Dietary Flaxseed Oil and Its Blended Oil Alleviate High-Fat Diet-Induced Obesity in Mice by Improving Lipid Metabolism and Regulating Gut Microbiota [0.03%]
亚麻籽油及其调和油通过改善脂质代谢和调节肠道菌群缓解小鼠高脂饮食诱导的肥胖症
Haizhen Li,Mingyue Shen,Xianxiang Chen et al.
Haizhen Li et al.
Obesity represents a chronic metabolic disorder feature by dysregulated glucose-lipid homeostasis. We investigated the effects of flaxseed oil (FO), rich in α-linolenic acid, and its blended oil (BO) on high-fat diet-induced obese mice. In...
Fermented ginseng powder enriched with rare ginsenosides ameliorates high-fat diet-induced obesity by modulating adipogenesis and inflammation [0.03%]
发酵低糖人参粉富含稀有人参皂苷通过调节脂肪生成和炎症改善高脂饮食诱导的肥胖症状
Xueyue Tai,Jiating Li,Jianwei Song et al.
Xueyue Tai et al.
Administration of high-dose fermented ginseng powder (2.385 mg/g) resulted in a reduction in body weight and an improvement in blood biochemical parameters in high-fat diet (HFD)-fed mice. Significant reductions in lipid droplet size were o...
Phosphodiesterase 5 Inhibitor Improves Insulin Sensitivity by Regulating Adipose Tissue Macrophage Polarization in Diet-Induced Obese Mice [0.03%]
磷酸二酯酶5抑制剂通过调节饮食诱导的肥胖小鼠脂肪组织巨噬细胞极化来改善胰岛素敏感性
Dan-Gyeong Song,Seongwon Pak,Dae-Chul Shin et al.
Dan-Gyeong Song et al.
Background: Obesity is a rapidly increasing global health issue, which is associated with glucose and insulin resistance. Phosphodiesterase type 5 (PDE5) inhibitors (PDE5i) are known for their ability to enhance blood flo...
Whole body and hematopoietic cell-specific deletion of G-protein coupled receptor 65 (GPR65) improves insulin sensitivity in diet-induced obese mice [0.03%]
全长身体和造血细胞特异性删除g蛋白偶联受体65(GPR65)可改善饮食诱导的肥胖小鼠的胰岛素敏感性
Yingjiang Zhou,EunJu Bae,Simon S Hoffman et al.
Yingjiang Zhou et al.
Chronic, low-grade inflammation is a key contributor to the etiology of obesity-induced insulin resistance, where pro-inflammatory macrophage polarization in obesity promotes the development of a deleterious inflammatory microenvironment. I...
Resveratrol Prevents Weight Gain, Counteracts Visceral Adipose Tissue Dysfunction, and Improves Hypothalamic Leptin Sensitivity in Diet-Induced Obese Rats [0.03%]
白藜芦醇可预防体重增加，改善饮食诱导的肥胖大鼠内脏脂肪组织功能障碍及下丘脑瘦素敏感性
Maria Ibars-Serra,Aïda Pascual-Serrano,Andrea Ardid-Ruiz et al.
Maria Ibars-Serra et al.
In obesity, increased adipocyte size is associated with metabolic complications, while elevated adipocyte numbers are considered a protective mechanism against metabolic disturbances. Adipose tissue dysfunction leads to decreased leptin sen...
The Chimeric Peptide (GEP44) Reduces Body Weight and Both Energy Intake and Energy Expenditure in Diet-Induced Obese Rats [0.03%]
嵌合肽(GEP44)通过减少摄食和产热以外的机制降低肥胖大鼠体重
Matvey Goldberg,James E Blevins,Tami Wolden-Hanson et al.
Matvey Goldberg et al.
We recently reported that a chimeric peptide (GEP44) targeting the glucagon-like peptide-1 receptor (GLP-1R) and neuropeptide Y1- and Y2- receptors decreased body weight (BW), energy intake, and core temperature in diet-induced obese (DIO) ...
The dual targeting effects of KD025 on casein kinase 2 and ROCK2 in a mouse model of diet-induced obesity [0.03%]
KD025对饮食诱导的肥胖小鼠模型中酪蛋白激酶2和ROCK2的双重靶向效应
Nhu Nguyen Quynh Tran,Hojung Choi,Bathiga Sactivel et al.
Nhu Nguyen Quynh Tran et al.
KD025(belumosudil), a selective ROCK2 inhibitor, exhibits unique anti-adipogenic activity through inhibition of casein kinase 2 (CK2). This study investigated the dual inhibitory effects of KD025 on metabolic in a diet-induced obese model. ...
Browning of inguinal white adipose tissue by the novel lignan (-)-secoisolariciresinol 4-O-methyl ether attenuates diet-induced obesity through mitochondrial and Peroxisomal activation [0.03%]
新型木脂素(-)-松脂素-4-O-甲基醚棕色化腹股沟白色脂肪组织并通过线粒体和过氧化物酶体激活来缓解饮食诱导的肥胖症
Wenjun Jiao,Woo Yong Park,Yong-Il Kim et al.
Wenjun Jiao et al.
Studies indicate that the induction and activation of brown and beige adipocytes, which can enhance energy expenditure, may be beneficial for managing obesity and its associated diseases. This study investigated whether a novel lignan (-)-s...
Brd9 antagonism induces beige adipocytes in white adipose tissues and protects against diet-induced obesity [0.03%]
Brd9拮抗作用可在白色脂肪组织中诱导出贝吉氏脂肪细胞并抵抗饮食引起的肥胖现象
Yang Liu,Amelia Yin,Kendall Seese et al.
Yang Liu et al.
Objective: Thermogenic beige adipocytes emerge in white adipose tissue (WAT) under certain physiological and pathological conditions, leading to increased energy expenditure, insulin sensitivity, and glucose tolerance. Th...
Oat β-glucan prevents high fat diet induced obesity by targeting ileal Farnesoid X receptor-fibroblast growth factor 15 signaling [0.03%]
燕麦β-葡聚糖通过作用于回肠法尼醇X受体-成纤维细胞生长因子15信号通路来预防高脂饮食诱导的肥胖症
Kai Huang,Chunyan Hong,Yuanyi Huang et al.
Kai Huang et al.
Oat β-glucan has demonstrated an anti-obesity effect against high fat diet. However, its precise regulatory mechanism remains unclear. The anti-obesity effect was related to the structural characteristics. In this study, different molecula...
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