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Frontiers in genetics. 2023 Mar 9:14:1072563. doi: 10.3389/fgene.2023.1072563 Q22.82025

Analysis of common genetic variation across targets of microRNAs dysregulated both in ASD and epilepsy reveals negative correlation

自闭症和癫痫共有的失调靶基因分析发现负相关性 翻译改进

Carol Stella  1  2  3, Covadonga M Díaz-Caneja  1  2  3  4, Maria Jose Penzol  1  2  3, Alicia García-Alcón  1  2  3, Andrea Solís  1  2  3, Álvaro Andreu-Bernabeu  1  2  3, Xaquín Gurriarán  1  2  3, Celso Arango  1  2  3  4, Mara Parellada  1  2  3  4, Javier González-Peñas  1  2  3

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作者单位

  • 1 Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
  • 2 Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
  • 3 CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Instituto de Salud Carlos III, Madrid, Spain.
  • 4 School of Medicine, Universidad Complutense, Madrid, Spain.

    • DOI: 10.3389/fgene.2023.1072563 PMID: 36968597

    摘要 Ai翻译

    Genetic overlap involving rare disrupting mutations may contribute to high comorbidity rates between autism spectrum disorders and epilepsy. Despite their polygenic nature, genome-wide association studies have not reported a significant contribution of common genetic variation to comorbidity between both conditions. Analysis of common genetic variation affecting specific shared pathways such as miRNA dysregulation could help to elucidate the polygenic mech... ...点击完成人机验证后继续浏览
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    期刊名：Frontiers in genetics

    缩写：FRONT GENET

    ISSN：N/A

    e-ISSN：1664-8021

    IF/分区：2.8/Q2

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    Analysis of common genetic variation across targets of microRNAs dysregulated both in ASD and epilepsy reveals negative correlation