From Tissue Archives to Liquid Biopsy: Transfer Learning for MicroRNA-Based Lung Cancer Diagnosis [0.03%]
Jiajia Song,Ruiting Liu,Yixuan Wu et al.
Jiajia Song et al.
Serum microRNA-based liquid biopsy holds a great application prospect in noninvasive lung cancer diagnosis....We envision that the approach offers a cost-effective solution for high-accuracy liquid biopsy with limited samples.
Noninvasive enrichment of circulating tumor biomarkers in a mouse model of diffuse midline glioma using focused ultrasound [0.03%]
Dingyue Zhang,Yimei Yue,Yan Gong et al.
Dingyue Zhang et al.
Results: FUS enhanced the plasma levels of EGFP ctRNA by 5.4-fold (p=0.0112), compared with liquid biopsy without FUS. CSF EGFP ctDNA was increased by 2.5-fold (p=0.0253), and Fluc ctDNA was increased by 2.6-fold (p=0.0253) with FUS....However, the effectiveness of liquid biopsy is hindered by its low sensitivity and the lack of information about the source of biomarkers....This study opens new avenues for advancing noninvasive DMG diagnosis through FUS-enhanced liquid biopsy (sonobiopsy).
Domingos Roda,Filipa Oliveira,Pedro Veiga et al.
Domingos Roda et al.
Starting on the day of surgery, a liquid biopsy was employed to assess the dynamic alterations in cell-free DNA (cfDNA). Upon recurrence, reoperation was conducted, and repeated radiochemotherapy was applied.
Intrapatient variation in PD-L1 expression and tumor mutational burden and implications for outcomes to immune checkpoint inhibitor therapy in patients with non-small-cell lung cancer [0.03%]
程序性死亡配体1表达和肿瘤突变负荷的院内变异及其对非小细胞肺癌患者免疫检查点抑制剂治疗结果的影响
Gege Li,Jiashuai Xu,Xiaohan Tian et al.
Gege Li et al.
Furthermore, we highlight the need for more rigorous patient stratification in future studies and suggest that dynamic monitoring tools like liquid biopsy could enhance clinical decision-making.
[Therapy-Associated Neuroendocrine Prostate Cancer (tNEPC): A Diagnostic and Therapeutic Challenge in Uro-Oncology with Emerging Clinical Implications] [0.03%]
[与治疗相关的神经内分泌前列腺癌(tNEPC):泌尿系统肿瘤学中具有新兴临床意义的诊断和治疗挑战]
Gunhild von Amsberg,Arndt Hartmann,Markus Eckstein et al.
Gunhild von Amsberg et al.
Immunohistochemical diagnosis relies on the detection of markers such as synaptophysin, chromogranin A, CD56, and INSM1.In addition to histology, [¹⁸F]-FDG and DOTA-based PET/CT imaging modalities, as well as emerging liquid biopsy approaches (e.g., circulating tumour cells, cfDNA methylation), are increasingly
Circulating cellular communication network factor 1 (CCN1) as a liquid biopsy marker indicating progression in advanced melanoma [0.03%]
循环细胞通讯网络因子1(CCN1)作为提示晚期黑色素瘤进展的液体活检标志物
Isabel Heidrich,Kim-Lea Reese,Helen Ullemeyer et al.
Isabel Heidrich et al.
Sputum proteomics and phosphoproteomics for improving chronic obstructive pulmonary disease knowledge [0.03%]
支气管炎蛋白组和磷酸化蛋白质组学以提高慢性阻塞性肺病的认识
Fei Long,Xiaoyin Zeng,Fengyan Wang et al.
Fei Long et al.
Our study is the first to demonstrate that raw induced sputum can serve as a viable alternative source for liquid biopsy in respiratory diseases.
Emerging clinical applications of exosomes in breast cancer management from biomarkers to therapeutics [0.03%]
外泌体在乳腺癌诊疗中的新兴临床应用:从生物标志物到治疗靶点
Xiangmei Wu,Wenjing Wang
Xiangmei Wu
Growing evidence supports the diagnostic utility of TDEs in early detection and molecular subtyping of breast cancer, particularly via non-invasive liquid biopsy approaches.
[Liquid biopsy proteomics in ophthalmology : A clinical and scientific perspective] [0.03%]
[眼科液体活检蛋白组学的临床和科学视角]
Marius Ueffing,Clemens Lange,Günther Schlunck et al.
Marius Ueffing et al.
Objective: A clinical and scientific perspective with respect to potential fields of applications of liquid biopsy proteomics in ophthalmology is presented.
Paraneoplastic Neurological Syndromes: Advances and Future Perspectives in Immunopathogenesis and Management [0.03%]
肿瘤相关神经系统综合征:免疫病理机制及治疗策略的研究进展与未来趋势
Stoimen Dimitrov,Mihael Tsalta-Mladenov,Plamena Kabakchieva et al.
Stoimen Dimitrov et al.
Newly described antibodies and methodological innovations such as PhIP-Seq, neurofilament light chain, and liquid biopsy are highlighted, which refine tumor search strategies and longitudinal monitoring.
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