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Cancer research communications. 2023 Jun 28;3(6):1132-1139. doi: 10.1158/2767-9764.CRC-23-0045 Q23.32025

Quantitative DNA Repair Biomarkers and Immune Profiling for Temozolomide and Olaparib in Metastatic Colorectal Cancer

DNA修复生物标志物和免疫分型在转移性结直肠癌中替莫唑胺和奥拉帕利的临床研究 翻译改进

Michael Cecchini  1, Janie Y Zhang  2, Wei Wei  3, Jeffrey Sklar  4, Jill Lacy  1, Minghao Zhong  4, Yong Kong  3, Hongyu Zhao  3, Jassim DiPalermo  4, Lesley Devine  5, Stacey M Stein  1, Jeremy Kortmansky  1, Kimberly L Johung  6, Ranjit S Bindra  6, Patricia LoRusso  1, Kurt A Schalper  4

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作者单位

  • 1 Department of Internal Medicine (Medical Oncology), Yale University School of Medicine, New Haven, Connecticut.
  • 2 Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • 3 Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut.
  • 4 Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.
  • 5 Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut.
  • 6 Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut.

    • DOI: 10.1158/2767-9764.CRC-23-0045 PMID: 37387791

    摘要 Ai翻译

    Purpose: O6-methylguanine DNA methyltransferase (MGMT)-silenced tumors reveal sensitivity to temozolomide (TMZ), which may be enhanced by PARP inhibitors. Approximately 40% of colorectal cancer has MGMT silencing and we aimed to measure antitumoral and immunomodulatory effects from TMZ and olaparib in colorectal cancer. Experimental design: ... ...点击完成人机验证后继续浏览
    Copyright © Cancer research communications. 中文内容为AI机器翻译，仅供参考！

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    期刊名：Cancer research communications

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    ISSN：N/A

    e-ISSN：2767-9764

    IF/分区：3.3/Q2

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    Quantitative DNA Repair Biomarkers and Immune Profiling for Temozolomide and Olaparib in Metastatic Colorectal Cancer