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Alexandra Negatsch,Harald Granzow,Christina Maresch et al. Alexandra Negatsch et al.
After primary replication at the site of entry into the host, alphaherpesviruses infect and establish latency in neurons. To this end, they are transported within axons retrograde from the periphery to the cell body for replication and in a...
Eva Herker,Charles Harris,Céline Hernandez et al. Eva Herker et al.
Hepatitis C virus (HCV) infection is closely tied to the lipid metabolism of liver cells. Here we identify the triglyceride-synthesizing enzyme diacylglycerol acyltransferase-1 (DGAT1) as a key host factor for HCV infection. DGAT1 interacts...
Manli Wang,Era Tuladhar,Shu Shen et al. Manli Wang et al.
The majority of double-stranded DNA (dsDNA) viruses infecting eukaryotic organisms use host- or virus-expressed histones or protamine-like proteins to condense their genomes. In contrast, members of the Baculoviridae family use a protamine-...
Jeremy S Rossman,Xianghong Jing,George P Leser et al. Jeremy S Rossman et al.
Influenza A virus buds from cells as spherical (approximately 100-nm diameter) and filamentous (approximately 100 nm x 2 to 20 microm) virions. Previous work has determined that the matrix protein (M1) confers the ability of the virus to fo...
Jonas Klingström,Sara Akerström,Jonas Hardestam et al. Jonas Klingström et al.
Reactive nitrogen intermediates (RNI), like nitric oxide (NO) and peroxynitrite, have antiviral effects against certain viruses. Hantaviruses, like other members of the Bunyaviridae family, have previously not been shown to be sensitive to ...
Ya-Xiong Feng,Tong Li,Stephen Campbell et al. Ya-Xiong Feng et al.
Recombinant human immunodeficiency virus type 1 (HIV-1) Gag protein can assemble into virus-like particles (VLPs) in suitable buffer conditions with nucleic acid. We have explored the role of nucleic acid in this assembly process. HIV-1 nuc...
Editte Gharakhanian,Clare L Fasching,Salvatore J Orlando et al. Editte Gharakhanian et al.
Structural studies have implicated Cys(9), Cys(104) and Cys(207) of simian virus 40 (SV40) Vp1 in disulfide bond formation. Recently, we have shown the three cysteines to be essential for disulfide linkage of Vp1 complexes in vitro. Here, t...
C Probst,M Jecht,V Gauss-Müller C Probst
Proteolytic processing of the picornaviral polyprotein mediated by the differential action of virus-encoded proteinase(s) is pivotal to both RNA genome replication and capsid formation. Possibly to enlarge the array of viral proteins, picor...
N Fischer,M Heinkelein,D Lindemann et al. N Fischer et al.
Subgenomic expression plasmids for the so-called human foamy virus (HFV) structural gag, gag/pol, and env genes were constructed and used to analyze foamy virus particle formation by electron microscopy. Expression of an R-U5-gag-pol constr...
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