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Nature medicine. 2010 Nov;16(11):1295-8. doi: 10.1038/nm.2238 Q150.02025

Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1

DGAT1酶在丙型肝炎病毒粒子形成过程中的作用不可或缺 翻译改进

Eva Herker  1, Charles Harris, Céline Hernandez, Arnaud Carpentier, Katrin Kaehlcke, Arielle R Rosenberg, Robert V Farese Jr, Melanie Ott

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  • 1 Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA.
  • DOI: 10.1038/nm.2238 PMID: 20935628

    摘要 Ai翻译

    Hepatitis C virus (HCV) infection is closely tied to the lipid metabolism of liver cells. Here we identify the triglyceride-synthesizing enzyme diacylglycerol acyltransferase-1 (DGAT1) as a key host factor for HCV infection. DGAT1 interacts with the viral nucleocapsid core and is required for the trafficking of core to lipid droplets. Inhibition of DGAT1 activity or RNAi-mediated knockdown of DGAT1 severely impairs infectious virion production, implicating... ...点击完成人机验证后继续浏览
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    期刊名:Nature medicine

    缩写:NAT MED

    ISSN:1078-8956

    e-ISSN:1546-170X

    IF/分区:50.0/Q1

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