Lung-only metastatic pancreatic cancer: Differences in patients 'characteristics, molecular profile and survival [0.03%]
Alice Boilève,Léa Mercier,Baptiste Bonnet et al.
Alice Boilève et al.
patients were more frequently female (63 % vs. 46 %), older at metastatic diagnosis (median 66 vs. 63 years, p = 0.01), and less likely to have synchronous metastases (42 % vs. 69 %, p < 0.001). ctDNA detection was lower in the lung-only group with less KRAS mutations and TP53 mutations detected with liquid...biopsy (but no difference was observed using tumor tissue).
A machine learning-driven Raman spectroscopy approach for non-invasive diagnosis of non-puerperal mastitis [0.03%]
Yongqi Li,Haoran Zhang,Yining Jia et al.
Yongqi Li et al.
Nevertheless, novel approaches for the detection and analysis of PBMCs remain urgently needed to facilitate the development of liquid biopsy strategies....Our findings indicate that PBMC-based liquid biopsy coupled with Raman spectroscopy and machine learning provides novel opportunities for the diagnosis of NPM.
Sophia M Abusamra,Thineskrishna Anbarasan,Daniele T Cotton et al.
Sophia M Abusamra et al.
CTC sampling offers a liquid biopsy method to achieve minimally invasive longitudinal sampling for disease monitoring. CTC analysis has also offered a crucial insight into aggressive phenotypes, disease metastasis and treatment response, particularly in clinical trials.
Integrative multiomic profiling of cfDNA methylation and EV-miRNAs identifies immunotherapy-outcome molecular subtypes in NSCLC [0.03%]
Juan Luis Onieva,Elisabeth Pérez-Ruiz,Laura Cristina Figueroa-Ortiz et al.
Juan Luis Onieva et al.
Methods: In a prospective cohort study, we longitudinally assessed liquid biopsy samples from patients with NSCLC undergoing IT at four distinct time points (T1 pretreatment, T2 post-second cycle, T3 6 months, and T4 1 year).
Surface Marker Identification to Capture Live Circulating Tumor Cells in Metastatic Triple-Negative Breast Cancer [0.03%]
Bree M Lege,Khushali J Patel,Brendan Panici et al.
Bree M Lege et al.
The use of these newly identified CTC markers significantly enhances both detection and live capture of CTCs, paving the way for more effective use of liquid biopsy to monitor patient prognosis and treatment response in clinical settings.
Clinical Significance for risk stratification of papillary thyroid cancer by TUMORFISHER circulating tumor cells technique [0.03%]
Liehao Jiang,Xuejie Li,Tianyi Ma et al.
Liehao Jiang et al.
This study aimed to evaluate the effectiveness of using circulating tumor cells (CTCs) as a non-invasive liquid biopsy tool to stratify patient risk preoperatively....This liquid biopsy approach allows clinicians to personalize therapy-confidently selecting conservative management for low-risk individuals and recommending aggressive treatment for high-risk patients-thereby optimizing clinical decision-making and long-term outcomes.
Tatsusnori Shimoi,Shosuke Kita,Kan Yonemori
Tatsusnori Shimoi
Over the next five years, earlier CGP use, broader RNA-enabled diagnostics, and trial-mediated access to targeted agents should expand; coupling liquid biopsy with multi-omics and AI will refine classification and treatment selection.
A bird's eye view on potential molecular prognostic markers in retinoblastoma: insights for precision oncology [0.03%]
Irene Titin Darajati,Eddy Supriyadi,Petrus Gandi Purwosatrio et al.
Irene Titin Darajati et al.
The integration of AH liquid biopsy in RB management may aid prognosis prediction and optimize treatment strategies.
General practitioners' attitudes towards liquid biopsy as a diagnostic test for advanced lung cancer [0.03%]
全科医生对液体活检作为肺癌诊断检测的态度
Danyon Lo,Jenny Wong,Rawiri Keenan et al.
Danyon Lo et al.
Testing as a liquid biopsy could be more accessible, faster, and lower cost compared to tissue biopsy.We aimed to evaluate NZ General Practitioners' (GPs') attitudes towards liquid biopsy....Some GPs highlighted the potential of liquid biopsy to complement existing procedures particularly in rural areas although concerns were expressed regarding culturally appropriate pathways....Provided adequate training and funding for liquid biopsy, 42/58 (72 %) of GPs stated they would be comfortable requesting liquid biopsy and the associated counselling....Conclusion: Most GPs were not familiar with liquid biopsy but 72 % supported these tests to be incorporated into current pathways.
Circulating tumour DNA (ctDNA) as a predictor of progression-free and overall survival in non-resectable pancreatic cancer: a systematic review and meta-analysis [0.03%]
循环肿瘤DNA(ctDNA)在不可切除胰腺癌患者中无进展生存和总生存的预后价值：系统评价和Meta分析
Mette M Steiniche,Louise B Callesen,Elizabeth H Vlk et al.
Mette M Steiniche et al.
Background: This systematic review and meta-analysis synthesised current evidence on circulating tumour DNA (ctDNA) for predicting clinical outcomes in patients with non-resectable pancreatic ductal adenocarcinoma (PDAC)....
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