A Dual-Activated Catalytic Hairpin Assembly Signal Amplification Nanoplatform for High-Sensitivity Detection of Dual-Target MicroRNAs [0.03%]
YanYan Ma,Mingzhen Yang,Jiali Zheng et al.
YanYan Ma et al.
Early diagnosis of hepatocellular carcinoma is crucial for improving patient prognosis, and microRNA (miRNA) detection via liquid biopsy is important.
Harnessing exosomes for biomarker development and therapy in hepatitis virus infection [0.03%]
外泌体在肝炎病毒感染生物标志物开发和治疗中的应用
Kurbaniyazova Madina Zafarjanovna,Alidjanova Lazizakhon Abbasovna,Toshov Hayot Muhammadovich et al.
Kurbaniyazova Madina Zafarjanovna et al.
This narrative review synthesizes current evidence on the dual role of exosomes in hepatitis virus infection, evaluating their evolution from pathogenic vectors to clinical tools for liquid biopsy diagnostics and engineered antiviral delivery.
Liquid Biopsy in Modern Oncology: Advances, Challenges, and Future Perspectives in Early Cancer Detection, Minimal Residual Disease, and Dynamic Patient Monitoring [0.03%]
液体活检在现代肿瘤学中的应用：早期癌症检测、微小残留病灶以及动态患者监测方面的进展、挑战和未来前景
Yareli Lizbeth Rojas-Salazar,Emiliano Gómez-Montañez,Jorge Gustavo Rojas-Salazar
Yareli Lizbeth Rojas-Salazar
Purpose of review: Liquid biopsy has emerged as a minimally invasive approach to overcome the limitations of tissue biopsy in oncology. This review aims to synthesize recent advances in its clinical applications, particul...
Somatic mutation profiling by NGS-based liquid biopsy in advanced non-small cell lung cancer: frequency, clinical correlates, and prognostic significance [0.03%]
基于NGS的液体活检在晚期非小细胞肺癌中的体细胞突变检测：发生率，临床相关性及预后价值分析
Çağrı Doğan,Cengiz Akosman,Müge Sönmez et al.
Çağrı Doğan et al.
Conclusions: NGS-based liquid biopsy identified actionable and resistance-associated mutations in 25% of advanced NSCLC patients in this Turkish Black Sea cohort. Total cfDNA concentration correlated with metastatic burden.
Development and validation of a multiplexed targeted HILIC-HRMS assay for quantitative analysis of hepatocellular carcinoma circulating biomarkers [0.03%]
一种用于定量分析肝细胞癌循环生物标志物的多重靶向亲水作用色谱高分辨质谱测定法的开发与验证
Danila La Gioia,Vicky Caponigro,Anna Lucia Tornesello et al.
Danila La Gioia et al.
The developed targeted approach demonstrated a promising potential tool for HCC discrimination from other liver diseases, and, by obtaining quantitative values of circulating analytes, could serve as a liquid biopsy approach for early diagnostics and therapy evaluation.
Molecular features unique to circulating tumor DNA enable the tumor-naïve liquid biopsy of glioblastoma [0.03%]
循环肿瘤DNA的分子特征可实现对胶质母细胞瘤的无病期液体活检
Hunter R Underhill,Drew L Sellers,Sabine Hellwig et al.
Hunter R Underhill et al.
Glioblastoma is the most common and deadly brain cancer in adults. Although the disease disrupts the blood-brain barrier and exposes the tumor to the systemic circulation, using circulating cell-free DNA as a non-invasive biomarker for diag...
The miR4261/PAMM axis in multiple myeloma promotes bone resorption [0.03%]
miR4261/PAMM轴在多发性骨髓瘤中促进骨吸收
Jiangxia Cui,Sicheng Bian,Zhuanghui Hao et al.
Jiangxia Cui et al.
This study investigates the mechanisms underlying myeloma bone disease (MBD) in multiple myeloma (MM), focusing on myeloma cell-derived exosomes and liquid biopsy biomarkers to identify therapeutic targets for reducing osteoclast activity and enhancing bone homeostasis.
Study on NGS-based molecular profiling of malignant pleural effusion supernatant cfDNA in guiding targeted therapy for non-small cell lung cancer [0.03%]
基于NGS的恶性胸水上清游离DNA分子分型指导非小细胞肺癌精准治疗的研究
Yuan Wang,Shuo Liang,Jia-Meng Zhang et al.
Yuan Wang et al.
Background: For patients with advanced non-small cell lung cancer (NSCLC), obtaining histological specimens can be challenging due to the presence of malignant pleural effusion (MPE), making liquid biopsy an important alternative for molecular profiling.
Single-nucleotide variant profiling in liquid biopsy with RECO-Cas [0.03%]
基于RECO-Cas的液态活检单核苷酸变异体分析方法
Chong Guo,Shuo Zhang,Ramachandra Yerramsetti et al.
Chong Guo et al.
Mutation detection of cell-free DNA (cfDNA) through liquid biopsy is essential for precision oncology, resistance profiling, and informed clinical decision-making. However, its clinical application has remained limited by the lack of simple, rapid, accurate, and cost-effective detection approaches.
Methylated circulating tumor DNA: technical challenges and clinical applications in non-small cell lung cancer patients-a narrative review [0.03%]
血甲基化循环肿瘤DNA的技术挑战及在非小细胞肺癌患者中的临床应用-综述文章
Manon Robert,Chloé Sauzay,Sandrine Théoleyre et al.
Manon Robert et al.
Circulating tumor DNA (ctDNA) obtained through liquid biopsy enables non-invasive tumor profiling. While most applications rely on mutation detection, DNA methylation of ctDNA (Met-ctDNA) represents a promising complementary approach.
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