Identification of DNA Repair-related Genes as Biomarkers Reflecting MSI, TMB, and TIL in Colorectal Cancer [0.03%]
识别DNA修复相关基因作为反映微卫星不稳定性、肿瘤突变负荷和肿瘤浸润淋巴细胞的生物标志物在结直肠癌中的作用
Junya Fukuda,Tomoya Sudo,Maako Kikuchi et al.
Junya Fukuda et al.
Background/aim: There are no established biomarkers for immune checkpoint inhibitors (ICI) in colorectal cancer (CRC) with microsatellite stability (MSS) or proficient mismatch repair (pMMR). Therefore, this study aimed t...
DNA repair biomarkers to guide usage of combined PARP inhibitors and chemotherapy: A meta-analysis and systematic review [0.03%]
用于联合使用PARP抑制剂和化疗的DNA修复生物标志物的meta分析和系统性综述
Zoe Phan,Caroline E Ford,C Elizabeth Caldon
Zoe Phan
Purpose: The addition of PARP inhibitors to chemotherapy has been assessed in > 80 clinical trials across multiple malignancies, on the premise that PARP inhibitors will increase chemotherapy effectiveness regardless of w...
Quantitative DNA Repair Biomarkers and Immune Profiling for Temozolomide and Olaparib in Metastatic Colorectal Cancer [0.03%]
DNA修复生物标志物和免疫分型在转移性结直肠癌中替莫唑胺和奥拉帕利的临床研究
Michael Cecchini,Janie Y Zhang,Wei Wei et al.
Michael Cecchini et al.
Purpose: O6-methylguanine DNA methyltransferase (MGMT)-silenced tumors reveal sensitivity to temozolomide (TMZ), which may be enhanced by PARP inhibitors. Approximately 40% of colorectal cancer has MGMT silencing and we a...
Expanded usage of the Challenge-Comet assay as a DNA repair biomarker in human populations: protocols for fresh and cryopreserved blood samples, and for different challenge agents [0.03%]
挑战-彗星试验作为人类群体DNA修复生物标志物的扩展应用：新鲜和冷冻保存血液样本以及不同挑战试剂的protocol
Vanessa Valdiglesias,María Sánchez-Flores,Natalia Fernández-Bertólez et al.
Vanessa Valdiglesias et al.
Deficiencies in DNA damage response and repair (DDRR) can cause serious pathological outcomes; therefore, having an ability to determine individual DDRR would enhance specificities in health risk assessment and in determining individual's r...
DNA Repair Biomarker for Lung Cancer Risk and its Correlation With Airway Cells Gene Expression [0.03%]
肺癌风险的DNA修复生物标志物及其与气道细胞基因表达的相关性
Tamar Paz-Elizur,Yael Leitner-Dagan,Kerstin B Meyer et al.
Tamar Paz-Elizur et al.
Background: Improving lung cancer risk assessment is required because current early-detection screening criteria miss most cases. We therefore examined the utility for lung cancer risk assessment of a DNA Repair score obt...
Biomarkers of DNA Repair and Related Pathways: Significance of Treatment in Triple-Negative Breast Cancer [0.03%]
三阴性乳腺癌治疗中DNA修复及相关的途径生物标志物的意义
Wenwen Guo,Li Lin,Xue He et al.
Wenwen Guo et al.
Triple-negative breast cancer (TNBC) is a complex heterogeneous disease that lacks the expressions of hormone receptors (HR) and human epidermal growth factor receptor 2 (HER2). Although TNBC make up less than 20% of breast cancer, it accou...
Alexis Vallard,Chloé Rancoule,Jean-Baptiste Guy et al.
Alexis Vallard et al.
The identification of DNA repair biomarkers is of paramount importance. Indeed, it is the first step in the process of modulating radiosensitivity and radioresistance. Unlike tools of detection and measurement of DNA damage, DNA repair biom...
Increased γ-H2AX and Rad51 DNA Repair Biomarker Expression in Human Cell Lines Resistant to the Chemotherapeutic Agents Nitrogen Mustard and Cisplatin [0.03%]
氮芥和顺铂抗性人细胞系中DNA修复生物标志物γ-H2AX和Rad51表达升高
Sheba Adam-Zahir,Piers N Plowman,Emma C Bourton et al.
Sheba Adam-Zahir et al.
Chemotherapeutic anticancer drugs mediate cytotoxicity by a number of mechanisms. However, alkylating agents which induce DNA interstrand crosslinks (ICL) are amongst the most effective anticancer agents and often form the mainstay of many ...
DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer [0.03%]
DNA修复生物标志物XPF和磷酸化MAPKAP激酶2与晚期头颈部肿瘤的临床结果相关性研究
Tanguy Y Seiwert,XiaoZhe Wang,Jana Heitmann et al.
Tanguy Y Seiwert et al.
Background: Induction chemotherapy is a common therapeutic option for patients with locoregionally-advanced head and neck cancer (HNC), but it remains unclear which patients will benefit. In this study, we searched for bi...
Andrew R Collins,Lynnette R Ferguson
Andrew R Collins
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