Reference Vector-guided Evolutionary Algorithm for cluster analysis of single-cell transcriptomes [0.03%]
参考向量引导进化算法在单细胞转录组聚类分析中的应用研究
Fernando M Rodríguez-Bejarano,Miguel A Vega-Rodríguez,Sergio Santander-Jiménez
Fernando M Rodríguez-Bejarano
Background and objective: Single-cell RNA-sequencing (scRNA-seq) has revolutionized transcriptomic studies by providing detailed insights into gene expression profiles at the single-cell level. This technology allows rese...
The influence of chronic cadmium exposure on the activity of adult Pelophylax nigromaculatus revealed by brain transcriptomics and metabolomics [0.03%]
慢性镉暴露对黑斑蛙脑功能影响的转录组和代谢组学研究
Yuhao Zhang,Minyi Huang,Renyan Duan et al.
Yuhao Zhang et al.
Cadmium (Cd), a common environmental pollutant, has potentially negative effects on the behavior of aquatic animals. This study investigated the effects of exposure to Cd (0 mg/L, 1 mg/L and 10 mg/L) on movement behavior, brain metabolites,...
Integrated transcriptomic, metabolomic, and lipidomic analyses reveal a unique lipid profile of regulatory T cells upon activation [0.03%]
整合转录组、代谢组和脂质组分析揭示激活后调节性T细胞独特的脂质特征
Yohei Sato,Misa Yura,Alana Chandler et al.
Yohei Sato et al.
Regulatory T cells (Tregs) exhibit stable FOXP3 expression and regulate the immune response through suppressive activity. Their unique metabolic properties include increased glycolysis and oxidative phosphorylation. We combined transcriptom...
SOAR elucidates biological insights and empowers drug discovery through spatial transcriptomics [0.03%]
基于空间转录组的肿瘤免疫微环境解析及药物靶点发现
Yiming Li,Yanyi Ding,Saya Dennis et al.
Yiming Li et al.
Spatial transcriptomics enables multiplex profiling of gene cellular expression and location within the tissue context. Although large volumes of spatial transcriptomics data have been generated, the lack of systematic curation and analysis...
Identification and Mapping of Human Lymph Node Stromal Cell Subsets by Combining Single-Cell RNA Sequencing with Spatial Transcriptomics [0.03%]
结合单细胞RNA测序和空间转录组学鉴定和绘制人类淋巴结基质细胞亚群
Cristoforo Grasso,Janna E G Roet,Catarina Gago de Graça et al.
Cristoforo Grasso et al.
Lymph node stromal cells (LNSCs) have a crucial immunomodulatory function, but their heterogeneity in humans is incompletely understood. Here, we report the single-cell RNA sequencing (scRNA-seq) of 9267 LNSCs isolated from a human lymph no...
Periodontitis Exacerbates Cognitive Impairment via Endothelial Inflammation: Insights from Single-Nucleus Transcriptomics [0.03%]
牙周炎通过内皮炎症加重认知障碍：单核转录组学的见解
Zong Shan Shen,Ji Chen Yang,Chuan Jiang Zhao et al.
Zong Shan Shen et al.
Objective: To explore the underlying mechanisms of the association between periodontitis and cognitive impairment. Methods: Single-nucl...
Filtering for Highly Variable Genes and High-Quality Spots Improves Phylogenetic Analysis of Cancer Spatial Transcriptomics Visium Data [0.03%]
过滤高变基因和高质量spots可改善癌症空间转录组学Visium数据的系统发育分析
Alexandra Sasha Gavryushkina,Holly R Pinkney,Sarah D Diermeier et al.
Alexandra Sasha Gavryushkina et al.
Phylogenetic relationship of cells within tumors can help us to understand how cancer develops in space and time and identify driver mutations and other evolutionary events that enable cancer growth and spread. Numerous studies have reconst...
Integration of single-cell and spatial transcriptomics by SEU-TCA reveals the spatial origin of early cardiac progenitors [0.03%]
通过SEU-TCA整合单细胞和空间转录组学揭示早期心脏祖细胞的空间起源
Jingjing He,Yi Yang,Rui Jiang et al.
Jingjing He et al.
Obtaining single-cell spatial information remains a challenge in spatial transcriptomics. Here we develop SEU-TCA, a method that leverages transfer component analysis to improve single-cell spatial mapping accuracy. Application to multiple ...
Exploring individual differences in fear extinction in male and female mice: insights from HPA axis, microbiota, and transcriptomics [0.03%]
从HPA轴、微生物群和转录组学探讨雄性和雌性小鼠恐惧消退的个体差异：洞察
Marc Ten-Blanco,María Ponce-Renilla,Inmaculada Pereda-Pérez et al.
Marc Ten-Blanco et al.
Exposure to traumatic life events may compromise physical and mental health of specific subjects. While some individuals extinguish fear appropriately, others exhibit an inefficient and persistent fear response, with remarkable differences ...
Spatial Transcriptomics Unveils the Blueprint of Mammalian Lung Development [0.03%]
空间转录组学揭示哺乳动物肺发育蓝图
Mingyue Chen 陈明月,Junjie Lv 吕俊杰,Qiao Zhang 张乔 et al.
Mingyue Chen 陈明月 et al.
Mammalian lung development is a complex, highly orchestrated process involving the precise coordination of diverse cell types. Despite significant advances, the spatial gene expression patterns and regulatory mechanisms within the developme...
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