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Cell communication and signaling : CCS. 2018 Nov 15;16(1):81. doi: 10.1186/s12964-018-0294-2 Q18.92025

Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide

丁烯酸四正辛酯活化Keap1-Nrf2信号通路保护神经元细胞免受过氧化氢的损伤 翻译改进

Hua Liu  1, Yu Feng  2, Min Xu  3, Jian Yang  1, Zhichun Wang  4, Guangfu Di  5

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作者单位

  • 1 Department of Neurosurgery, The First People's Hospital of Kunshan, Jiangsu University, Suzhou, China.
  • 2 Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
  • 3 Department of Neurosurgery, Kunshan Hospital of Traditional Chinese Medicine, Kunshan Affiliated Hospital, Suzhou, China.
  • 4 Department of Neurosurgery, Yijishan Hospital, Wannan Medical College, Wuhu, China.
  • 5 Department of Neurosurgery, Yijishan Hospital, Wannan Medical College, Wuhu, China. wuhusjwk@163.com.

    • DOI: 10.1186/s12964-018-0294-2 PMID: 30442144

    摘要 Ai翻译

    Background: Four-octyl itaconate (OI), the itaconate's cell-permeable derivative, can activate Nrf2 signaling via alkylation of Keap1 at its cysteine residues. The current study tested the potential neuroprotective function of OI in hydrogen peroxide (H2O2)-treated neuronal cells. Methods: SH-SY5Y neuronal cells and epigenetically de-repress... ...点击完成人机验证后继续浏览
    Copyright © Cell communication and signaling : CCS. 中文内容为AI机器翻译，仅供参考！

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    期刊名：Cell communication and signaling

    缩写：CELL COMMUN SIGNAL

    ISSN：N/A

    e-ISSN：1478-811X

    IF/分区：8.9/Q1

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    Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide