SPHK2 inhibition alleviates chronic intermittent hypoxia-induced inflammation in adipose tissue by decreasing endoplasmic reticulum stress [0.03%]
SPHK2抑制通过降低内质网应激缓解慢性间歇性低氧诱导的脂肪组织炎症
Longyi Ran,Chang Wei,Xinyu Wang et al.
Longyi Ran et al.
Obstructive Sleep Apnea (OSA), characterized by chronic intermittent hypoxia (CIH), is a prevalent disorder that significantly elevates the risk of cardiovascular and metabolic complications. Lipid metabolism disturbances, a common comorbid...
Contrasting effects of acute versus chronic intermittent hypoxia on leptin secretion in differentiated human adipocytes - Implications for sleep apnea [0.03%]
急性间歇性低氧与慢性间歇性低氧对分化的人体脂肪细胞的影响对比-睡眠呼吸暂停的含义
Kiran R Somers,Christiane Becari,Katarzyna Polonis et al.
Kiran R Somers et al.
Obstructive sleep apnea (OSA) is a common sleep disorder associated with repetitive episodes of nocturnal intermittent hypoxia (IH), obesity and elevated leptin. Newly diagnosed OSA patients have a history of significant recent weight gain....
Chronic Intermittent Hypoxia and Ovariectomy Exert Independent and Region-specific Effects on ΔFosB Expression and Increase Blood Pressure in Female Rats [0.03%]
慢性间歇性低氧和卵巢切除独立并区域特异性地影响雌鼠ΔFosB表达及血压升高效应
Cephas B Appiah,Joel T Little,George E Farmer et al.
Cephas B Appiah et al.
Chronic intermittent hypoxia (CIH), a preclinical model of hypoxemia associated with sleep apnea, causes hypertension associated with increased sympathetic activity linked to arterial chemoreflex and renin-angiotensin system activation. In ...
Metformin protects the heart against chronic intermittent hypoxia through AMPK-dependent phosphorylation of HIF-1α [0.03%]
二甲双胍通过AMPK依赖的HIF-1α磷酸化作用保护心肌免受慢性间歇低氧损伤的影响
Sophie Moulin,Britanny Blachot-Minassian,Anita Kneppers et al.
Sophie Moulin et al.
Chronic intermittent hypoxia (IH), a major feature of obstructive sleep apnea syndrome (OSA), is associated with greater severity of myocardial infarction. In this study, we performed RNA sequencing of cardiac samples from mice exposed to I...
Chronic intermittent hypoxia affects the expression of IRS - 2/p - Akt/GSK - 3 in the liver of SD rats and its impact on glucose metabolism [0.03%]
慢性间歇性低氧对SD大鼠肝脏IRS-2/p-Akt/GSK-3表达的影响及其糖代谢研究
Hong Wang,Tiantian Guo
Hong Wang
Background: Epidemiological studies indicate a strong association between OSA and type 2 diabetes. Currently, the insulin signal transduction pathway and its associated effector proteins have emerged as a focal point in t...
Chronic intermittent hypoxia exposure induces a unique microglial transcriptome in 5XFAD mice [0.03%]
慢性间歇性低氧暴露会在5XFAD小鼠中诱导独特的微胶质细胞转录组
Kaitlyn M Marino,Andrea C Ewald,Jaidynne N Lash et al.
Kaitlyn M Marino et al.
Clinical observations suggest that obstructive sleep apnea (OSA) and Alzheimer's disease (AD) pathology may be linked; however, causal mechanisms and relationships are unclear. To investigate the potential interaction between amyloidosis an...
Chronic Intermittent Hypoxia-Induced Neural Injury: Pathophysiology, Neurodegenerative Implications, and Therapeutic Insights [0.03%]
慢性间歇性缺氧诱导的神经损伤：病理生理学、神经退行性影响和治疗见解
Nan-Nan Jia,Meng-Fan Yao,Chun-Xue Zhu et al.
Nan-Nan Jia et al.
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a sleep-related respiratory disorder that poses a global threat to human health. Chronic intermittent hypoxia (CIH) is its main pathological feature. With the advancements in medical rese...
Biotransformation of ketamine in terminal in vivo experiments under chronic intermittent hypoxia conditions and the role of AhR [0.03%]
慢性间歇性缺氧条件下氯胺酮体内终末生物转化及芳烃受体的作用机制研究
António B Pimpão,Luísa Teixeira-Santos,Nuno R Coelho et al.
António B Pimpão et al.
We were pioneers in describing aryl hydrocarbon receptor (AhR) activation by chronic intermittent hypoxia (CIH) in a rat pre-clinical model. This model mimics hypertension (HTN) secondary to obstructive sleep apnea, enabling longitudinal in...
Chronic intermittent hypoxia alleviates alcohol-related liver injury via downregulation of hepatic hypoxia-inducible factor-2α [0.03%]
慢性间歇性低氧通过下调肝脏缺氧诱导因子-2α来缓解酒精相关肝损伤
Yunling Chen,Dongyuan Zhang,Yunxiao Wu et al.
Yunling Chen et al.
Background: Alcohol-related liver disease (ALD) is one of the leading causes of alcohol-related morbidity and mortality worldwide. Unfortunately, limited therapeutic options are currently available, due to the complex ris...
A comprehensive analysis of microRNA alteration in an ApoE(-/-) mice model of white adipose tissue injury induced by chronic intermittent hypoxia [0.03%]
慢性间歇性低氧诱导的载脂蛋白E基因缺失型小鼠白色脂肪组织损伤模型中的微小核糖核酸改变的全面分析
Jinjie Zhang,Yaopeng Guo,Meilin Ji et al.
Jinjie Zhang et al.
Background: MicroRNAs (miRNAs) represent a class of noncoding small RNAs and are implicated in many diseases. However, the role of miRNA in obstructive sleep apnea (OSA)-induced white adipose tissue (WAT) dysfunction rema...
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