First-in-human PET imaging and evaluation of melanin-targeted [18F]DMPY2 in malignant melanoma patients [0.03%]
恶性黑色素瘤患者中针对黑色素的正电子发射断层扫描成像以及[18F]DMPY2的首次人体评估研究
Yi Yang,Ming Zhou,Shuang Zhao et al.
Yi Yang et al.
Aim: Early diagnosis and accurate malignant melanoma (MM) staging are significant and decisive in clinical practice. [18F]DMPY2 is a promising PET tracer in vivo with high affinity and selectivity for melanin. The study aims to investigate ...
First-in-Humans PET Imaging of KRASG12C Mutation Status in Non-Small Cell Lung and Colorectal Cancer Patients Using [18F]PFPMD [0.03%]
用于非小细胞肺癌和结直肠癌患者的携带KRASG12C突变状态的[18F]PFPMD首次人体PET成像研究
Xiang Li,Jiajun Ye,Jingyi Wang et al.
Xiang Li et al.
Kirsten rat sarcoma (KRAS) mutations are an important marker for tumor-targeted therapy. In this study, we sought to develop a KRASG12C oncoprotein-targeted PET tracer and to evaluate its translational potential for noninvasive imaging of t...
First-in-Humans PET Imaging of Tissue Factor in Patients with Primary and Metastatic Cancers Using 18F-labeled Active-Site Inhibited Factor VII (18F-ASIS): Potential as Companion Diagnostic [0.03%]
使用18F标记的活性位点抑制性因子VII（18F-ASIS）对原发性和继发性癌症患者进行组织因子首次人体PET成像：作为伴随诊断的潜力
Mathias Loft,Camilla Christensen,Malene M Clausen et al.
Mathias Loft et al.
Tissue factor (TF) expression in cancers correlates with poor prognosis. Recently, the first TF-targeted therapy was approved by the U.S. Food and Drug Administration for cervical cancer. To unfold the potential of TF-targeted therapies, co...
First-in-Human PET Imaging and Estimated Radiation Dosimetry of l-[5-11C]-Glutamine in Patients with Metastatic Colorectal Cancer [0.03%]
l-[5-11C]谷氨酰胺在转移性结直肠癌患者中的首次人体PET成像和估算辐射剂量学
Allison S Cohen,Joe Grudzinski,Gary T Smith et al.
Allison S Cohen et al.
Altered metabolism is a hallmark of cancer. In addition to glucose, glutamine is an important nutrient for cellular growth and proliferation. Noninvasive imaging via PET may help facilitate precision treatment of cancer through patient sele...