Pinched-flow fractionation-based extracellular vesicle isolation by ExoFAST and its analytical benchmarking with commercial technologies [0.03%]
基于ExoFAST的挤压流动分离衍生的外泌体分离及其与商业技术的分析基准测定
Chaithanya Chelakkot,Yanymee N Guillen-Quispe,Jongjin Jo et al.
Chaithanya Chelakkot et al.
The growing interest in liquid biopsy biomarkers for non-invasive diagnostic approaches has spot-lighted extracellular vesicles (EVs), particularly exosomes, as promising candidates.
Self-protected circular DNAzyme for integrated enrichment and quantification of small extracellular vesicles [0.03%]
自我保护的环状DNA酶，用于小型细胞外囊泡的集成富集和定量检测
Qianqian Wu,Yican Li,Ruyan Niu et al.
Qianqian Wu et al.
Small extracellular vesicles (sEVs) hold immense potential for liquid biopsy given the wealth of biological information they carry. Currently, the clinical application of these methods is limited due to their low abundance and the complexities associated with traditional isolation techniques.
ctDNA guided management of POLE mutant GI malignancies promotes exceptional responses and prolonged survival to immunotherapy [0.03%]
基于ctDNA的POLE突变型GI恶性肿瘤管理可促进免疫治疗的优异反应和长期生存期延长
Umair Mahmood,Chetan Bhan,Charles Imber et al.
Umair Mahmood et al.
We highlight the utility of a liquid biopsy approach to aid selection of GI cancer patients harbouring rare POLE mutations for immunotherapy, leading to complete metabolic response in addition to radiologic responses and extended survival in all three patients.
MSMO1 promotes chemotherapy resistance through modulation of T-MAS metabolism via PERK/elF2α/ATF4/CHOP pathway [0.03%]
MSMO1通过PERK/elF2α/ATF4/CHOP途径调节T-MAS代谢促进化疗耐药性
Hengyu Ren,Xuliren Wang,Zhibo Shao et al.
Hengyu Ren et al.
Our study introduces a noninvasive liquid biopsy approach, utilizing exosomes to reflect the metabolic profile of primary tumors at the transcriptome level.
Unveiling miR-451a and miR-142-3p as prognostic markers in non-small cell lung cancer via small extracellular vesicle liquid biopsy [0.03%]
通过小型细胞外囊泡液体活检在非小细胞肺癌中揭示范miR-451a和miR-142-3p作为预后标志物的作用
Miranda Burdiel,Ana Arauzo-Cabrera,Julia Jiménez et al.
Miranda Burdiel et al.
Multi-omics biomarker detection in Diethylnitrosamine (DENA) induced hepatocellular carcinoma [0.03%]
N-亚硝基二乙胺诱导的肝细胞癌多组学生物标志物检测
Obaid Afzal,Pavan Goud,Kavita Goyal et al.
Obaid Afzal et al.
This review summarizes multi-omics data from DENA models and translational cohorts, encompassing genomics/epigenomics, transcriptomics, proteomics, metabolomics, and glycomics, as well as liquid biopsy analytes, including cell-free DNA, extracellular vesicle cargo, and circulating tumor cell markers.
Saliva liquid biopsy: MMP2, MMP9, and TIMP2 as potential diagnostic biomarkers in oral squamous cell carcinoma. An observational case-control study [0.03%]
唾液液体活检：金属基质蛋白酶MMP2、MMP9及其抑制物TIMP2作为口腔鳞状细胞癌潜在诊断生物标志物的病例对照观察研究
Sergio D Cruz-Romero,Ana Margarita Baldión,José Antonio Hakim Tawil et al.
Sergio D Cruz-Romero et al.
Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm in the oral cavity, characterized by high morbidity and mortality. Various proteins, including matrix metalloproteinases (MMPs), have been investigated as potential b...
Detection of plasma EV-associated TRAIL by nanoscale flow cytometry for liver metastasis prediction in PDAC [0.03%]
通过纳米级流式细胞术检测血浆EV相关的TRAIL以预测PDAC肝转移
Chun-Xiang Huang,Jia-Hong Jian,Jun-Sheng Hao et al.
Chun-Xiang Huang et al.
Extracellular vesicles (EVs) mediate tumor-host communication and represent a promising liquid biopsy source for metastasis risk assessment, yet quantitative detection of low-abundance, epitope-defined EV subpopulations in plasma remains technically challenging.
Small Extracellular Vesicles in Gestational Diabetes Mellitus: Current Landscape and Emerging Diagnostic Horizons [0.03%]
妊娠期糖尿病中小细胞外囊泡的现状和新兴诊断前景
Mai Ahmed,Dada Oluwaseyi Temilola,Mushi Matjila et al.
Mai Ahmed et al.
Small extracellular vesicles (sEVs) nanosized vesicles released by maternal, placental, and adipose tissues have emerged as promising candidates for liquid biopsy approaches in GDM.
Visualizing extracellular vesicles in cancer: from biogenesis to theranostic applications [0.03%]
癌症中外泌体的可视化：从发生机制到诊疗应用
Deqiang Deng,Lili Wang,Zhen Zeng et al.
Deqiang Deng et al.
Finally, we discuss the integration of these imaging technologies with therapeutic strategies, highlighting the transition of EVs from biological entities to engineered nanomedicines for liquid biopsy and targeted delivery.
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