Current state of epigenetics in giant cell arteritis: Focus on microRNA dysregulation [0.03%]
巨细胞动脉炎表观遗传学的当前状态：以微小核糖核酸失调为重点的研究
Luka Bolha,Alojzija Hočevar,Vesna Jurčić
Luka Bolha
Giant cell arteritis (GCA) is a primary systemic vasculitis affecting the elderly, characterized by a granulomatous vessel wall inflammation of large- and medium-sized arteries. The immunopathology of GCA is complex, involving both the inna...
Mesenchymal stromal cell transplantation ameliorates fibrosis and microRNA dysregulation in skeletal muscle ischemia [0.03%]
间充质基质细胞移植改善骨骼肌缺血的纤维化和microRNA失调现象
Clara Sanz-Nogués,Alan J Keane,Michael Creane et al.
Clara Sanz-Nogués et al.
Peripheral arterial disease (PAD) is associated with lower-extremity muscle wasting. Hallmark features of PAD-associated skeletal muscle pathology include loss of skeletal muscle mass, reduced strength and physical performance, increased in...
Novel C. elegans models of Lewy body disease reveal pathological protein interactions and widespread miRNA dysregulation [0.03%]
新颖的秀丽隐杆线虫路易体疾病模型揭示了病理蛋白相互作用和广泛微小rna失调
Rongzhen Li,Xiaobing Huang,Linjing Shen et al.
Rongzhen Li et al.
Lewy body diseases (LBD) comprise a group of complex neurodegenerative conditions originating from accumulation of misfolded alpha-synuclein (α-syn) in the form of Lewy bodies. LBD pathologies are characterized by α-syn deposition in asso...
MicroRNA dysregulation in myelodysplastic syndromes: implications for diagnosis, prognosis, and therapeutic response [0.03%]
微小核糖核酸在骨髓增生异常综合征中失调的诊断、预后和治疗反应的含义
Ilina Dimitrova Micheva,Svilena Angelova Atanasova
Ilina Dimitrova Micheva
Myelodysplastic syndromes (MDS) are a group of malignant clonal hematological disorders with heterogeneous clinical course and risk of transformation to acute myeloid leukemia. Genetic and epigenetic dysregulation, including alterations in ...
MicroRNA dysregulation and its impact on apoptosis-related signaling pathways in myelodysplastic syndrome [0.03%]
微小核糖核酸的失调及其对骨髓增生异常综合征中与细胞凋亡相关信号通路的影响研究
Neda Hedayati,Mobina Safaei Naeini,Mohammad Mahdi Ale Sahebfosoul et al.
Neda Hedayati et al.
Myelodysplastic syndrome (MDS) holds a unique position among blood cancers, encompassing a spectrum of blood-related disorders marked by impaired maturation of blood cell precursors, bone marrow abnormalities, genetic instability, and a hig...
Hui Yu,Limin Jiang,Chung-I Li et al.
Hui Yu et al.
Motivation: As an important player in transcriptome regulation, microRNAs may effectively diffuse somatic mutation impacts to broad cellular processes and ultimately manifest disease and dictate prognosis. Previous studie...
MiRNA dysregulation underlying common pathways in type 2 diabetes and cancer development: an Italian Association of Medical Oncology (AIOM)/Italian Association of Medical Diabetologists (AMD)/Italian Society of Diabetology (SID)/Italian Society of Endocrinology (SIE)/Italian Society of Pharmacology (SIF) multidisciplinary critical view [0.03%]
二型糖尿病与癌症发病过程中的共同途径：微小核糖核酸失调：意大利肿瘤学协会/意大利医学糖尿病学会/意大利糖尿病学会/意大利内分泌学会/意大利药理学会多学科观点
A Natalicchio,M Montagnani,M Gallo et al.
A Natalicchio et al.
Increasing evidence suggests that patients with diabetes, particularly type 2 diabetes (T2D), are characterized by an increased risk of developing different types of cancer, so cancer could be proposed as a new T2D-related complication. On ...
MicroRNA dysregulation in the heart and lung of infants with bronchopulmonary dysplasia [0.03%]
支气管肺发育不良婴儿心脏和肺的微小核糖核酸失调
Sara Koussa,Alan Dombkowski,Daniela Cukovic et al.
Sara Koussa et al.
BACKGROUND AND OBJECTIVES: Bronchopulmonary dysplasia (BPD) is a serious complication of preterm birth, resulting in significant morbidity and mortality. Recent studies have suggested that microRNA (miRNA) dysregulation is involved in the p...
miRNA Dysregulation in Cardiovascular Diseases: Current Opinion and Future Perspectives [0.03%]
心血管疾病中的微小核糖核酸功能失调：现状与未来展望
Francesco Sessa,Monica Salerno,Massimiliano Esposito et al.
Francesco Sessa et al.
MicroRNAs (miRNAs), small noncoding RNAs, are post-transcriptional gene regulators that can promote the degradation or decay of coding mRNAs, regulating protein synthesis. Many experimental studies have contributed to clarifying the functio...
Analysis of common genetic variation across targets of microRNAs dysregulated both in ASD and epilepsy reveals negative correlation [0.03%]
自闭症和癫痫共有的失调靶基因分析发现负相关性
Carol Stella,Covadonga M Díaz-Caneja,Maria Jose Penzol et al.
Carol Stella et al.
Genetic overlap involving rare disrupting mutations may contribute to high comorbidity rates between autism spectrum disorders and epilepsy. Despite their polygenic nature, genome-wide association studies have not reported a significant con...
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