Emu-miR-10a-5p in Echinococcus multilocularis-derived-extracellular vesicles alleviates airway inflammation in mice with allergic asthma by inhibiting macrophage M2a polarization through LIF-mediated JAK1-STAT3 signaling [0.03%]
鸸鹋emr-10a-5p通过干扰素介导的jak1-stat3信号抑制小鼠哮喘源性巨噬细胞m2a极化以减轻气道炎症
Yunzhuo Xin,Rou Wen,Dong Song et al.
Yunzhuo Xin et al.
Introduction: Parasites and parasite-derived extracellular vesicles (EVs) and microRNAs (miRNAs) can protect against inflammatory diseases, such as asthma. M2a macrophages facilitate the development of allergic asthma. mi...
Comparative Analysis of ICS Combined with LABA versus Addition of Omalizumab on Transcriptomic Expression Profiles in Patients with Allergic Asthma [0.03%]
ICS联合LABA与添加奥马珠单抗对过敏性哮喘患者转录组表达谱影响的比较分析
Ya-Ru Liang,Chuan-Hsin Chang,Shiang-Yu Huang et al.
Ya-Ru Liang et al.
Introduction: Asthma causes airway inflammation, leading to symptoms that impair patients' quality of life, making it a significant global public health issue. Inhaled corticosteroids (ICS) with long-acting beta-agonists ...
Association analysis of polymorphisms in IL-5 and IL-9, with Allergic Asthma disease in Al-Diwaniyah City [0.03%]
伊拉克迪瓦尼耶市IL-5和IL-9多态性与过敏性哮喘的关联分析
Mervat Kamel Kadhom,Rasha Muzahem Hatem,Khetam Ibrahim Mohammed
Mervat Kamel Kadhom
BackgroundThe purpose of this research is to examine whether or not there is a connection between polymorphisms in the IL-5 and IL-9 genes and the prevalence of allergic asthma in Iraqi patients.ObjectiveTo investigate the variants in the g...
BRL-50481 Ameliorates Lung Inflammation in a Murine Model of Ovalbumin-Induced Allergic Asthma with Co-Exposure to Lipopolysaccharide [0.03%]
巴夫霉素BRL-50481可减轻脂多糖联合作用于卵清蛋白致敏的小鼠模型中引起的哮喘肺部炎症作用
Oh Seong Kwon,Kyu-Taek Hwang,Won Seok Choi et al.
Oh Seong Kwon et al.
Asthma is an allergic inflammatory disease of the lungs characterized by eosinophilic inflammation, mucus hypersecretion, and airway hyperresponsiveness (AHR). Exposure to environmental endotoxins, such as lipopolysaccharide (LPS), can exac...
GLCCI1 ameliorates mitochondrial dysfunction in allergic asthma mice via DYRK1A/FAM117B-dependent NRF2 activation [0.03%]
GLCCI1通过DYRK1A/FAM117B依赖的NRF2激活缓解过敏性哮喘小鼠的线粒体功能障碍
Qiufen Xun,Qing Yang,Wei Wang et al.
Qiufen Xun et al.
Allergic asthma significantly impacts individuals' quality of life and work. This study aimed to investigate the specific mechanisms by which GLCCI1 regulated mitochondrial dysfunction in allergic asthma mice. In an ovalbumin (OVA)-induced ...
Modulating Dendritic Cell function in Allergic Asthma with Toxoplasma gondii serine-protease inhibitor 1 [0.03%]
用弓形虫丝氨酸蛋白酶抑制因子1调节过敏性哮喘小胶质细胞的功能
Joel Katan Piñeiro,Ariadna Soledad Soto,Ana Farias et al.
Joel Katan Piñeiro et al.
Tolerogenic adjuvants can enhance allergy vaccine efficacy. We previously showed that intranasal administration of recombinant Toxoplasma gondii serine protease inhibitor 1 (rTgPI-1) with ovalbumin alleviates asthma symptoms in mice. This s...
Recombinant BCG Expressing IL-12 as A Novel Immunomodulatory Strategy for Allergic Asthma: Opportunities and Challenges [0.03%]
表达IL-12的重组卡介苗作为过敏性哮喘免疫调节策略的新方法：机遇与挑战
Romina Campos-Povea,Enrique González-Madrid,Tays Troncoso-Bravo et al.
Romina Campos-Povea et al.
Allergic asthma is a chronic respiratory disorder driven by a T helper type 2 (Th2)-mediated immune response that involves eosinophils and mast cell recruitment to affected tissues, eliciting inflammatory cytokines and IgE production. Typic...
MOTS-c attenuates airway barrier dysfunction in allergic asthma by inhibiting epithelial apoptosis via Nrf2 pathway [0.03%]
MOTS-c通过Nrf2途径抑制上皮细胞凋亡来缓解过敏性哮喘气道屏障功能障碍
Wenlong Zhang,Shengpeng Li,Yanli Zhang et al.
Wenlong Zhang et al.
Background: Allergic asthma (AA), a severe chronic respiratory disease of chronic airway inflammation, is characterized by bronchial epithelial barrier dysfunction. The MOTS-c/nuclear factor erythroid 2-related factor 2 (...
BHLHE40 contributes to allergic asthma progression in mice through NRTN downregulation in macrophages [0.03%]
BHLHE40通过下调巨噬细胞中的NRTN促进小鼠过敏性哮喘的发展
Bing Dai,Li Chen,Xiaowen Li et al.
Bing Dai et al.
Alternatively activated M2-like macrophages have a profound impact on asthma pathogenesis. Basic Helix-Loop-Helix Family Member E40 (BHLHE40), a dimeric transcriptional factor, plays a key regulation in macrophage functions. Here we show th...
Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma [0.03%]
健康状况和过敏性哮喘下支气管肺泡及呼吸道黏膜T细胞的不同表型和配体 repertoire
Rod A Rahimi,Neal P Smith,Amandine Selle et al.
Rod A Rahimi et al.
Background: T cells play a central role in host protection against respiratory pathogens, but a maladaptive T cell response can lead to pulmonary diseases. Defining the biology of protective versus pathogenic T cell respo...
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