Zi-Zhan Li,Li-Ya Wei,Lei-Ming Cao et al. Zi-Zhan Li et al.

This review systematically examines the expanding roles of microfluidics in oral cancer research, with a particular focus on microfluidics-based liquid biopsy for early detection and prognosis, and microfluidics-enabled therapeutic strategies for treatment development and optimization.

Sunita Ahlawat,Sumanta Das Sunita Ahlawat

Looking forward, the integration of artificial intelligence, liquid biopsy approaches, and real-time molecular monitoring promises to enable dynamic, multi-dimensional tumor characterization.

Claire R Kissinger,Devin J Miller,Zhenteng Li et al. Claire R Kissinger et al.

While the liquid biopsy and ablation of one of the lesions confirmed the diagnosis, the liquid biopsy was a key first step that provided a comprehensive diagnostic and prognostic picture without the need for an invasive procedure....This case highlights how integrating liquid biopsy into the diagnostic pathway for uveal melanoma can lead to earlier, more informed treatment decisions.

William Y Shi,Kevin J Liu,Mohammad S Esfahani et al. William Y Shi et al.

These findings highlight the potential of field-effect-informed liquid biopsy methods for guiding personalized therapy and uncovering biomarkers for individual components of multimodal treatments.

Duo Liu,Jie Yu,Jingxue Li et al. Duo Liu et al.

Biomimetic membrane interface engineering constructs functionalized detection platforms by incorporating natural cell membranes, synthetic lipids, or hybrid membranes. The primary purpose of this strategy is to minimize background interfere...

Gurpreet Singh,Ram Sharma,Vinod Gautam et al. Gurpreet Singh et al.

Future research aims to improve patient selection through biomarkers like replication-stress signatures, RAD51 foci tests, and liquid biopsy DNA damage markers; develop advanced modalities including brain-penetrant scaffolds, PROTAC degraders, and dual ATR/PARP or ATR/HDAC inhibitors; and optimize intermittent

Rayane da Silva Abreu,Danielle Dias Pinto Ferreira,Natassia Silva de Araujo et al. Rayane da Silva Abreu et al.

Unlike traditional tissue biopsies, which are invasive and limited by tumor accessibility and sampling bias, liquid biopsy enables real-time tumor assessment through the analysis of circulating biomarkers in blood and other biofluids....We also discuss state-of-the-art methodologies, including next-generation sequencing, digital PCR, microfluidics, proteomics, and emerging artificial intelligence-based approaches that enhance the sensitivity, specificity, and scalability of liquid biopsy assays....Clinical studies demonstrate the potential of liquid biopsy for tailoring targeted therapies, predicting resistance mechanisms, and identifying tumor recurrence earlier than conventional methods....Disparities in access, particularly between high-income and low- and middle-income countries, underscore the need for strategies that ensure equitable adoption of liquid biopsy technologies worldwide....In summary, liquid biopsy represents a paradigm shift in oncology, bridging innovations in cancer diagnostics with clinical applications.

Min Gao,Pei-Yan Yu,Run-Xuan Li et al. Min Gao et al.

Circulating tumor DNA (ctDNA), comprising DNA fragments released by cancer cells into the bloodstream, can be detected using liquid biopsy technology.

Marianna Rita Brogna,Gerardo Ferrara,Valeria Varone et al. Marianna Rita Brogna et al.

With the advancements in precision oncology, liquid biopsy has emerged as a promising, non-invasive tool for diagnosing TNBC, predicting prognosis, and monitoring treatment response....Despite these promising developments, significant challenges persist in the standardization and clinical implementation of liquid biopsy techniques....This review provides a comprehensive overview of the current and future applications of liquid biopsy in TNBC management, highlighting its potential to improve early disease detection, optimize therapeutic strategies, and refine patient classification....Integrating liquid biopsy into routine clinical practice could lead to better treatment outcomes and more personalized approaches to TNBC care.

Ming Chen,Mingjun Zhao,Yue Cai et al. Ming Chen et al.

Using liquid biopsy with rich metabolic information, SERS has facilitated the identification, analysis, and progression monitoring of various cancers. In this review, we systematically summarize recent advances in label-free SERS-based cancer diagnostics....We then highlight the applications of label-free SERS in liquid biopsy using various biofluids, including blood, urine, saliva, and sweat.