Abdullah Al-Khanaty,David Hennes,Michael S Hofman et al.
Abdullah Al-Khanaty et al.
The role of prostate biopsy in early detection is increasingly being questioned in the era of advanced imaging. With the widespread adoption of multiparametric magnetic resonance imaging and the emergence of prostate-specific membrane antig...
Progress in the application of combined detection of urinary tumor DNA and exosomes in the classification, staging, and clinical management of bladder cancer: a review [0.03%]
尿液肿瘤DNA和外泌体联合检测在膀胱癌分类、分期及临床管理中的应用进展：综述
Mengyun Wang,Jianchuan Chen,Cheng Wang et al.
Mengyun Wang et al.
Recent advances in liquid biopsy have highlighted the potential of urinary tumor DNA (utDNA) and exosomes as non-invasive biomarkers for diagnosis, molecular classification, staging, and therapeutic monitoring. utDNA reflects the genomic and epigenetic alterations of BC with high concordance to tumor...Future research integrating multi-omics profiling and artificial intelligence is expected to establish urinary liquid biopsy as a key tool for precision medicine in BC management.
Flow-cytometric profiling of large extracellular vesicles as immunophenotypic biomarkers in head and neck squamous cell carcinoma [0.03%]
头颈鳞状细胞癌中作为免疫表型生物标志物的大胞外囊泡的流式细胞术分析
Judith Büntzel,Markus Maulhardt,Alexander Casimir Angleitner et al.
Judith Büntzel et al.
Conclusion: Flow-cytometric profiling of circulating large EV provides a feasible liquid biopsy approach for tumor characterization in HNSCC.
[Liquid biopsy empowers precision medicine across the full course of bladder cancer] [0.03%]
[液体活检赋能膀胱癌全程精准治疗]
W L Zhong,H R Zheng,T X Lin
W L Zhong
By analyzing tumor-derived cells and molecular information in urine or blood, liquid biopsy provides an important complementary approach for precision management of bladder cancer across the disease course....Owing to the direct contact between bladder tumors and urine, urine-based liquid biopsy is more suitable for screening, adjunctive diagnosis, and intravesical recurrence monitoring....In contrast, blood-based liquid biopsy better reflects systemic tumor biology and has potential value in perioperative adjuvant treatment decision-making and treatment response monitoring....Nevertheless, the clinical translation of liquid biopsy still faces challenges, including insufficient sample standardization, heterogeneous detection systems, and relatively high costs.
Using Gene Expression Changes for Monitoring Glioblastoma WHO CNS Grade 4 Recurrence: Validation of NGS Candidate Genes via qRT-PCR [0.03%]
通过qRT-PCR验证NGS候选基因以实现对IV级胶质母细胞瘤复发进行基因表达变化监测
R Muhtadi,N Schmid,D Bernhardt et al.
R Muhtadi et al.
Our findings may point to the possible utility of gene expression measurements in peripheral whole blood as a simplified liquid biopsy method for GBM tumor recurrence.
Emerging biomarkers for the early detection of high-grade serous tubo-ovarian cancer [0.03%]
高级别浆液性输卵管卵巢癌早期诊断的新兴生物标志物
Sara Atiq,Nikola A Bowden,Kristina Warton et al.
Sara Atiq et al.
While there are no biomarkers that have been approved for population-wide screening, evidence strongly supports DNA methylation-based liquid biopsy approaches for screening and early detection of high-grade serous tubo-ovarian cancer.
Detection of Ultralow-Frequency ctDNA Mutations Using a Dual Hairpin-Competition CRISPR/Cas14a System [0.03%]
利用双发夹竞争型CRISPR/Cas14a系统检测超低频ctDNA突变
Zhaocheng Liu,Rui Zhang,Chunyan Chang et al.
Zhaocheng Liu et al.
By combining ultrahigh sensitivity, PAM independence, multiplexing preamplification capability, and practical affordability, DHCC provides an accessible platform for ctDNA-based liquid biopsy in clinical settings.
Sputum Liquid Biopsy for Lung Cancer Screening, Diagnosis, Subtyping, Surveillance, Response Prediction, and Prognostication: A Scoping Review [0.03%]
肺癌筛查、诊断、分型、监测、疗效预测和预后评估的痰液液体活检：系统综述
Abdul Rehman,Muhammad Awais,Hafiza Noor Ul Ain Baloch et al.
Abdul Rehman et al.
Background/Objectives: Liquid biopsy (LB) is transforming cancer care by enabling minimally invasive tumor profiling. While current research and clinical pathways mostly focus on blood LB, sputum represents a non-invasive, readily available...
Transitioning from invasive to liquid biopsy techniques: a bibliometric analysis and prospective insights on biomarkers in lupus nephritis [0.03%]
从有创到无创的生物标志物研究技术转变：系统性红斑狼疮肾炎生物标志物的文献计量分析及展望
Chen Liu,Yanhao Chen,Xiang Li et al.
Chen Liu et al.
Background: Lupus nephritis (LN) significantly contributes to morbidity and mortality in systemic lupus erythematosus (SLE) patients. Although renal biopsy is the diagnostic "gold standard," its invasiveness limits ongoin...
Sima Singh,Ada Raucci,Antonella Miglione et al.
Sima Singh et al.
Unlike tissue biopsy, which captures only a single tumor region at one moment, liquid biopsy enables repeated, minimally invasive sampling that reflects the molecular state of disease across all lesions.
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