Heidi Pharo,Hege Marie Vedeld,Ingrid Vikan Sjurgard et al. Heidi Pharo et al.

This review addresses key aspects influencing successful biomarker development and clinical implementation-including liquid biopsy source selection, biomarker discovery workflow and targeted validation in clinical sample series-and provide strategies to improve accuracy, reproducibility and clinical...Altogether, these considerations could aid in bridging the translational gap from research to clinical application, and to increase the number of clinically implemented liquid biopsy tests. © 2025. The Author(s).

A Tarabay,L Swales,C Smolenschi et al. A Tarabay et al.

Results: Among 342 patients (median age 61 years; 48% female; 95% Eastern Cooperative Oncology Group 0-1), molecular profiling was carried out using tissue (50%), liquid biopsy (45%), or both (5%). The most common gene alterations were KRAS (84%), TP53 (72%), and CDKN2A (26%).

Adriana Payan-Medina,Victor R Putaturo,Sajad R Bazaz et al. Adriana Payan-Medina et al.

The capability to deterministically and precisely control the lateral position of focused cell streams in a microchannel provides diverse opportunities for biomedical applications, including cell concentration, imaging flow cytometry, and cell-based liquid biopsy platforms.

Hisashi Ro,Shun Ishiyama,Kiichi Sugimoto et al. Hisashi Ro et al.

The integration of multi-targeted therapies and liquid biopsy technologies represents a critical step toward precision oncology.

Moazzam Shahzad,Muhammad Kashif Amin,Nouman Aziz et al. Moazzam Shahzad et al.

This review explores how liquid biopsy may influence HRQoL outcomes across various cancer types. A comprehensive literature search identified four studies that collectively included 2541 patients. The findings suggest a favorable impact on both emotional and functional well-being....Overall, liquid biopsy shows promise in enhancing HRQoL by supporting personalized care and reducing emotional burden.

Shohei Komine,Akihiko Iwase Shohei Komine

We present 2 cases of patients with Trousseau syndrome who were diagnosed with lung cancer using liquid biopsy and document their long-term survival following tyrosine kinase inhibitor treatment.

Azra Yasmin,Ritesh Jha,Aarti Passi et al. Azra Yasmin et al.

Particular emphasis is placed on genetic, epigenetic, proteomic, and metabolomic markers, as well as liquid biopsy derived components such as ctDNA methylation, exosomal RNA, and extracellular vesicle biomarkers.

Mona Mlika,Mohamed Majdi Zorgati,Imen Ben Ismail et al. Mona Mlika et al.

Introduction: The utility of liquid biopsy in the screening and the follow-up of many cancers and mainly CRC has been reported by many authors....Results: Our results revealed a high diagnostic potential of the liquid biopsy in CRC with a pooled SEN, SPE, PLR, NLR and DOR accounting respectively for 77%, 94.3%, 6.85, 0.26 and 26.467. The AUC accounted for 0.97....Plain language summary Many researchers have looked into using liquid biopsy as a way to detect and monitor different types of cancer, especially colon cancer....In this study, we wanted to see how well liquid biopsy could work compared to the more traditional method, which involves taking a sample of the tumor directly.To do this, we gathered and analyzed results from a number of previous studies....We found that liquid biopsy seems to work well for detecting colon cancer. However, there was quite a bit of variation between the different studies.

Issei Saeki,Yutaka Suehiro,Yurika Yamauchi et al. Issei Saeki et al.

We previously reported the usefulness of a liquid biopsy test based on a sensitive methylated septin 9 (m-SEPT9) assay for detecting HCC.

Xian Li,Weiwei Zhang,Yalan Chen et al. Xian Li et al.

positivity and specificity in early-stage GC; therefore, actively identifying novel molecules for combined diagnosis in conjunction with traditional biomarkers proves essential for the early diagnosis of GC. tRNA-derived small RNAs (tsRNAs), a novel category of non-coding RNAs (ncRNAs), exhibit promise as liquid...biopsy indicators and can engage in the pathological processes of cancer through diverse molecular pathways.