated the association between ge...
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