Angiotensin-Neprilysin Inhibition and Left Ventricular Assist Device Therapy -Primary results of the multicENter, randomized, open-label, parallel group, study to evaluate the use of sacubitril/valsartan in HeartMate 3 LVAD recipients (ENVAD-HF) [0.03%]
血管紧张素-中性肽酶抑制与左心室辅助装置治疗-多中心随机开放标签行对照平行组研究：评估沙库巴曲缬沙坦在HeartMate 3左心室辅助装置植入患者中的应用（ENVAD-HF研究）主要结果
Maja Cikes,Jasper J Brugts,Brian Claggett et al.
Maja Cikes et al.
Background: The role of heart failure specific therapies in LVAD recipients is unclear and observational data suggest improved outcomes with neurohormonal blockers. ENVAD-HF evaluated safety and tolerability of the Angiot...
Gender-Dependent Cognitive and Metabolic Benefits Due to Glyoxalase 1 (Glo1) Overexpression in Age-Accelerated SAMP8 Mice [0.03%]
甘油醛-1过表达导致的性别差异性的认知和代谢效益在衰老的小鼠模型中的研究
Alcir Luiz Dafre,Taketo Taguchi,Yelena Dayn et al.
Alcir Luiz Dafre et al.
As the size of the elderly population increases, the need for an improved understanding of what leads to the age-related decline in physiological function continues to grow. SAMP8 mice were selected for their accelerated aging phenotype. Th...
Patient-derived TXNIP-deficient primary cells exhibit NRF2 activation linked to upregulation of glyoxalase 1 (GLO1) [0.03%]
患者衍生的TXNIP缺陷型原代细胞表现出与糖基醛酶I(GLO1)上调相关的NRF2活化现象
Shayida Maimaiti,Markus Dagnell,Lucia Coppo et al.
Shayida Maimaiti et al.
Thioredoxin-interacting protein (TXNIP) plays a pivotal role in cellular redox regulation and has been implicated in various pathological conditions, including oxidative stress, inflammation and metabolic disorders including diabetes. In th...
Protocatechualdehyde attenuates oxidative stress in diabetic cataract via GLO1-mediated inhibition of AGE/RAGE glycosylation [0.03%]
原儿茶醛通过GLO1介导的AGE / RAGE糖基化抑制减轻糖尿病白内障的氧化应激
Xiao Cheng,Sixuan Zhao,Yucai Chen et al.
Xiao Cheng et al.
Background: Protocatechualdehyde (PCA), a phenolic compound derived from Salvia miltiorrhiza, exhibits anti-proliferative and antioxidant properties. However, its molecular mechanisms in reducing oxidative stress in diabe...
Paracrine Orchestration of Tumor Microenvironment Remodeling Induced by GLO1 Potentiates Lymph Node Metastasis in Breast Cancer [0.03%]
GLO1诱导的肿瘤微环境重编程促乳腺癌淋巴结转移的旁分泌网络构建及其机制研究
Jindong Xie,Wenjian Liu,Xinpei Deng et al.
Jindong Xie et al.
Breast cancer is the most prevalent form of malignant tumor that frequently metastasizes to axillary lymph nodes (LNs). Nonetheless, the precise mechanisms underlying alterations in the tumor microenvironment (TME) in LN metastasis in breas...
The implementation of reusable drapes and gowns in operating theatres: A mixed-methods analysis of data from 5230 peri-operative professionals in 134 countries [0.03%]
一次性手术布单和隔离 gown 的重复使用：基于 134 个国家 5230 名围术期医务人员混合研究方法的数据分析
Virginia Ledda,Aneel Bhangu,James Glasbey et al.
Virginia Ledda et al.
Background: Reuse of sterile textiles could potentially reduce the carbon footprint of operating theatres. The aim of this mixed-methods study is to gain a deeper understanding of the implementation of reusable drapes and...
Pharmacological and genetic manipulation of glyoxalase-1 (GLO1) does not alter locomotor responses or conditioned place preference induced by cocaine or oxycodone [0.03%]
药理学和遗传学上对于脱氧核糖核酸酶I（GLO1）的调控并不会改变可卡因或羟考酮引起的运动反应或者环境条件下的位置偏好反应
Elizabeth Alcantara,Michelle R Doyle,Clara A Ortez et al.
Elizabeth Alcantara et al.
Methylglyoxal (MG) is an endogenously produced non-enzymatic side product of glycolysis that acts as a partial agonist at GABAA receptors. MG is metabolized by the enzyme glyoxalase-1 (GLO1). Inhibition of GLO1 increases methylglyoxal level...
Extended Laminectomy in Chiari Malformation Treatment: A Systematic Review [0.03%]
小脑扁桃体下疝畸形治疗中扩大椎板切除术的系统评价
Guilherme L O Lima,Fábio B R Silva,Daniel F F Paiva
Guilherme L O Lima
Extended C2 laminectomy may expand the formation of the neocisterna magna in Chiari malformation (CM) surgery to improve cerebrospinal fluid (CSF) flow in the craniovertebral junction (CVJ). We aimed to clarify indications, outcomes, and co...
Phenotypic Variation and Pubertal Outcomes in Males and Females with 46,XY Partial Gonadal Dysgenesis [0.03%]
46,XY部分性性腺发育不全患者的表型变异及性征发展结局（英文）
Rieko Tadokoro-Cuccaro,Ieuan A Hughes,Martine Cools et al.
Rieko Tadokoro-Cuccaro et al.
Background: 46,XY gonadal dysgenesis is classified as complete (CGD) or partial (PGD) subtypes. The phenotype of PGD and the long-term outcome is not clearly defined. ...
Alterations in DNA Methylation, Proteomic, and Metabolomic Profiles in African Ancestry Populations with APOL1 Risk Alleles [0.03%]
带有APOL1风险等位基因的非洲血统人群的DNA甲基化、蛋白质组和代谢组特征变化
Xinruo Zhang,Ashley W Scadden,Amarnath Marthi et al.
Xinruo Zhang et al.
Background: The APOL1 high-risk haplotype has been associated with chronic kidney disease (CKD) and the deterioration of kidney function, particularly in populations with West African ancestry. However, the mechanisms by ...
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